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- W2110853268 abstract "ABSTRACT To identify cell proteins regulated by the Epstein-Barr virus (EBV) transcription factor EBNA-2, we analyzed a cell line with conditional EBNA-2 activity by using microarray expression profiling. This led to the identification of two novel target genes induced by EBNA-2. The first of these, interleukin-16, is an immunomodulatory cytokine involved in the regulation of CD4 T cells. The second, AML-2, is a member of the Runt domain family of transcription factors. Quiescent B cells initially expressed AML-1 but, 48 h after virus infection, the levels of AML-1 decreased dramatically, whereas the amount of AML-2 protein increased. Analysis of a panel of B-cell lines indicated that AML-2 expression is normally predominant in EBV latency III, whereas AML-1 is associated with EBV latency I or EBV-negative cells. The AML genes are the first example of cell transcription factors whose expression correlates with the latency I/III phenotype." @default.
- W2110853268 created "2016-06-24" @default.
- W2110853268 creator A5013715394 @default.
- W2110853268 creator A5030484951 @default.
- W2110853268 creator A5050147363 @default.
- W2110853268 creator A5084857690 @default.
- W2110853268 date "2002-05-15" @default.
- W2110853268 modified "2023-09-24" @default.
- W2110853268 title "Expression of Transcription Factor AML-2 (RUNX3, CBFα-3) Is Induced by Epstein-Barr Virus EBNA-2 and Correlates with the B-Cell Activation Phenotype" @default.
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- W2110853268 doi "https://doi.org/10.1128/jvi.76.10.4919-4927.2002" @default.
- W2110853268 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/136164" @default.
- W2110853268 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11967309" @default.
- W2110853268 hasPublicationYear "2002" @default.
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