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• W2110878879 abstract "Our genome-wide association study of celiac disease previously identified risk variants in the IL2–IL21 region. To identify additional risk variants, we genotyped 1,020 of the most strongly associated non-HLA markers in an additional 1,643 cases and 3,406 controls. Through joint analysis including the genome-wide association study data (767 cases, 1,422 controls), we identified seven previously unknown risk regions (P < 5 × 10−7). Six regions harbor genes controlling immune responses, including CCR3, IL12A, IL18RAP, RGS1, SH2B3 (nsSNP rs3184504) and TAGAP. Whole-blood IL18RAP mRNA expression correlated with IL18RAP genotype. Type 1 diabetes and celiac disease share HLA-DQ, IL2–IL21, CCR3 and SH2B3 risk regions. Thus, this extensive genome-wide association follow-up study has identified additional celiac disease risk variants in relevant biological pathways." @default.
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• W2110878879 date "2008-03-02" @default.
• W2110878879 modified "2023-10-16" @default.
• W2110878879 title "Newly identified genetic risk variants for celiac disease related to the immune response" @default.
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• W2110878879 doi "https://doi.org/10.1038/ng.102" @default.
• W2110878879 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2673512" @default.
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