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- W2110885280 abstract "Abstract Whereas cytokine production in αβ T cells is rapidly regulated by exposure to peptide Ag, the mechanisms regulating cytokine production by γδ T cells are unknown. In this study, we demonstrate that human Vγ2Vδ2 T cells produce IFN-γ and TNF-α as early as 2 h after Ag exposure, and that they produce these cytokines in a dose- and time- dependent manner in response to stimulation with a live bacterial product, iso-butylamine (IBA), but not to dead bacteria or LPS. γδ T cells began, ceased, and then resumed IFN-γ and TNF-α generation in an on/off/on cycling pattern, both in vitro and in vivo, depending on the presence or absence of IBA. IFN-γ and TNF-α, whose optimum production was dependent on IBA-stimulated γδ T cells, were critical for monocyte-mediated killing of Escherichia coli. By limiting cytokine production to periods of direct contact with live bacteria, γδ T cells focus their resources at the site of infection, while limiting systemic immunopathology. Thus, human γδ T cells may mediate innate resistance to extracellular bacteria via tightly regulated cytokine production without necessarily expanding in number." @default.
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- W2110885280 date "2001-12-01" @default.
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- W2110885280 title "Human Vγ2Vδ2 T Cells Produce IFN-γ and TNF-α with an On/Off/On Cycling Pattern in Response to Live Bacterial Products" @default.
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- W2110885280 doi "https://doi.org/10.4049/jimmunol.167.11.6195" @default.
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