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- W2110885327 abstract "Hypertension is one of the most common age-related chronic disorders, and by predisposing individuals for heart failure, stroke, and kidney disease, it is a major source of morbidity and mortality. Its etiology remains enigmatic despite intense research efforts over many decades. By use of empirically well-constrained computer models describing the coupled function of the baroreceptor reflex and mechanics of the circulatory system, we demonstrate quantitatively that arterial stiffening seems sufficient to explain age-related emergence of hypertension. Specifically, the empirically observed chronic changes in pulse pressure with age and the impaired capacity of hypertensive individuals to regulate short-term changes in blood pressure arise as emergent properties of the integrated system. The results are consistent with available experimental data from chemical and surgical manipulation of the cardio-vascular system. In contrast to widely held opinions, the results suggest that primary hypertension can be attributed to a mechanogenic etiology without challenging current conceptions of renal and sympathetic nervous system function." @default.
- W2110885327 created "2016-06-24" @default.
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- W2110885327 date "2014-05-22" @default.
- W2110885327 modified "2023-10-16" @default.
- W2110885327 title "Arterial Stiffening Provides Sufficient Explanation for Primary Hypertension" @default.
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- W2110885327 doi "https://doi.org/10.1371/journal.pcbi.1003634" @default.
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