FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2110885783> ?p ?o ?g. }

• W2110885783 endingPage "2723" @default.
• W2110885783 startingPage "2713" @default.
• W2110885783 abstract "Animal studies have shown that noxious inputs onto γ‐motoneurons can cause an increase in the activity of muscle spindles, and it has been proposed that this causes a fusimotor‐driven increase in muscle stiffness that is believed to underlie many chronic pain syndromes. To test whether experimental pain also acts on the fusimotor system in humans, unitary recordings were made from 19 spindle afferents (12 Ia, 7 II) located in the ankle and toe extensors or peronei muscles of awake human subjects. Muscle pain was induced by bolus intramuscular injection of 0.5 ml 5% hypertonic saline into tibialis anterior (TA); skin pain was induced by 0.2 ml injection into the overlying skin. Changes in fusimotor drive to the muscle spindles were inferred from changes in the mean discharge frequency and discharge variability of spindle endings in relaxed muscle. During muscle pain no afferents increased their discharge activity: seven afferents (5 Ia, 2 II) showed a decrease and six (4 Ia, 2 II) afferents were not affected. During skin pain of 13 afferents discharge rate increased in one (Ia) and decreased in two (1 Ia, 1 II). On average, the overall discharge rate decreased during muscle pain by 6.1% ( P < 0.05; Wilcoxon), but remained essentially the same during skin pain. There was no detectable correlation between subjective pain level and the small change in discharge rate of muscle spindles. Irrespective of the type of pain, discharge variability parameters were not influenced ( P > 0.05; Wilcoxon). We conclude that, contrary to the ‘vicious cycle’ hypothesis, acute activation of muscle or skin nociceptors does not cause a reflex increase in fusimotor drive in humans. Rather, our results are more aligned with the pain adaptation model, based on clinical studies predicting pain‐induced reductions of agonist muscle activity." @default.
• W2110885783 created "2016-06-24" @default.
• W2110885783 creator A5071451071 @default.
• W2110885783 creator A5076911397 @default.
• W2110885783 creator A5084631284 @default.
• W2110885783 date "2008-06-01" @default.
• W2110885783 modified "2023-10-14" @default.
• W2110885783 title "The effects of experimental muscle and skin pain on the static stretch sensitivity of human muscle spindles in relaxed leg muscles" @default.
• W2110885783 cites W1833708893 @default.
• W2110885783 cites W1928560244 @default.
• W2110885783 cites W1967546685 @default.
• W2110885783 cites W1971681527 @default.
• W2110885783 cites W1974564893 @default.
• W2110885783 cites W1980135255 @default.
• W2110885783 cites W1981336856 @default.
• W2110885783 cites W1982888771 @default.
• W2110885783 cites W1988802189 @default.
• W2110885783 cites W1991636357 @default.
• W2110885783 cites W1992744984 @default.
• W2110885783 cites W1994916645 @default.
• W2110885783 cites W2001927305 @default.
• W2110885783 cites W2004337831 @default.
• W2110885783 cites W2005527009 @default.
• W2110885783 cites W2009549712 @default.
• W2110885783 cites W2010501057 @default.
• W2110885783 cites W2036942092 @default.
• W2110885783 cites W2038337173 @default.
• W2110885783 cites W2039043268 @default.
• W2110885783 cites W2039597758 @default.
• W2110885783 cites W2045610583 @default.
• W2110885783 cites W2046958837 @default.
• W2110885783 cites W2047281269 @default.
• W2110885783 cites W2056517236 @default.
• W2110885783 cites W2062460763 @default.
• W2110885783 cites W2071543783 @default.
• W2110885783 cites W2074972748 @default.
• W2110885783 cites W2086428907 @default.
• W2110885783 cites W2087676247 @default.
• W2110885783 cites W2088104623 @default.
• W2110885783 cites W2089140880 @default.
• W2110885783 cites W2097658787 @default.
• W2110885783 cites W2102583008 @default.
• W2110885783 cites W2105018503 @default.
• W2110885783 cites W2117234353 @default.
• W2110885783 cites W2120080640 @default.
• W2110885783 cites W2131042197 @default.
• W2110885783 cites W2147318906 @default.
• W2110885783 cites W2152700250 @default.
• W2110885783 cites W2185168552 @default.
• W2110885783 cites W2468671133 @default.
• W2110885783 cites W4214826137 @default.
• W2110885783 cites W4243216764 @default.
• W2110885783 cites W4246290268 @default.
• W2110885783 cites W4254532271 @default.
• W2110885783 doi "https://doi.org/10.1113/jphysiol.2008.151746" @default.
• W2110885783 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2536575" @default.
• W2110885783 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18403422" @default.
• W2110885783 hasPublicationYear "2008" @default.
• W2110885783 type Work @default.
• W2110885783 sameAs 2110885783 @default.
• W2110885783 citedByCount "42" @default.
• W2110885783 countsByYear W21108857832012 @default.
• W2110885783 countsByYear W21108857832013 @default.
• W2110885783 countsByYear W21108857832014 @default.
• W2110885783 countsByYear W21108857832015 @default.
• W2110885783 countsByYear W21108857832016 @default.
• W2110885783 countsByYear W21108857832018 @default.
• W2110885783 countsByYear W21108857832019 @default.
• W2110885783 countsByYear W21108857832021 @default.
• W2110885783 countsByYear W21108857832022 @default.
• W2110885783 countsByYear W21108857832023 @default.
• W2110885783 crossrefType "journal-article" @default.
• W2110885783 hasAuthorship W2110885783A5071451071 @default.
• W2110885783 hasAuthorship W2110885783A5076911397 @default.
• W2110885783 hasAuthorship W2110885783A5084631284 @default.
• W2110885783 hasBestOaLocation W21108857832 @default.
• W2110885783 hasConcept C104211972 @default.
• W2110885783 hasConcept C105702510 @default.
• W2110885783 hasConcept C126322002 @default.
• W2110885783 hasConcept C15490471 @default.
• W2110885783 hasConcept C169760540 @default.
• W2110885783 hasConcept C170493617 @default.
• W2110885783 hasConcept C185592680 @default.
• W2110885783 hasConcept C2778640784 @default.
• W2110885783 hasConcept C2778828891 @default.
• W2110885783 hasConcept C2779263132 @default.
• W2110885783 hasConcept C3017567848 @default.
• W2110885783 hasConcept C42219234 @default.
• W2110885783 hasConcept C71924100 @default.
• W2110885783 hasConcept C86803240 @default.
• W2110885783 hasConcept C94487597 @default.
• W2110885783 hasConceptScore W2110885783C104211972 @default.
• W2110885783 hasConceptScore W2110885783C105702510 @default.
• W2110885783 hasConceptScore W2110885783C126322002 @default.
• W2110885783 hasConceptScore W2110885783C15490471 @default.
• W2110885783 hasConceptScore W2110885783C169760540 @default.
• W2110885783 hasConceptScore W2110885783C170493617 @default.
• W2110885783 hasConceptScore W2110885783C185592680 @default.

• next