Matches in SemOpenAlex for { <https://semopenalex.org/work/W2110888947> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W2110888947 endingPage "1156" @default.
- W2110888947 startingPage "1146" @default.
- W2110888947 abstract "Multiple gamma-glutamyl transpeptidase (GGT) messenger RNAs (mRNAsII-IV) are expressed in a region-specific manner in the rat epididymis. In the present study, we examined the role(s) of plasma testosterone (T) and testicular factors in regulating the region-specific pattern and quantity of GGT mRNAs expressed along the epididymal duct. Northern blot and ribonuclease protection analyses showed that bilateral orchiectomy for 1, 5, and 15 days dramatically reduced the expression of GGT mRNAsII-IV in the initial segment. Expression of GGT mRNAII and mRNAIII was maintained in the initial segment of orchiectomized animals receiving T implants that maintain normal serum T concentrations, but GGT mRNAIV expression remained low relative to sham-operated control values. Unilateral efferent duct ligation decreased GGT mRNAIV expression only in the initial segment. Hence, expression of GGT mRNAIV in the initial segment was not maintained by circulating T and required a factor(s) of testicular origin. In caput epididymidis, expression of GGT mRNAII and mRNAIII declined after orchiectomy and was not completely restored to control values in orchiectomized animals by plasma T alone, but also required a testicular factor(s). In contrast to the initial segment, expression of GGT mRNAIV in the corpus and cauda epididymidis did not require T and/or a testicular factor(s), as expression of this transcript remained unchanged in these regions after 1, 5, and 15 days of orchiectomy, orchiectomy and T replacement, and after unilateral efferent duct ligation. In the cauda epididymidis, expression of GGT mRNAII required circulating androgens and was unaffected by unilateral efferent duct ligation, whereas GGT mRNAIII expression was repressed by T. These data demonstrate that circulating T and a factor(s) of testicular origin differentially regulate the expression of each GGT mRNA in a region-specific manner." @default.
- W2110888947 created "2016-06-24" @default.
- W2110888947 creator A5000260833 @default.
- W2110888947 creator A5061012706 @default.
- W2110888947 date "1994-09-01" @default.
- W2110888947 modified "2023-10-02" @default.
- W2110888947 title "Expression of multiple gamma-glutamyl transpeptidase messenger ribonucleic acid transcripts in the adult rat epididymis is differentially regulated by androgens and testicular factors in a region-specific manner." @default.
- W2110888947 cites W149023422 @default.
- W2110888947 cites W1510979690 @default.
- W2110888947 cites W1511013913 @default.
- W2110888947 cites W1991091452 @default.
- W2110888947 cites W2105514622 @default.
- W2110888947 cites W2316993960 @default.
- W2110888947 doi "https://doi.org/10.1210/endo.135.3.7915228" @default.
- W2110888947 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7915228" @default.
- W2110888947 hasPublicationYear "1994" @default.
- W2110888947 type Work @default.
- W2110888947 sameAs 2110888947 @default.
- W2110888947 citedByCount "58" @default.
- W2110888947 countsByYear W21108889472014 @default.
- W2110888947 countsByYear W21108889472015 @default.
- W2110888947 countsByYear W21108889472016 @default.
- W2110888947 countsByYear W21108889472017 @default.
- W2110888947 countsByYear W21108889472019 @default.
- W2110888947 countsByYear W21108889472021 @default.
- W2110888947 countsByYear W21108889472022 @default.
- W2110888947 countsByYear W21108889472023 @default.
- W2110888947 crossrefType "journal-article" @default.
- W2110888947 hasAuthorship W2110888947A5000260833 @default.
- W2110888947 hasAuthorship W2110888947A5061012706 @default.
- W2110888947 hasConcept C104317684 @default.
- W2110888947 hasConcept C105580179 @default.
- W2110888947 hasConcept C126322002 @default.
- W2110888947 hasConcept C134018914 @default.
- W2110888947 hasConcept C150194340 @default.
- W2110888947 hasConcept C16685009 @default.
- W2110888947 hasConcept C179437574 @default.
- W2110888947 hasConcept C2778395058 @default.
- W2110888947 hasConcept C2781087480 @default.
- W2110888947 hasConcept C2781254305 @default.
- W2110888947 hasConcept C2781440318 @default.
- W2110888947 hasConcept C55493867 @default.
- W2110888947 hasConcept C59822182 @default.
- W2110888947 hasConcept C71924100 @default.
- W2110888947 hasConcept C86803240 @default.
- W2110888947 hasConceptScore W2110888947C104317684 @default.
- W2110888947 hasConceptScore W2110888947C105580179 @default.
- W2110888947 hasConceptScore W2110888947C126322002 @default.
- W2110888947 hasConceptScore W2110888947C134018914 @default.
- W2110888947 hasConceptScore W2110888947C150194340 @default.
- W2110888947 hasConceptScore W2110888947C16685009 @default.
- W2110888947 hasConceptScore W2110888947C179437574 @default.
- W2110888947 hasConceptScore W2110888947C2778395058 @default.
- W2110888947 hasConceptScore W2110888947C2781087480 @default.
- W2110888947 hasConceptScore W2110888947C2781254305 @default.
- W2110888947 hasConceptScore W2110888947C2781440318 @default.
- W2110888947 hasConceptScore W2110888947C55493867 @default.
- W2110888947 hasConceptScore W2110888947C59822182 @default.
- W2110888947 hasConceptScore W2110888947C71924100 @default.
- W2110888947 hasConceptScore W2110888947C86803240 @default.
- W2110888947 hasIssue "3" @default.
- W2110888947 hasLocation W21108889471 @default.
- W2110888947 hasLocation W21108889472 @default.
- W2110888947 hasOpenAccess W2110888947 @default.
- W2110888947 hasPrimaryLocation W21108889471 @default.
- W2110888947 hasRelatedWork W1971005192 @default.
- W2110888947 hasRelatedWork W1975058795 @default.
- W2110888947 hasRelatedWork W1980194808 @default.
- W2110888947 hasRelatedWork W1992906438 @default.
- W2110888947 hasRelatedWork W2003213334 @default.
- W2110888947 hasRelatedWork W2026148027 @default.
- W2110888947 hasRelatedWork W2062376659 @default.
- W2110888947 hasRelatedWork W2110888947 @default.
- W2110888947 hasRelatedWork W2400936979 @default.
- W2110888947 hasRelatedWork W2515188050 @default.
- W2110888947 hasVolume "135" @default.
- W2110888947 isParatext "false" @default.
- W2110888947 isRetracted "false" @default.
- W2110888947 magId "2110888947" @default.
- W2110888947 workType "article" @default.