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• W2110891503 abstract "Abstract The subfornical organ (SFO) is a circumventricular organ recognized for its ability to sense and integrate hydromineral and hormonal circulating fluid balance signals, information which is transmitted to central autonomic nuclei to which SFO neurons project. While the role of SFO was once synonymous with physiological responses to osmotic, volumetric and cardiovascular challenge, recent data suggest that SFO neurons also sense and integrate information from circulating signals of metabolic status. Using microarrays, we have confirmed the expression of receptors already described in the SFO, and identified many novel transcripts expressed in this circumventricular organ including receptors for many of the critical circulating energy balance signals such as adiponectin, apelin, endocannabinoids, leptin, insulin and peptide YY. This transcriptome analysis also identified SFO transcripts, the expressions of which are significantly changed by either 72 h dehydration, or 48 h starvation, compared to fed and euhydrated controls. Expression and potential roles for many of these targets are yet to be confirmed and elucidated. Subsequent validation of data for adiponectin and leptin receptors confirmed that receptors for both are expressed in the SFO, that discrete populations of neurons in this tissue are functionally responsive to these adipokines, and that such responsiveness is regulated by physiological state. Thus, transcriptomic analysis offers great promise for understanding the integrative complexity of these physiological systems, especially with development of technologies allowing description of the entire transcriptome of single, carefully phenotyped, SFO neurons. These data will ultimately elucidate mechanisms through which these uniquely positioned neurons respond to and integrate complex circulating signals. image" @default.
• W2110891503 created "2016-06-24" @default.
• W2110891503 creator A5014747183 @default.
• W2110891503 creator A5045866756 @default.
• W2110891503 date "2015-10-13" @default.
• W2110891503 modified "2023-10-12" @default.
• W2110891503 title "Physiological roles for the subfornical organ: a dynamic transcriptome shaped by autonomic state" @default.
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• W2110891503 doi "https://doi.org/10.1113/jp270726" @default.
• W2110891503 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4799992" @default.
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