FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2110909424> ?p ?o ?g. }

• W2110909424 endingPage "841" @default.
• W2110909424 startingPage "829" @default.
• W2110909424 abstract "The Aux/IAA genes are rapidly and specifically induced by the plant hormone auxin. The proteins encoded by this gene family are short-lived nuclear proteins that are capable of homodimerizing and heterodimerizing. Molecular, biochemical, and genetic data suggest that these proteins are involved in auxin signaling. The pleiotropic morphological phenotype and altered auxin responses of the semidominant axr3-1 mutant of Arabidopsis result from a single amino acid change in the conserved domain II of the Aux/IAA protein IAA17. Here, we show that the biochemical effect of this gain-of-function mutation is to increase the half-life of the iaa17/axr3-1 protein by sevenfold. Intragenic mutations that suppress the iaa17/axr3-1 phenotype have been described. The iaa17/axr3-1R3 revertant contains a second site mutation in domain I and the iaa17/axr3-1R2 revertant contains a second site mutation in domain III. Transient expression assays show that the mutant forms of IAA17/AXR3 retain the ability to accumulate in the nucleus. Using the yeast two hybrid system, we show that the iaa17/axr3-1 mutation does not affect homodimerization. However, the iaa17/axr3-1 revertants counteract the increased levels of iaa17/axr3-1 protein by decreasing the capacity of the mutant protein to homodimerize. Interestingly, heterodimerization of the revertant forms of IAA17/AXR3 with IAA3/SHY2, another Aux/IAA protein, and ARF1 or ARF5/MP proteins is affected only by changes in domain III. Collectively, the results provide biochemical evidence that the revertant mutations in the IAA17/AXR3 gene affect the capacity of the encoded protein to dimerize with itself, other members of the Aux/IAA protein family, and members of the ARF protein family. By extension, these findings may provide insight into the effects of analogous mutations in other members of the Aux/IAA gene family." @default.
• W2110909424 created "2016-06-24" @default.
• W2110909424 creator A5040607109 @default.
• W2110909424 creator A5079794685 @default.
• W2110909424 creator A5090711057 @default.
• W2110909424 date "2001-04-01" @default.
• W2110909424 modified "2023-10-02" @default.
• W2110909424 title "IAA17/AXR3: Biochemical Insight into an Auxin Mutant Phenotype" @default.
• W2110909424 cites W1918775481 @default.
• W2110909424 cites W1969673342 @default.
• W2110909424 cites W1975085160 @default.
• W2110909424 cites W1985476964 @default.
• W2110909424 cites W1990376824 @default.
• W2110909424 cites W1991911453 @default.
• W2110909424 cites W2007046681 @default.
• W2110909424 cites W2014669590 @default.
• W2110909424 cites W2023495459 @default.
• W2110909424 cites W2024683589 @default.
• W2110909424 cites W2034234820 @default.
• W2110909424 cites W2034504729 @default.
• W2110909424 cites W2047439787 @default.
• W2110909424 cites W2048441115 @default.
• W2110909424 cites W2048517444 @default.
• W2110909424 cites W2054262102 @default.
• W2110909424 cites W2054699569 @default.
• W2110909424 cites W2060052352 @default.
• W2110909424 cites W2062339374 @default.
• W2110909424 cites W2062682835 @default.
• W2110909424 cites W2065624112 @default.
• W2110909424 cites W2067519594 @default.
• W2110909424 cites W2069599291 @default.
• W2110909424 cites W2087997250 @default.
• W2110909424 cites W2089218510 @default.
• W2110909424 cites W2090275022 @default.
• W2110909424 cites W2092321617 @default.
• W2110909424 cites W2096694251 @default.
• W2110909424 cites W2115184998 @default.
• W2110909424 cites W2122141638 @default.
• W2110909424 cites W2138150898 @default.
• W2110909424 cites W2139053764 @default.
• W2110909424 cites W2142068049 @default.
• W2110909424 cites W2147882459 @default.
• W2110909424 cites W2150431323 @default.
• W2110909424 cites W2164465772 @default.
• W2110909424 doi "https://doi.org/10.1105/tpc.13.4.829" @default.
• W2110909424 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/135541" @default.
• W2110909424 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11283339" @default.
• W2110909424 hasPublicationYear "2001" @default.
• W2110909424 type Work @default.
• W2110909424 sameAs 2110909424 @default.
• W2110909424 citedByCount "264" @default.
• W2110909424 countsByYear W21109094242012 @default.
• W2110909424 countsByYear W21109094242013 @default.
• W2110909424 countsByYear W21109094242014 @default.
• W2110909424 countsByYear W21109094242015 @default.
• W2110909424 countsByYear W21109094242016 @default.
• W2110909424 countsByYear W21109094242017 @default.
• W2110909424 countsByYear W21109094242018 @default.
• W2110909424 countsByYear W21109094242019 @default.
• W2110909424 countsByYear W21109094242020 @default.
• W2110909424 countsByYear W21109094242021 @default.
• W2110909424 countsByYear W21109094242022 @default.
• W2110909424 countsByYear W21109094242023 @default.
• W2110909424 crossrefType "journal-article" @default.
• W2110909424 hasAuthorship W2110909424A5040607109 @default.
• W2110909424 hasAuthorship W2110909424A5079794685 @default.
• W2110909424 hasAuthorship W2110909424A5090711057 @default.
• W2110909424 hasBestOaLocation W21109094241 @default.
• W2110909424 hasConcept C104317684 @default.
• W2110909424 hasConcept C127716648 @default.
• W2110909424 hasConcept C143065580 @default.
• W2110909424 hasConcept C144292202 @default.
• W2110909424 hasConcept C207778908 @default.
• W2110909424 hasConcept C26567756 @default.
• W2110909424 hasConcept C2779491563 @default.
• W2110909424 hasConcept C29512474 @default.
• W2110909424 hasConcept C501734568 @default.
• W2110909424 hasConcept C54355233 @default.
• W2110909424 hasConcept C86339819 @default.
• W2110909424 hasConcept C86803240 @default.
• W2110909424 hasConcept C95444343 @default.
• W2110909424 hasConceptScore W2110909424C104317684 @default.
• W2110909424 hasConceptScore W2110909424C127716648 @default.
• W2110909424 hasConceptScore W2110909424C143065580 @default.
• W2110909424 hasConceptScore W2110909424C144292202 @default.
• W2110909424 hasConceptScore W2110909424C207778908 @default.
• W2110909424 hasConceptScore W2110909424C26567756 @default.
• W2110909424 hasConceptScore W2110909424C2779491563 @default.
• W2110909424 hasConceptScore W2110909424C29512474 @default.
• W2110909424 hasConceptScore W2110909424C501734568 @default.
• W2110909424 hasConceptScore W2110909424C54355233 @default.
• W2110909424 hasConceptScore W2110909424C86339819 @default.
• W2110909424 hasConceptScore W2110909424C86803240 @default.
• W2110909424 hasConceptScore W2110909424C95444343 @default.
• W2110909424 hasIssue "4" @default.
• W2110909424 hasLocation W21109094241 @default.
• W2110909424 hasLocation W21109094242 @default.
• W2110909424 hasLocation W21109094243 @default.

• next