FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2110912407> ?p ?o ?g. }

• W2110912407 endingPage "2850" @default.
• W2110912407 startingPage "2842" @default.
• W2110912407 abstract "In vitro maturation (IVM) of mammalian oocytes has potential health benefits for patients undergoing assisted reproduction as an alternative to gonadotrophin treatment. This procedure is also useful for studying the process of oocyte and early embryo development. However, oocytes undergoing IVM have much lower competence than in vivo matured oocytes. Efforts to optimize IVM success have focused on replicating in vivo timing, hormonal milieu and cumulus cell responses associated with maturing oocytes. We have previously identified two extracellular matrix proteins, the protease Adamts1 and hyaluronan-binding proteoglycan Versican, produced by mural granulosa cells that selectively incorporate into the periovulatory cumulus-oocyte complex (COC).Murine COC were cultured in the presence of epidermal growth factor and/or FSH. mRNA and protein were measured by real time PCR and Western blot and compared to in vivo derived COC.COCs from mice that underwent IVM for 6 or 20 h in the presence of epidermal growth factor, FSH or in combination had a > 10-fold reduction in mRNA (P < 0.05) for Adamts1 and Vcan when compared with in vivo matured COCs. Hyaluronan synthase 2 expression was up-regulated up to 8-fold (P < 0.05) over the unstimulated control, demonstrating successful induction of cumulus gene expression by the IVM conditions. While in vivo matured COCs showed abundant levels of these proteins, COCs that underwent IVM had neither detectable Adamts1, nor intact or Adamts1-cleaved Vcan. Human cumulus and granulosa cells matured in vivo contained abundant mRNA for Adamts1 and Vcan, demonstrating the potential relevance to human IVM.These results indicate that extensively altered COC matrix composition is present during IVM and may contribute to the observed poorer competence of the derived oocytes." @default.
• W2110912407 created "2016-06-24" @default.
• W2110912407 creator A5007839058 @default.
• W2110912407 creator A5062916923 @default.
• W2110912407 creator A5084688970 @default.
• W2110912407 creator A5085173358 @default.
• W2110912407 creator A5089363526 @default.
• W2110912407 creator A5091672817 @default.
• W2110912407 date "2007-09-27" @default.
• W2110912407 modified "2023-10-01" @default.
• W2110912407 title "Altered composition of the cumulus-oocyte complex matrix during in vitro maturation of oocytes" @default.
• W2110912407 cites W1502480664 @default.
• W2110912407 cites W1966582299 @default.
• W2110912407 cites W1981231686 @default.
• W2110912407 cites W1986193633 @default.
• W2110912407 cites W1997492405 @default.
• W2110912407 cites W1997955344 @default.
• W2110912407 cites W1998122821 @default.
• W2110912407 cites W1999600600 @default.
• W2110912407 cites W2000383236 @default.
• W2110912407 cites W2005339021 @default.
• W2110912407 cites W2016107310 @default.
• W2110912407 cites W2016570571 @default.
• W2110912407 cites W2017759961 @default.
• W2110912407 cites W2020264447 @default.
• W2110912407 cites W2022287786 @default.
• W2110912407 cites W2030771022 @default.
• W2110912407 cites W2032418626 @default.
• W2110912407 cites W2036878492 @default.
• W2110912407 cites W2044562326 @default.
• W2110912407 cites W2047083811 @default.
• W2110912407 cites W2051250694 @default.
• W2110912407 cites W2053483741 @default.
• W2110912407 cites W2066664707 @default.
• W2110912407 cites W2068505754 @default.
• W2110912407 cites W2076853816 @default.
• W2110912407 cites W2081351704 @default.
• W2110912407 cites W2082280903 @default.
• W2110912407 cites W2082795476 @default.
• W2110912407 cites W2084172300 @default.
• W2110912407 cites W2084940786 @default.
• W2110912407 cites W2085052924 @default.
• W2110912407 cites W2091789160 @default.
• W2110912407 cites W2099392253 @default.
• W2110912407 cites W2102134637 @default.
• W2110912407 cites W2104210113 @default.
• W2110912407 cites W2106270814 @default.
• W2110912407 cites W2107277218 @default.
• W2110912407 cites W2107461037 @default.
• W2110912407 cites W2107569607 @default.
• W2110912407 cites W2111508487 @default.
• W2110912407 cites W2115410748 @default.
• W2110912407 cites W2116761578 @default.
• W2110912407 cites W2121535505 @default.
• W2110912407 cites W2123939099 @default.
• W2110912407 cites W2127274198 @default.
• W2110912407 cites W2132363501 @default.
• W2110912407 cites W2133865055 @default.
• W2110912407 cites W2134799150 @default.
• W2110912407 cites W2135642925 @default.
• W2110912407 cites W2140579868 @default.
• W2110912407 cites W2152655092 @default.
• W2110912407 cites W2153461264 @default.
• W2110912407 cites W2157803698 @default.
• W2110912407 cites W2158253419 @default.
• W2110912407 cites W2158925842 @default.
• W2110912407 cites W2162314682 @default.
• W2110912407 cites W2168018194 @default.
• W2110912407 cites W2396062795 @default.
• W2110912407 cites W92134242 @default.
• W2110912407 doi "https://doi.org/10.1093/humrep/dem277" @default.
• W2110912407 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17872911" @default.
• W2110912407 hasPublicationYear "2007" @default.
• W2110912407 type Work @default.
• W2110912407 sameAs 2110912407 @default.
• W2110912407 citedByCount "67" @default.
• W2110912407 countsByYear W21109124072012 @default.
• W2110912407 countsByYear W21109124072013 @default.
• W2110912407 countsByYear W21109124072014 @default.
• W2110912407 countsByYear W21109124072015 @default.
• W2110912407 countsByYear W21109124072016 @default.
• W2110912407 countsByYear W21109124072017 @default.
• W2110912407 countsByYear W21109124072018 @default.
• W2110912407 countsByYear W21109124072019 @default.
• W2110912407 countsByYear W21109124072020 @default.
• W2110912407 countsByYear W21109124072021 @default.
• W2110912407 countsByYear W21109124072022 @default.
• W2110912407 countsByYear W21109124072023 @default.
• W2110912407 crossrefType "journal-article" @default.
• W2110912407 hasAuthorship W2110912407A5007839058 @default.
• W2110912407 hasAuthorship W2110912407A5062916923 @default.
• W2110912407 hasAuthorship W2110912407A5084688970 @default.
• W2110912407 hasAuthorship W2110912407A5085173358 @default.
• W2110912407 hasAuthorship W2110912407A5089363526 @default.
• W2110912407 hasAuthorship W2110912407A5091672817 @default.
• W2110912407 hasConcept C159470946 @default.
• W2110912407 hasConcept C16685009 @default.
• W2110912407 hasConcept C185592680 @default.

• next