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• W2110921202 endingPage "271" @default.
• W2110921202 startingPage "249" @default.
• W2110921202 abstract "The efficient delivery of therapeutic genes and appropriate gene expression are the crucial issues for clinically relevant gene therapy. Viruses are naturally evolved vehicles which efficiently transfer their genes into host cells. This ability made them desirable for engineering virus vector systems for the delivery of therapeutic genes. The viral vectors recently in laboratory and clinical use are based on RNA and DNA viruses processing very different genomic structures and host ranges. Particular viruses have been selected as gene delivery vehicles because of their capacities to carry foreign genes and their ability to efficiently deliver these genes associated with efficient gene expression. These are the major reasons why viral vectors derived from retroviruses, adenovirus, adeno-associated virus, herpesvirus and poxvirus are employed in more than 70% of clinical gene therapy trials worldwide. Among these vector systems, retrovirus vectors represent the most prominent delivery system, since these vectors have high gene transfer efficiency and mediate high expression of therapeutic genes. Members of the DNA virus family such as adenovirus-, adeno-associated virus or herpesvirus have also become attractive for efficient gene delivery as reflected by the fast growing number of clinical trials using these vectors. The first clinical trials were designed to test the feasibility and safety of viral vectors. Numerous viral vector systems have been developed for ex vivo and in vivo applications. More recently, increasing efforts have been made to improve infectivity, viral targeting, cell type specific expression and the duration of expression. These features are essential for higher efficacy and safety of RNA- and DNA-virus vectors. From the beginning of development and utilisation of viral vectors it was apparent that they harbour risks such as toxicities, immunoresponses towards viral antigens or potential viral recombination, which limit their clinical use. However, many achievements have been made in vector safety, the retargeting of virus vectors and improving the expression properties by refining vector design and virus production. This review addresses important issues of the current status of viral vector design and discusses their key features as delivery systems in gene therapy of human inherited and acquired diseases at the level of laboratory developments and of clinical applications." @default.
• W2110921202 created "2016-06-24" @default.
• W2110921202 creator A5002853916 @default.
• W2110921202 creator A5031474036 @default.
• W2110921202 date "2000-08-01" @default.
• W2110921202 modified "2023-10-14" @default.
• W2110921202 title "Viral Vectors for Gene Transfer" @default.
• W2110921202 cites W107359748 @default.
• W2110921202 cites W1510327054 @default.
• W2110921202 cites W1510346473 @default.
• W2110921202 cites W1588659566 @default.
• W2110921202 cites W1604403292 @default.
• W2110921202 cites W161238046 @default.
• W2110921202 cites W1616735705 @default.
• W2110921202 cites W1640609127 @default.
• W2110921202 cites W1670526549 @default.
• W2110921202 cites W1686812758 @default.
• W2110921202 cites W170859630 @default.
• W2110921202 cites W1716707690 @default.
• W2110921202 cites W1732481302 @default.
• W2110921202 cites W1750539994 @default.
• W2110921202 cites W1756236371 @default.
• W2110921202 cites W1811276736 @default.
• W2110921202 cites W1812073825 @default.
• W2110921202 cites W1889284243 @default.
• W2110921202 cites W1907043719 @default.
• W2110921202 cites W1918960237 @default.
• W2110921202 cites W1929630117 @default.
• W2110921202 cites W1947669382 @default.
• W2110921202 cites W1962142522 @default.
• W2110921202 cites W1967357094 @default.
• W2110921202 cites W1967380633 @default.
• W2110921202 cites W1969785946 @default.
• W2110921202 cites W1969941346 @default.
• W2110921202 cites W1970212185 @default.
• W2110921202 cites W1971629708 @default.
• W2110921202 cites W1973862460 @default.
• W2110921202 cites W1976215218 @default.
• W2110921202 cites W1977453669 @default.
• W2110921202 cites W1977638337 @default.
• W2110921202 cites W1980111025 @default.
• W2110921202 cites W1980477679 @default.
• W2110921202 cites W1984034322 @default.
• W2110921202 cites W1988341070 @default.
• W2110921202 cites W1990561446 @default.
• W2110921202 cites W1991735449 @default.
• W2110921202 cites W1991851022 @default.
• W2110921202 cites W2000423780 @default.
• W2110921202 cites W2006029795 @default.
• W2110921202 cites W2006253272 @default.
• W2110921202 cites W2006519535 @default.
• W2110921202 cites W2007153121 @default.
• W2110921202 cites W2007854533 @default.
• W2110921202 cites W2008685326 @default.
• W2110921202 cites W2009761723 @default.
• W2110921202 cites W2011206688 @default.
• W2110921202 cites W2015617337 @default.
• W2110921202 cites W2016080258 @default.
• W2110921202 cites W2016777908 @default.
• W2110921202 cites W2019814860 @default.
• W2110921202 cites W2021116207 @default.
• W2110921202 cites W2024912868 @default.
• W2110921202 cites W2025134240 @default.
• W2110921202 cites W2026641742 @default.
• W2110921202 cites W2026699829 @default.
• W2110921202 cites W2026842355 @default.
• W2110921202 cites W2026854040 @default.
• W2110921202 cites W2028067246 @default.
• W2110921202 cites W2032678451 @default.
• W2110921202 cites W2034629037 @default.
• W2110921202 cites W2035668312 @default.
• W2110921202 cites W2038036971 @default.
• W2110921202 cites W2041196737 @default.
• W2110921202 cites W2044294583 @default.
• W2110921202 cites W2044296969 @default.
• W2110921202 cites W2045336921 @default.
• W2110921202 cites W2045957511 @default.
• W2110921202 cites W2047942455 @default.
• W2110921202 cites W2048266048 @default.
• W2110921202 cites W2048303863 @default.
• W2110921202 cites W2048326720 @default.
• W2110921202 cites W2050193680 @default.
• W2110921202 cites W2051442157 @default.
• W2110921202 cites W2052406246 @default.
• W2110921202 cites W2055047899 @default.
• W2110921202 cites W2055825871 @default.
• W2110921202 cites W2056657026 @default.
• W2110921202 cites W2062723580 @default.
• W2110921202 cites W2063049455 @default.
• W2110921202 cites W2064166253 @default.
• W2110921202 cites W2068752450 @default.
• W2110921202 cites W2070287179 @default.
• W2110921202 cites W2071150424 @default.
• W2110921202 cites W2071171955 @default.
• W2110921202 cites W2071763225 @default.
• W2110921202 cites W2071785782 @default.
• W2110921202 cites W2071897763 @default.
• W2110921202 cites W2072295407 @default.

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