FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2110921609> ?p ?o ?g. }

• W2110921609 endingPage "433" @default.
• W2110921609 startingPage "403" @default.
• W2110921609 abstract "Abstract The objective of this paper is to investigate dynamic properties of age trajectories of physiological indices and their effects on mortality risk and longevity using longitudinal data on more than 5,000 individuals collected in biennial examinations of the Framingham Heart Study (FHS) original cohort during about 50 subsequent years of follow-up. We first performed empirical analyses of the FHS longitudinal data. We evaluated average age trajectories of indices describing physiological states for different groups of individuals and established their connections with mortality risk. These indices include body mass index, diastolic blood pressure, pulse pressure, pulse rate, level of blood glucose, hematocrit, and serum cholesterol. To be able to investigate dynamic mechanisms responsible for changes in the aging human organisms using available longitudinal data, we further developed a stochastic process model of human mortality and aging, by including in it the notions of “physiological norms,” “allostatic adaptation and allostatic load,” “stress resistance,” and other characteristics associated with the internal process of aging and the effects of external disturbances. In this model, the persistent deviation of physiological indices from their normal values contributes to an increase in morbidity and mortality risks. We used the stochastic process model in the statistical analyses of longitudinal FHS data. We found that different indices have different average age patterns and different dynamic properties. We also found that age trajectories of long-lived individuals differ from those of the shorter-lived members of the FHS original cohort for both sexes. Using methods of statistical modeling, we evaluated “normal” age trajectories of physiological indices and the dynamic effects of allostatic adaptation. The model allows for evaluating average patterns of aging-related decline in stress resistance. This effect is captured by the narrowing of the U-shaped mortality risk (considered a function of physiological state) with age. We showed that individual indices and their rates of change with age, as well as other measures of individual variability, manifested during the life course are important contributors to mortality risks. The advantages and limitations of the approach are discussed." @default.
• W2110921609 created "2016-06-24" @default.
• W2110921609 creator A5017898754 @default.
• W2110921609 creator A5018208097 @default.
• W2110921609 creator A5049441585 @default.
• W2110921609 creator A5051786764 @default.
• W2110921609 creator A5085542503 @default.
• W2110921609 date "2012-10-01" @default.
• W2110921609 modified "2023-09-27" @default.
• W2110921609 title "Patterns of Aging-Related Changes on the Way to 100" @default.
• W2110921609 cites W1544496977 @default.
• W2110921609 cites W1974972799 @default.
• W2110921609 cites W1981748148 @default.
• W2110921609 cites W1988643163 @default.
• W2110921609 cites W1990667054 @default.
• W2110921609 cites W1994969712 @default.
• W2110921609 cites W1995889062 @default.
• W2110921609 cites W1997919233 @default.
• W2110921609 cites W1999212197 @default.
• W2110921609 cites W2014182983 @default.
• W2110921609 cites W2021229835 @default.
• W2110921609 cites W2021701588 @default.
• W2110921609 cites W2032138124 @default.
• W2110921609 cites W2035459227 @default.
• W2110921609 cites W2036419021 @default.
• W2110921609 cites W2037418922 @default.
• W2110921609 cites W2039816778 @default.
• W2110921609 cites W2042276707 @default.
• W2110921609 cites W2042766570 @default.
• W2110921609 cites W2047868073 @default.
• W2110921609 cites W2048092130 @default.
• W2110921609 cites W2049029699 @default.
• W2110921609 cites W2049349831 @default.
• W2110921609 cites W2053596510 @default.
• W2110921609 cites W2060733516 @default.
• W2110921609 cites W2061195953 @default.
• W2110921609 cites W2081604967 @default.
• W2110921609 cites W2083384274 @default.
• W2110921609 cites W2086332688 @default.
• W2110921609 cites W2090301552 @default.
• W2110921609 cites W2101990128 @default.
• W2110921609 cites W2108356524 @default.
• W2110921609 cites W2113854409 @default.
• W2110921609 cites W2125576474 @default.
• W2110921609 cites W2131952161 @default.
• W2110921609 cites W2135947850 @default.
• W2110921609 cites W2144494932 @default.
• W2110921609 cites W2148341801 @default.
• W2110921609 cites W2153555709 @default.
• W2110921609 cites W2159238709 @default.
• W2110921609 cites W2160942312 @default.
• W2110921609 cites W2161289428 @default.
• W2110921609 cites W2161315307 @default.
• W2110921609 cites W2170021722 @default.
• W2110921609 cites W2208740363 @default.
• W2110921609 cites W2500401315 @default.
• W2110921609 cites W3125795336 @default.
• W2110921609 cites W4214940043 @default.
• W2110921609 cites W4322697744 @default.
• W2110921609 doi "https://doi.org/10.1080/10920277.2012.10597640" @default.
• W2110921609 hasPublicationYear "2012" @default.
• W2110921609 type Work @default.
• W2110921609 sameAs 2110921609 @default.
• W2110921609 citedByCount "16" @default.
• W2110921609 countsByYear W21109216092012 @default.
• W2110921609 countsByYear W21109216092013 @default.
• W2110921609 countsByYear W21109216092014 @default.
• W2110921609 countsByYear W21109216092016 @default.
• W2110921609 countsByYear W21109216092017 @default.
• W2110921609 countsByYear W21109216092018 @default.
• W2110921609 countsByYear W21109216092019 @default.
• W2110921609 countsByYear W21109216092020 @default.
• W2110921609 countsByYear W21109216092023 @default.
• W2110921609 crossrefType "journal-article" @default.
• W2110921609 hasAuthorship W2110921609A5017898754 @default.
• W2110921609 hasAuthorship W2110921609A5018208097 @default.
• W2110921609 hasAuthorship W2110921609A5049441585 @default.
• W2110921609 hasAuthorship W2110921609A5051786764 @default.
• W2110921609 hasAuthorship W2110921609A5085542503 @default.
• W2110921609 hasConcept C105795698 @default.
• W2110921609 hasConcept C111815664 @default.
• W2110921609 hasConcept C11783203 @default.
• W2110921609 hasConcept C126322002 @default.
• W2110921609 hasConcept C144024400 @default.
• W2110921609 hasConcept C149923435 @default.
• W2110921609 hasConcept C157541749 @default.
• W2110921609 hasConcept C187150481 @default.
• W2110921609 hasConcept C203014093 @default.
• W2110921609 hasConcept C2777895361 @default.
• W2110921609 hasConcept C2779134260 @default.
• W2110921609 hasConcept C2780221984 @default.
• W2110921609 hasConcept C33923547 @default.
• W2110921609 hasConcept C71924100 @default.
• W2110921609 hasConcept C72563966 @default.
• W2110921609 hasConcept C74909509 @default.
• W2110921609 hasConcept C84393581 @default.
• W2110921609 hasConceptScore W2110921609C105795698 @default.
• W2110921609 hasConceptScore W2110921609C111815664 @default.

• next