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• W2110921852 startingPage "79" @default.
• W2110921852 abstract "Before the roles of normal, mature astrocytes in the mammalian CNS can be discussed, we first need to define these cells. A definition proposed here is that such a class is best defined as consisting of the protoplasmic and fibrous astrocytes of the gray and white matter, respectively, the Bergmann glia of the molecular layer of the cerebellum, and the Muller cells of the retina. It is concluded that the established properties and functions of these mature astrocytes are essential support for neuronal activity, in the sense of Claude Bernard's principle of maintaining la fixité du milieu intérieur. This milieu would be the extracellular space common to astrocytes and neurons. More specialized roles, such as the recently described light guides for retinal Muller cells can also be viewed as support and facilitation. The ECS is also, of course, common to all other neural cells, but here, I limit the discussion to perturbations of the ECS caused only by neuronal activities and the resolution of these perturbations by astrocytes, such as control of increases in extracellular K(+), uptake of excitatory amino acids, and alterations in blood vessel diameter and therefore blood flow. It is also proposed how this fits into the current morphological picture for the protoplasmic astrocytes as having small cell bodies with up to 100,000 process endings that occupy separate territories on which the processes of neighboring astrocytes scarcely intrude." @default.
• W2110921852 created "2016-06-24" @default.
• W2110921852 creator A5007026581 @default.
• W2110921852 date "2010-02-01" @default.
• W2110921852 modified "2023-09-26" @default.
• W2110921852 title "Functions of Mature Mammalian Astrocytes: A Current View" @default.
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