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- W2110922022 abstract "Sir,A 33-year-old woman presented with a week's history of progressive backache, weakness and dysphagia. The onset of her symptoms coincided with tapering of 4-week course of oral corticosteroids (prednisolone), which was instituted to treat a severe pneumonic illness requiring admission to intensive care and a short period of assisted ventilation. She did not have any previous history of obstructive airways or interstitial pulmonary disease. Her respiratory illness was presumed to be due to viral pneumonia but no serological or microbiological evidence for infection was identified. She was diagnosed with Crohn's disease since as a child, based on histology of her colonoscopic biopsy. The bowel disease was quiescent for many years and she was essentially asymptomatic for Crohn's disease at presentation. She also suffered from asthma, which was well controlled on regular use of inhaled steroids and beta agonists.On this occasion, she had developed progressive muscle weakness. She could not roll over in bed, lift her arms or rise. She also noted difficulty with swallowing both liquids and solids. Clinical examination at the Accident and Emergency department showed mild bifacial weakness, dysarthria and weak cough. She was tachypnoeic with a respiratory rate of 25 breaths per minute. Limb examination revealed globally flaccid tone and profound proximal weakness (MRC 1/5). Forced vital capacity was <1 l and arterial blood gas examination …" @default.
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- W2110922022 date "2008-01-25" @default.
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- W2110922022 title "Respiratory muscle weakness in a patient with quiescent Crohn's disease and pneumonia" @default.
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- W2110922022 doi "https://doi.org/10.1093/qjmed/hcn005" @default.
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