Matches in SemOpenAlex for { <https://semopenalex.org/work/W2110957040> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W2110957040 endingPage "2060" @default.
- W2110957040 startingPage "2057" @default.
- W2110957040 abstract "Rationale Use of matrix‐assisted laser desorption/ionization time‐of‐flight mass spectrometry (MALDI‐TOFMS) to monitor serum and urine samples for endogenous monoclonal immunoglobulins. MALDI‐TOFMS is faster, fully automatable, and provides superior specificity compared to protein gel electrophoresis (PEL). Methods Samples were enriched for immunoglobulins in 5 min using Melon Gel™ followed by reduction with dithiothreitol for 15 min to separate immunoglobulin light chains and heavy chains. Samples were then desalted using C4 ZipTips, mixed with sinapinic acid matrix, and analyzed on a Bruker Biflex III MALDI‐TOF mass spectrometer. Results Monoclonal immunoglobulin light chains were identified in serum and urine samples from patients with a known monoclonal gammopathy using MALDI‐TOFMS with minimal sample preparation. Conclusions MALDI‐TOFMS can identify a monoclonal immunoglobulin in serum and urine samples. The molecular mass of the monoclonal immunoglobulin light chain is obtained providing unprecedented specificity compared to PEL. In addition, the methodology can be automated, making it a practical alternative to PEL. Copyright © 2015 John Wiley & Sons, Ltd." @default.
- W2110957040 created "2016-06-24" @default.
- W2110957040 creator A5006847890 @default.
- W2110957040 creator A5017175864 @default.
- W2110957040 creator A5051563559 @default.
- W2110957040 creator A5060771598 @default.
- W2110957040 date "2015-09-28" @default.
- W2110957040 modified "2023-10-16" @default.
- W2110957040 title "Using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry to detect monoclonal immunoglobulin light chains in serum and urine" @default.
- W2110957040 cites W1976651915 @default.
- W2110957040 cites W2012489593 @default.
- W2110957040 cites W2055374820 @default.
- W2110957040 cites W2088762162 @default.
- W2110957040 cites W2094860451 @default.
- W2110957040 cites W2120929463 @default.
- W2110957040 cites W2145503040 @default.
- W2110957040 cites W2171206481 @default.
- W2110957040 cites W2325138686 @default.
- W2110957040 cites W2333934799 @default.
- W2110957040 doi "https://doi.org/10.1002/rcm.7314" @default.
- W2110957040 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26443406" @default.
- W2110957040 hasPublicationYear "2015" @default.
- W2110957040 type Work @default.
- W2110957040 sameAs 2110957040 @default.
- W2110957040 citedByCount "21" @default.
- W2110957040 countsByYear W21109570402016 @default.
- W2110957040 countsByYear W21109570402017 @default.
- W2110957040 countsByYear W21109570402019 @default.
- W2110957040 countsByYear W21109570402020 @default.
- W2110957040 countsByYear W21109570402021 @default.
- W2110957040 countsByYear W21109570402022 @default.
- W2110957040 crossrefType "journal-article" @default.
- W2110957040 hasAuthorship W2110957040A5006847890 @default.
- W2110957040 hasAuthorship W2110957040A5017175864 @default.
- W2110957040 hasAuthorship W2110957040A5051563559 @default.
- W2110957040 hasAuthorship W2110957040A5060771598 @default.
- W2110957040 hasConcept C145148216 @default.
- W2110957040 hasConcept C150394285 @default.
- W2110957040 hasConcept C159654299 @default.
- W2110957040 hasConcept C162356407 @default.
- W2110957040 hasConcept C162711632 @default.
- W2110957040 hasConcept C16291436 @default.
- W2110957040 hasConcept C163864487 @default.
- W2110957040 hasConcept C178790620 @default.
- W2110957040 hasConcept C185592680 @default.
- W2110957040 hasConcept C198291218 @default.
- W2110957040 hasConcept C203014093 @default.
- W2110957040 hasConcept C2780026642 @default.
- W2110957040 hasConcept C36394416 @default.
- W2110957040 hasConcept C43617362 @default.
- W2110957040 hasConcept C542903549 @default.
- W2110957040 hasConcept C55493867 @default.
- W2110957040 hasConcept C75280812 @default.
- W2110957040 hasConcept C86803240 @default.
- W2110957040 hasConceptScore W2110957040C145148216 @default.
- W2110957040 hasConceptScore W2110957040C150394285 @default.
- W2110957040 hasConceptScore W2110957040C159654299 @default.
- W2110957040 hasConceptScore W2110957040C162356407 @default.
- W2110957040 hasConceptScore W2110957040C162711632 @default.
- W2110957040 hasConceptScore W2110957040C16291436 @default.
- W2110957040 hasConceptScore W2110957040C163864487 @default.
- W2110957040 hasConceptScore W2110957040C178790620 @default.
- W2110957040 hasConceptScore W2110957040C185592680 @default.
- W2110957040 hasConceptScore W2110957040C198291218 @default.
- W2110957040 hasConceptScore W2110957040C203014093 @default.
- W2110957040 hasConceptScore W2110957040C2780026642 @default.
- W2110957040 hasConceptScore W2110957040C36394416 @default.
- W2110957040 hasConceptScore W2110957040C43617362 @default.
- W2110957040 hasConceptScore W2110957040C542903549 @default.
- W2110957040 hasConceptScore W2110957040C55493867 @default.
- W2110957040 hasConceptScore W2110957040C75280812 @default.
- W2110957040 hasConceptScore W2110957040C86803240 @default.
- W2110957040 hasIssue "21" @default.
- W2110957040 hasLocation W21109570401 @default.
- W2110957040 hasLocation W21109570402 @default.
- W2110957040 hasOpenAccess W2110957040 @default.
- W2110957040 hasPrimaryLocation W21109570401 @default.
- W2110957040 hasRelatedWork W1966323553 @default.
- W2110957040 hasRelatedWork W1988865553 @default.
- W2110957040 hasRelatedWork W2031383172 @default.
- W2110957040 hasRelatedWork W2097157035 @default.
- W2110957040 hasRelatedWork W2178864683 @default.
- W2110957040 hasRelatedWork W2939092888 @default.
- W2110957040 hasRelatedWork W3016055260 @default.
- W2110957040 hasRelatedWork W3096888398 @default.
- W2110957040 hasRelatedWork W4249113282 @default.
- W2110957040 hasRelatedWork W2188849688 @default.
- W2110957040 hasVolume "29" @default.
- W2110957040 isParatext "false" @default.
- W2110957040 isRetracted "false" @default.
- W2110957040 magId "2110957040" @default.
- W2110957040 workType "article" @default.