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- W2110961503 endingPage "369" @default.
- W2110961503 startingPage "361" @default.
- W2110961503 abstract "In patients with cystic fibrosis (CF), respiratory infections with the opportunistic bacterial pathogen Pseudomonas aeruginosa have a major impact on morbidity and mortality. Aminoglycosides, especially tobramycin, have been used successfully to combat these infections. Aminoglycoside penetration of bronchial secretions is poor when the antibiotic is administered intravenously. Nebulization allows direct delivery of the drug to the sites of infection within the airways, while avoiding systemic exposure. Published clinical data show that inhaled tobramycin reduces the bacterial load, improves lung function and reduces the number of hospital admissions. Inhaled tobramycin has been used successfully to eradicate P. aeruginosa in patients with early infection. Maintaining clinical benefits requires chronic tobramycin treatment, and the concept of chronic intermittent inhaled treatment (typically, alternating drug and drug-free periods of 28 days) was introduced to minimize the emergence of aminoglycoside resistant P. aeruginosa strains. Other therapeutic advances include the development of different tobramycin formulations and nebulizers that reduce delivery time without compromising efficacy. An optimal treatment regimen for patients with CF with early or intermittent P. aeruginosa infections remains a high priority to maintain long-term lung health." @default.
- W2110961503 created "2016-06-24" @default.
- W2110961503 creator A5015871222 @default.
- W2110961503 creator A5017024281 @default.
- W2110961503 creator A5042413377 @default.
- W2110961503 date "2009-12-01" @default.
- W2110961503 modified "2023-09-25" @default.
- W2110961503 title "Aminoglycoside therapy against Pseudomonas aeruginosa in cystic fibrosis: A review" @default.
- W2110961503 cites W1598072106 @default.
- W2110961503 cites W1911569221 @default.
- W2110961503 cites W1966949405 @default.
- W2110961503 cites W1968479003 @default.
- W2110961503 cites W1968602861 @default.
- W2110961503 cites W1970834330 @default.
- W2110961503 cites W1971558827 @default.
- W2110961503 cites W1972714977 @default.
- W2110961503 cites W1984655462 @default.
- W2110961503 cites W1985242328 @default.
- W2110961503 cites W1985687704 @default.
- W2110961503 cites W1987865402 @default.
- W2110961503 cites W1989961653 @default.
- W2110961503 cites W1990336663 @default.
- W2110961503 cites W1998612252 @default.
- W2110961503 cites W1999260607 @default.
- W2110961503 cites W2000175374 @default.
- W2110961503 cites W2005628229 @default.
- W2110961503 cites W2007203304 @default.
- W2110961503 cites W2009959447 @default.
- W2110961503 cites W2020366537 @default.
- W2110961503 cites W2022634662 @default.
- W2110961503 cites W2027723289 @default.
- W2110961503 cites W2030631267 @default.
- W2110961503 cites W2032808656 @default.
- W2110961503 cites W2032940647 @default.
- W2110961503 cites W2033241761 @default.
- W2110961503 cites W2033379900 @default.
- W2110961503 cites W2036439055 @default.
- W2110961503 cites W2042916674 @default.
- W2110961503 cites W2046513922 @default.
- W2110961503 cites W2046888465 @default.
- W2110961503 cites W2054585332 @default.
- W2110961503 cites W2055753580 @default.
- W2110961503 cites W2057061730 @default.
- W2110961503 cites W2057496127 @default.
- W2110961503 cites W2061909665 @default.
- W2110961503 cites W2062895955 @default.
- W2110961503 cites W2065933810 @default.
- W2110961503 cites W2068148539 @default.
- W2110961503 cites W2068781163 @default.
- W2110961503 cites W2069757343 @default.
- W2110961503 cites W2070458418 @default.
- W2110961503 cites W2078092799 @default.
- W2110961503 cites W2083109379 @default.
- W2110961503 cites W2085033676 @default.
- W2110961503 cites W2088411382 @default.
- W2110961503 cites W2089549091 @default.
- W2110961503 cites W2090229932 @default.
- W2110961503 cites W2091437562 @default.
- W2110961503 cites W2094529238 @default.
- W2110961503 cites W2097575804 @default.
- W2110961503 cites W2098645786 @default.
- W2110961503 cites W2100596772 @default.
- W2110961503 cites W2100739350 @default.
- W2110961503 cites W2101667079 @default.
- W2110961503 cites W2105443867 @default.
- W2110961503 cites W2105915947 @default.
- W2110961503 cites W2109082343 @default.
- W2110961503 cites W2109399497 @default.
- W2110961503 cites W2109939030 @default.
- W2110961503 cites W2111770397 @default.
- W2110961503 cites W2114939043 @default.
- W2110961503 cites W2117472380 @default.
- W2110961503 cites W2120857717 @default.
- W2110961503 cites W2123193104 @default.
- W2110961503 cites W2127170823 @default.
- W2110961503 cites W2128547781 @default.
- W2110961503 cites W2129122463 @default.
- W2110961503 cites W2130878552 @default.
- W2110961503 cites W2131539997 @default.
- W2110961503 cites W2132859657 @default.
- W2110961503 cites W2140801627 @default.
- W2110961503 cites W2142191352 @default.
- W2110961503 cites W2142648608 @default.
- W2110961503 cites W2144238086 @default.
- W2110961503 cites W2147898933 @default.
- W2110961503 cites W2148491414 @default.
- W2110961503 cites W2152950101 @default.
- W2110961503 cites W2153054845 @default.
- W2110961503 cites W2154016364 @default.
- W2110961503 cites W2155069031 @default.
- W2110961503 cites W2155681864 @default.
- W2110961503 cites W2159814661 @default.
- W2110961503 cites W2164471608 @default.
- W2110961503 cites W2166059037 @default.
- W2110961503 cites W2166779461 @default.
- W2110961503 cites W2167343535 @default.
- W2110961503 cites W2169006900 @default.
- W2110961503 cites W2169221816 @default.