FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2110971717> ?p ?o ?g. }

• W2110971717 endingPage "175" @default.
• W2110971717 startingPage "164" @default.
• W2110971717 abstract "The yeast cell wall is an extracellular structure that is dependent on secretory and membrane proteins for its construction. We investigated the role of protein quality control mechanisms in cell wall integrity and found that the unfolded protein response (UPR) and, to a lesser extent, endoplasmic reticulum (ER)-associated degradation (ERAD) pathways are required for proper cell wall construction. Null mutation of IRE1, double mutation of ERAD components (hrd1Delta and ubc7Delta) and ire1Delta, or expression of misfolded proteins show phenotypes similar to mutation of cell wall proteins, including hypersensitivity to cell wall-targeted molecules, alterations to cell wall protein layer, decreased cell wall thickness by electron microscopy, and increased cellular aggregation. Consistent with its important role in cell wall integrity, UPR is activated by signaling through the cell wall integrity mitogen-activated protein (MAP) kinase pathway during cell wall stress and unstressed vegetative growth. Both cell wall stress and basal UPR activity is mediated by Swi6p, a regulator of cell cycle and cell wall stress gene transcription, in a manner that is independent of its known coregulatory molecules. We propose that the cellular responses to ER and cell wall stress are coordinated to buffer the cell against these two related cellular stresses." @default.
• W2110971717 created "2016-06-24" @default.
• W2110971717 creator A5002847510 @default.
• W2110971717 creator A5024328245 @default.
• W2110971717 creator A5030685089 @default.
• W2110971717 creator A5076058258 @default.
• W2110971717 date "2009-01-01" @default.
• W2110971717 modified "2023-10-05" @default.
• W2110971717 title "The Unfolded Protein Response Is Induced by the Cell Wall Integrity Mitogen-activated Protein Kinase Signaling Cascade and Is Required for Cell Wall Integrity in<i>Saccharomyces cerevisiae</i>" @default.
• W2110971717 cites W1575978940 @default.
• W2110971717 cites W1588192538 @default.
• W2110971717 cites W181622860 @default.
• W2110971717 cites W1940766041 @default.
• W2110971717 cites W1969277030 @default.
• W2110971717 cites W1969955354 @default.
• W2110971717 cites W1971622025 @default.
• W2110971717 cites W1981551685 @default.
• W2110971717 cites W1982853817 @default.
• W2110971717 cites W1984347348 @default.
• W2110971717 cites W1990400035 @default.
• W2110971717 cites W2005504138 @default.
• W2110971717 cites W2009741382 @default.
• W2110971717 cites W2011092157 @default.
• W2110971717 cites W2012371717 @default.
• W2110971717 cites W2019904364 @default.
• W2110971717 cites W2032018179 @default.
• W2110971717 cites W2035192291 @default.
• W2110971717 cites W204275195 @default.
• W2110971717 cites W2046640957 @default.
• W2110971717 cites W2051881845 @default.
• W2110971717 cites W2053274242 @default.
• W2110971717 cites W2053383151 @default.
• W2110971717 cites W2055641030 @default.
• W2110971717 cites W2055993297 @default.
• W2110971717 cites W2064059521 @default.
• W2110971717 cites W2069350458 @default.
• W2110971717 cites W2071722315 @default.
• W2110971717 cites W2073912363 @default.
• W2110971717 cites W2076774576 @default.
• W2110971717 cites W2080492298 @default.
• W2110971717 cites W2082605090 @default.
• W2110971717 cites W2082799239 @default.
• W2110971717 cites W2089198803 @default.
• W2110971717 cites W2094923559 @default.
• W2110971717 cites W2098109141 @default.
• W2110971717 cites W2106188607 @default.
• W2110971717 cites W2106860332 @default.
• W2110971717 cites W2106983618 @default.
• W2110971717 cites W2120638418 @default.
• W2110971717 cites W2128736789 @default.
• W2110971717 cites W2129448720 @default.
• W2110971717 cites W2137755719 @default.
• W2110971717 cites W2139584811 @default.
• W2110971717 cites W2140518858 @default.
• W2110971717 cites W2140619162 @default.
• W2110971717 cites W2144036800 @default.
• W2110971717 cites W2145427143 @default.
• W2110971717 cites W2148125211 @default.
• W2110971717 cites W2148652865 @default.
• W2110971717 cites W2150610841 @default.
• W2110971717 cites W2151608616 @default.
• W2110971717 cites W2151665495 @default.
• W2110971717 cites W2157460441 @default.
• W2110971717 cites W2157937554 @default.
• W2110971717 cites W2161881446 @default.
• W2110971717 cites W2162082188 @default.
• W2110971717 cites W2169760444 @default.
• W2110971717 cites W2175198496 @default.
• W2110971717 cites W2192080449 @default.
• W2110971717 cites W4232677247 @default.
• W2110971717 doi "https://doi.org/10.1091/mbc.e08-08-0809" @default.
• W2110971717 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2613099" @default.
• W2110971717 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18971375" @default.
• W2110971717 hasPublicationYear "2009" @default.
• W2110971717 type Work @default.
• W2110971717 sameAs 2110971717 @default.
• W2110971717 citedByCount "113" @default.
• W2110971717 countsByYear W21109717172012 @default.
• W2110971717 countsByYear W21109717172013 @default.
• W2110971717 countsByYear W21109717172014 @default.
• W2110971717 countsByYear W21109717172015 @default.
• W2110971717 countsByYear W21109717172016 @default.
• W2110971717 countsByYear W21109717172017 @default.
• W2110971717 countsByYear W21109717172018 @default.
• W2110971717 countsByYear W21109717172019 @default.
• W2110971717 countsByYear W21109717172020 @default.
• W2110971717 countsByYear W21109717172021 @default.
• W2110971717 countsByYear W21109717172022 @default.
• W2110971717 countsByYear W21109717172023 @default.
• W2110971717 crossrefType "journal-article" @default.
• W2110971717 hasAuthorship W2110971717A5002847510 @default.
• W2110971717 hasAuthorship W2110971717A5024328245 @default.
• W2110971717 hasAuthorship W2110971717A5030685089 @default.
• W2110971717 hasAuthorship W2110971717A5076058258 @default.
• W2110971717 hasBestOaLocation W21109717172 @default.
• W2110971717 hasConcept C125235067 @default.
• W2110971717 hasConcept C139447449 @default.
• W2110971717 hasConcept C1491633281 @default.

• next