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- W2110974311 endingPage "3434" @default.
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- W2110974311 abstract "ABSTRACT Liver mitochondria from the great green goby Zosterisessor ophiocephalus (Pallas) normally exhibit bioenergetic variables (membrane potential 165±7 mV; respiratory control ratio 6.6±0.4; ADP/O ratio 1.85±0.8; means ± s.e.m., N=6) and activities of physiological transport systems (phosphate/proton symporter, adenine nucleotide antiporter, Ca2+ electrophoretic uniporter) comparable with those of rat liver mitochondria. When incubated in the presence of Ca2+ and an inducer agent such as phosphate, these mitochondria undergo a complete collapse of membrane potential accompanied by a large-amplitude swelling of the matrix, influx of sucrose from the incubation medium, release of endogenous Mg2+ and K+ (approximately 90 % of the total) and of preaccumulated Ca2+ and oxidation of endogenous pyridine nucleotides. All these phenomena, which are completely eliminated by cyclosporin A and inhibited with different efficacies by Mg2+ and spermine, demonstrate that the induction of the permeability transition in this type of mitochondria has characteristics similar to those described in rat liver mitochondria. In contrast, the requirement for very high Ca2+ concentrations (greater than 100 μmol l−1 ) for the induction of the permeability transition represents a very important difference that distinguishes this phenomenon in fish and mammalian mitochondria." @default.
- W2110974311 created "2016-06-24" @default.
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- W2110974311 date "2000-11-15" @default.
- W2110974311 modified "2023-09-25" @default.
- W2110974311 title "The Membrane Permeability Transition in Liver Mitochondria of the Great Green Goby <i>Zosterisessor Ophiocephalus</i> (Pallas)" @default.
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- W2110974311 doi "https://doi.org/10.1242/jeb.203.22.3425" @default.
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