FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2110976726> ?p ?o ?g. }

• W2110976726 endingPage "401" @default.
• W2110976726 startingPage "395" @default.
• W2110976726 abstract "Many anti-neoplastic drugs are used globally during chemotherapy in the treatment of cancer. However, occupational exposure to anti-cancer drugs can represent a potential health risk to humans. Investigations on the genotoxicity of these drugs are inconsistent. Further, information on the genotoxic potential of anti-neoplastic drugs in medical personnel from India is not available. Hence, the aim of this study was to carry out genotoxicity monitoring of nurses from the oncology department of a hospital in South India, occupationally exposed to anti-neoplastic drugs under routine working conditions. The level of genome damage was determined in whole blood with the comet assay as well as micronucleus test (MNT) and in buccal epithelial cells with MNT alone of 60 nurses handling anti-neoplastic drugs and 60 referents matched for age and sex. Urinary cyclophosphamide (CP), used as a marker for drug absorption, was also measured in the urine of the nurses. The DNA damage observed in the lymphocytes of exposed nurses was significantly higher than the controls. Similarly, a significant increase in micronuclei (MN) frequency with peripheral blood lymphocytes and buccal cells was observed in the exposed nurses compared to controls (P < 0.05). Multiple regression analysis showed that occupational exposure and age had a significant effect on mean comet tail length as well as on frequency of MN. The mean value of CP in urine of the nurses handling anti-neoplastic drugs was (mean +/- standard deviation; 0.44 +/- 0.26 microg/ml). Our study has shown that increased genetic damage was evident in nurses due to occupational exposure to anti-neoplastics. This data corroborate the need to maintain safety measures to avoid exposure and the necessity of intervention in the case of exposure when using and handling anti-neoplastic drugs." @default.
• W2110976726 created "2016-06-24" @default.
• W2110976726 creator A5010346478 @default.
• W2110976726 creator A5014441418 @default.
• W2110976726 creator A5044103069 @default.
• W2110976726 creator A5066833632 @default.
• W2110976726 creator A5076103198 @default.
• W2110976726 creator A5077413265 @default.
• W2110976726 date "2007-08-20" @default.
• W2110976726 modified "2023-09-25" @default.
• W2110976726 title "Genotoxicity assessment in oncology nurses handling anti-neoplastic drugs" @default.
• W2110976726 cites W1965751277 @default.
• W2110976726 cites W1970010062 @default.
• W2110976726 cites W1977612105 @default.
• W2110976726 cites W1977949927 @default.
• W2110976726 cites W1985981279 @default.
• W2110976726 cites W1991940284 @default.
• W2110976726 cites W1992457242 @default.
• W2110976726 cites W1992974020 @default.
• W2110976726 cites W1996259885 @default.
• W2110976726 cites W1999239148 @default.
• W2110976726 cites W1999268311 @default.
• W2110976726 cites W2003702975 @default.
• W2110976726 cites W2012619545 @default.
• W2110976726 cites W2016511592 @default.
• W2110976726 cites W2018173246 @default.
• W2110976726 cites W2027666924 @default.
• W2110976726 cites W2031178218 @default.
• W2110976726 cites W2034637298 @default.
• W2110976726 cites W2039463832 @default.
• W2110976726 cites W2040436901 @default.
• W2110976726 cites W2049214724 @default.
• W2110976726 cites W2056204961 @default.
• W2110976726 cites W2060902588 @default.
• W2110976726 cites W2064563459 @default.
• W2110976726 cites W2065561800 @default.
• W2110976726 cites W2067446423 @default.
• W2110976726 cites W2068571459 @default.
• W2110976726 cites W2069083729 @default.
• W2110976726 cites W2081776090 @default.
• W2110976726 cites W2088650781 @default.
• W2110976726 cites W2092629964 @default.
• W2110976726 cites W2093327851 @default.
• W2110976726 cites W2113282769 @default.
• W2110976726 cites W2121732515 @default.
• W2110976726 cites W2122202506 @default.
• W2110976726 cites W2124487090 @default.
• W2110976726 cites W2124879569 @default.
• W2110976726 cites W2126673711 @default.
• W2110976726 cites W2129353790 @default.
• W2110976726 cites W2133112810 @default.
• W2110976726 cites W2140194403 @default.
• W2110976726 cites W2145556888 @default.
• W2110976726 cites W2155797417 @default.
• W2110976726 cites W2354680736 @default.
• W2110976726 cites W2377668192 @default.
• W2110976726 cites W592818598 @default.
• W2110976726 doi "https://doi.org/10.1093/mutage/gem032" @default.
• W2110976726 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17855733" @default.
• W2110976726 hasPublicationYear "2007" @default.
• W2110976726 type Work @default.
• W2110976726 sameAs 2110976726 @default.
• W2110976726 citedByCount "101" @default.
• W2110976726 countsByYear W21109767262012 @default.
• W2110976726 countsByYear W21109767262013 @default.
• W2110976726 countsByYear W21109767262014 @default.
• W2110976726 countsByYear W21109767262015 @default.
• W2110976726 countsByYear W21109767262016 @default.
• W2110976726 countsByYear W21109767262017 @default.
• W2110976726 countsByYear W21109767262018 @default.
• W2110976726 countsByYear W21109767262019 @default.
• W2110976726 countsByYear W21109767262020 @default.
• W2110976726 countsByYear W21109767262021 @default.
• W2110976726 countsByYear W21109767262022 @default.
• W2110976726 countsByYear W21109767262023 @default.
• W2110976726 crossrefType "journal-article" @default.
• W2110976726 hasAuthorship W2110976726A5010346478 @default.
• W2110976726 hasAuthorship W2110976726A5014441418 @default.
• W2110976726 hasAuthorship W2110976726A5044103069 @default.
• W2110976726 hasAuthorship W2110976726A5066833632 @default.
• W2110976726 hasAuthorship W2110976726A5076103198 @default.
• W2110976726 hasAuthorship W2110976726A5077413265 @default.
• W2110976726 hasBestOaLocation W21109767261 @default.
• W2110976726 hasConcept C121608353 @default.
• W2110976726 hasConcept C126322002 @default.
• W2110976726 hasConcept C143425029 @default.
• W2110976726 hasConcept C143998085 @default.
• W2110976726 hasConcept C167871757 @default.
• W2110976726 hasConcept C2776694085 @default.
• W2110976726 hasConcept C2776755627 @default.
• W2110976726 hasConcept C2778959862 @default.
• W2110976726 hasConcept C2780026642 @default.
• W2110976726 hasConcept C2780358455 @default.
• W2110976726 hasConcept C29730261 @default.
• W2110976726 hasConcept C33070731 @default.
• W2110976726 hasConcept C36681516 @default.
• W2110976726 hasConcept C42407357 @default.
• W2110976726 hasConcept C45080847 @default.

• next