FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2110992045> ?p ?o ?g. }

• W2110992045 endingPage "649" @default.
• W2110992045 startingPage "638" @default.
• W2110992045 abstract "Abstract We developed a murine model of CNS disease to obtain a better understanding of the pathogenesis of CNS involvement in pre-B-cell acute lymphoblastic leukemia (ALL). Semiquantitative proteomic discovery–based approaches identified unique expression of asparaginyl endopeptidase (AEP), intercellular adhesion molecule 1 (ICAM1), and ras-related C3 botulinum toxin substrate 2 (RAC2), among others, in an invasive pre-B-cell line that produced CNS leukemia in NOD-SCID mice. Targeting RAC2 significantly inhibited in vitro invasion and delayed disease onset in mice. Induced expression of RAC2 in cell lines with low/absent expression of AEP and ICAM1 did not result in an invasive phenotype or murine CNS disease. Flow cytometric analysis identified an enriched population of blast cells expressing ICAM1/lymphocyte function associated antigen-1 (LFA-1)/CD70 in the CD10+/CD19+ fraction of bone marrow aspirates obtained from relapsed compared with normal controls and those with primary disease. CD10+/CD19+ fractions obtained from relapsed patients also express RAC2 and give rise to CNS disease in mice. Our data suggest that combinations of processes are involved in the pathogenesis of CNS disease in pre-B-cell ALL, support a model in which CNS disease occurs as a result of external invasion, and suggest that targeting the processes of adhesion and invasion unique to pre-B cells may prevent recurrences within the CNS." @default.
• W2110992045 created "2016-06-24" @default.
• W2110992045 creator A5001854589 @default.
• W2110992045 creator A5013034924 @default.
• W2110992045 creator A5029130935 @default.
• W2110992045 creator A5029790333 @default.
• W2110992045 creator A5030480668 @default.
• W2110992045 creator A5031142194 @default.
• W2110992045 creator A5034221215 @default.
• W2110992045 creator A5039853077 @default.
• W2110992045 creator A5040163724 @default.
• W2110992045 creator A5048375196 @default.
• W2110992045 creator A5048763925 @default.
• W2110992045 creator A5050903950 @default.
• W2110992045 creator A5053476959 @default.
• W2110992045 creator A5068726950 @default.
• W2110992045 creator A5072265839 @default.
• W2110992045 creator A5074145853 @default.
• W2110992045 creator A5076360005 @default.
• W2110992045 creator A5078682100 @default.
• W2110992045 creator A5082997520 @default.
• W2110992045 creator A5090864400 @default.
• W2110992045 date "2011-07-21" @default.
• W2110992045 modified "2023-09-28" @default.
• W2110992045 title "RAC2, AEP, and ICAM1 expression are associated with CNS disease in a mouse model of pre-B childhood acute lymphoblastic leukemia" @default.
• W2110992045 cites W1534627398 @default.
• W2110992045 cites W1561793539 @default.
• W2110992045 cites W1634056846 @default.
• W2110992045 cites W1968211025 @default.
• W2110992045 cites W1968783143 @default.
• W2110992045 cites W1977380325 @default.
• W2110992045 cites W1978106259 @default.
• W2110992045 cites W1982627832 @default.
• W2110992045 cites W2001124847 @default.
• W2110992045 cites W2004314223 @default.
• W2110992045 cites W2005252392 @default.
• W2110992045 cites W2005312965 @default.
• W2110992045 cites W2010518012 @default.
• W2110992045 cites W2015179552 @default.
• W2110992045 cites W2022186451 @default.
• W2110992045 cites W2029098209 @default.
• W2110992045 cites W2035343180 @default.
• W2110992045 cites W2046409381 @default.
• W2110992045 cites W2052968739 @default.
• W2110992045 cites W2058761715 @default.
• W2110992045 cites W2060383229 @default.
• W2110992045 cites W2064771788 @default.
• W2110992045 cites W2065381832 @default.
• W2110992045 cites W2074143045 @default.
• W2110992045 cites W2076301301 @default.
• W2110992045 cites W2077037916 @default.
• W2110992045 cites W2086943873 @default.
• W2110992045 cites W2094577052 @default.
• W2110992045 cites W2095352560 @default.
• W2110992045 cites W2100512258 @default.
• W2110992045 cites W2103017472 @default.
• W2110992045 cites W2119806797 @default.
• W2110992045 cites W2120995880 @default.
• W2110992045 cites W2122925019 @default.
• W2110992045 cites W2132860363 @default.
• W2110992045 cites W2134266932 @default.
• W2110992045 cites W2142164842 @default.
• W2110992045 cites W2144656400 @default.
• W2110992045 cites W2148365034 @default.
• W2110992045 cites W2158285723 @default.
• W2110992045 cites W2160697532 @default.
• W2110992045 cites W2164396922 @default.
• W2110992045 cites W2167327186 @default.
• W2110992045 cites W2168628406 @default.
• W2110992045 cites W2171644620 @default.
• W2110992045 cites W2313910578 @default.
• W2110992045 cites W2793216206 @default.
• W2110992045 cites W4245415564 @default.
• W2110992045 doi "https://doi.org/10.1182/blood-2010-09-307330" @default.
• W2110992045 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21606482" @default.
• W2110992045 hasPublicationYear "2011" @default.
• W2110992045 type Work @default.
• W2110992045 sameAs 2110992045 @default.
• W2110992045 citedByCount "47" @default.
• W2110992045 countsByYear W21109920452012 @default.
• W2110992045 countsByYear W21109920452013 @default.
• W2110992045 countsByYear W21109920452014 @default.
• W2110992045 countsByYear W21109920452015 @default.
• W2110992045 countsByYear W21109920452016 @default.
• W2110992045 countsByYear W21109920452017 @default.
• W2110992045 countsByYear W21109920452018 @default.
• W2110992045 countsByYear W21109920452019 @default.
• W2110992045 countsByYear W21109920452020 @default.
• W2110992045 countsByYear W21109920452021 @default.
• W2110992045 countsByYear W21109920452022 @default.
• W2110992045 crossrefType "journal-article" @default.
• W2110992045 hasAuthorship W2110992045A5001854589 @default.
• W2110992045 hasAuthorship W2110992045A5013034924 @default.
• W2110992045 hasAuthorship W2110992045A5029130935 @default.
• W2110992045 hasAuthorship W2110992045A5029790333 @default.
• W2110992045 hasAuthorship W2110992045A5030480668 @default.
• W2110992045 hasAuthorship W2110992045A5031142194 @default.
• W2110992045 hasAuthorship W2110992045A5034221215 @default.

• next