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- W2110992433 endingPage "175" @default.
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- W2110992433 abstract "ADVANCED HEPATOCELLULAR CARCINOMA (HCC) IS A MALIGNANCY OF GLOBAL IMPORTANCE: it is the sixth most common cancer and the third most common cause of cancer-related mortality worldwide. Despite decades of efforts by many investigators, systemic chemotherapy or hormone therapy has failed to demonstrate improved survival in patients with HCC.. Ongoing studies are evaluating the efficacy and tolerability of combining Sorafenib with erlotinib and other targeted agents or chemotherapy.On the basis of placebo-controlled, randomized phase III trials, Sorafenib has shown improved survival benefits in advanced HCC and has set a new standard for future clinical trials. The successful clinical development of Sorafenib in HCC has ushered in the era of molecularly targeted agents in this disease, which is discussed in this educational review.Many molecularly targeted agents that inhibit angiogenesis, epidermal growth factor receptor, and mammalian target of rapamycin are at different stages of clinical development in advanced HCC. Future research should continue to unravel the mechanism of hepatocarcinogenesis and to identify key relevant molecular targets for therapeutic intervention. Identification and validation of potential surrogate and predictive biomarkers hold promise to individualize patients' treatment to maximize clinical benefit and minimize the toxicity and cost of targeted agents.Systemic therapy with various classes of agents, including hormone and cytotoxic agents, has provided no or marginal benefits. Improved understanding of the mechanism of hepatocarcinogenesis, coupled with the arrival of many newly developed molecularly targeted agents, has provided the unique opportunity to study some of these novel agents in advanced HCC.The demonstration of improved survival benefits by Sorafenib in advanced HCC has ushered in the era of molecular-targeted therapy in this disease, with many agents undergoing active clinical development." @default.
- W2110992433 created "2016-06-24" @default.
- W2110992433 creator A5005907814 @default.
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- W2110992433 creator A5059168649 @default.
- W2110992433 creator A5083433377 @default.
- W2110992433 date "2011-01-01" @default.
- W2110992433 modified "2023-09-23" @default.
- W2110992433 title "Systemic treatment and targeted therapy in patients with advanced hepatocellular carcinoma" @default.
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- W2110992433 doi "https://doi.org/10.4297/najms.2011.3167" @default.
- W2110992433 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3336907" @default.
- W2110992433 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22540086" @default.
- W2110992433 hasPublicationYear "2011" @default.
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