Matches in SemOpenAlex for { <https://semopenalex.org/work/W2111008033> ?p ?o ?g. }
- W2111008033 endingPage "583" @default.
- W2111008033 startingPage "574" @default.
- W2111008033 abstract "The report shows that CpG can exert additional adjuvant effects by inducing cells that are normally inferior antigen (Ag)-presenting cells to participate in immune induction by cross-priming. Macrophages (Mphi) exposed to protein Ag in the presence of bioactive CpG DNA released material that induced primary CD8(+) T cell responses in DC-naïve T cell cultures. This cross-priming event was accompanied by up-regulation of the stress protein response as well as inflammatory cytokine expression in treated Mphi. The material released was indicated to contain inducible heat shock protein-70 and epitope peptide, which in turn, were presented by dendritic cells (DCs) to responder T cells. Such an adjuvant effect by CpG may serve to salvage immunogenic material from otherwise inert depot cellular sites and additionally stimulate DCs to effectively cross-prime. The cross-priming, shown also to occur in vivo, may be particularly useful when Ag doses are low and have minimal opportunity for delivery to DCs for consequent direct priming." @default.
- W2111008033 created "2016-06-24" @default.
- W2111008033 creator A5013287504 @default.
- W2111008033 creator A5016830792 @default.
- W2111008033 creator A5081978553 @default.
- W2111008033 date "2003-05-01" @default.
- W2111008033 modified "2023-10-16" @default.
- W2111008033 title "Toll-like receptor ligand links innate and adaptive immune responses by the production of heat-shock proteins" @default.
- W2111008033 cites W1482760750 @default.
- W2111008033 cites W1484796735 @default.
- W2111008033 cites W1514540900 @default.
- W2111008033 cites W1524792851 @default.
- W2111008033 cites W1532906043 @default.
- W2111008033 cites W1538844879 @default.
- W2111008033 cites W1585007382 @default.
- W2111008033 cites W1589670817 @default.
- W2111008033 cites W1590733487 @default.
- W2111008033 cites W1601289536 @default.
- W2111008033 cites W1604363681 @default.
- W2111008033 cites W1608661399 @default.
- W2111008033 cites W1913450518 @default.
- W2111008033 cites W1935511302 @default.
- W2111008033 cites W1959677146 @default.
- W2111008033 cites W1968180425 @default.
- W2111008033 cites W1972171725 @default.
- W2111008033 cites W1977007393 @default.
- W2111008033 cites W1993677761 @default.
- W2111008033 cites W1995209114 @default.
- W2111008033 cites W1997988216 @default.
- W2111008033 cites W2001015172 @default.
- W2111008033 cites W2023772140 @default.
- W2111008033 cites W2024332323 @default.
- W2111008033 cites W2031557603 @default.
- W2111008033 cites W2033441782 @default.
- W2111008033 cites W2047110135 @default.
- W2111008033 cites W2047366876 @default.
- W2111008033 cites W2059884673 @default.
- W2111008033 cites W2074061180 @default.
- W2111008033 cites W2075097985 @default.
- W2111008033 cites W2075365494 @default.
- W2111008033 cites W2092128665 @default.
- W2111008033 cites W2094605832 @default.
- W2111008033 cites W2099186598 @default.
- W2111008033 cites W2100593890 @default.
- W2111008033 cites W2101189282 @default.
- W2111008033 cites W2105270641 @default.
- W2111008033 cites W2105371259 @default.
- W2111008033 cites W2105895969 @default.
- W2111008033 cites W2109352986 @default.
- W2111008033 cites W2115267868 @default.
- W2111008033 cites W2117761826 @default.
- W2111008033 cites W2118011548 @default.
- W2111008033 cites W2132568167 @default.
- W2111008033 cites W2155906523 @default.
- W2111008033 cites W2165645608 @default.
- W2111008033 cites W2170807014 @default.
- W2111008033 doi "https://doi.org/10.1189/jlb.0902470" @default.
- W2111008033 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12714571" @default.
- W2111008033 hasPublicationYear "2003" @default.
- W2111008033 type Work @default.
- W2111008033 sameAs 2111008033 @default.
- W2111008033 citedByCount "30" @default.
- W2111008033 countsByYear W21110080332012 @default.
- W2111008033 countsByYear W21110080332013 @default.
- W2111008033 countsByYear W21110080332015 @default.
- W2111008033 countsByYear W21110080332020 @default.
- W2111008033 countsByYear W21110080332022 @default.
- W2111008033 countsByYear W21110080332023 @default.
- W2111008033 crossrefType "journal-article" @default.
- W2111008033 hasAuthorship W2111008033A5013287504 @default.
- W2111008033 hasAuthorship W2111008033A5016830792 @default.
- W2111008033 hasAuthorship W2111008033A5081978553 @default.
- W2111008033 hasBestOaLocation W21110080331 @default.
- W2111008033 hasConcept C100701293 @default.
- W2111008033 hasConcept C104317684 @default.
- W2111008033 hasConcept C136449434 @default.
- W2111008033 hasConcept C150194340 @default.
- W2111008033 hasConcept C190727270 @default.
- W2111008033 hasConcept C193419808 @default.
- W2111008033 hasConcept C203014093 @default.
- W2111008033 hasConcept C205260736 @default.
- W2111008033 hasConcept C2776709828 @default.
- W2111008033 hasConcept C2777863537 @default.
- W2111008033 hasConcept C2778170410 @default.
- W2111008033 hasConcept C2778690821 @default.
- W2111008033 hasConcept C2779138994 @default.
- W2111008033 hasConcept C55493867 @default.
- W2111008033 hasConcept C59822182 @default.
- W2111008033 hasConcept C81444415 @default.
- W2111008033 hasConcept C86803240 @default.
- W2111008033 hasConcept C8891405 @default.
- W2111008033 hasConcept C95444343 @default.
- W2111008033 hasConceptScore W2111008033C100701293 @default.
- W2111008033 hasConceptScore W2111008033C104317684 @default.
- W2111008033 hasConceptScore W2111008033C136449434 @default.
- W2111008033 hasConceptScore W2111008033C150194340 @default.
- W2111008033 hasConceptScore W2111008033C190727270 @default.
- W2111008033 hasConceptScore W2111008033C193419808 @default.