FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2111011711> ?p ?o ?g. }

• W2111011711 endingPage "361" @default.
• W2111011711 startingPage "356" @default.
• W2111011711 abstract "Several lines of evidence point to a key role of the hippocampus in Autism Spectrum Disorders (ASD). Altered hippocampal volume and deficits in memory for person and emotion related stimuli have been reported, along with enhanced ability for declarative memories. Mouse models have demonstrated a critical role of the hippocampus in social memory dysfunction, associated with ASD, together with decreased synaptic plasticity. Chondroitin sulphate proteoglycans (CSPGs), a family of extracellular matrix molecules, represent a potential key link between neurodevelopment, synaptic plasticity, and immune system signaling. There is a lack of information regarding the molecular pathology of the hippocampus in ASD. We conducted RNAseq profiling on postmortem human brain samples containing the hippocampus from male children with ASD (n=7) and normal male children (3-14 yrs old), (n=6) from the NIH NeuroBioBank. Gene expression profiling analysis implicated molecular pathways involved in extracellular matrix organization, neurodevelopment, synaptic regulation, and immune system signaling. qRT-PCR and Western blotting were used to confirm several of the top markers identified. The CSPG protein BCAN was examined with multiplex immunofluorescence to analyze cell-type specific expression of BCAN and astrocyte morphology. We observed decreased expression of synaptic proteins PSD95 (p<0.02) and SYN1 (p<0.02), increased expression of the extracellular matrix (ECM) protease MMP9 (p<0.03), and decreased expression of MEF2C (p<0.03). We also observed increased BCAN expression with astrocytes in children with ASD, together with altered astrocyte morphology. Our results point to alterations in immune system signaling, glia cell differentiation, and synaptic signaling in the hippocampus of children with ASD, together with alterations in extracellular matrix molecules. Furthermore, our results demonstrate altered expression of genes implicated in genetic studies of ASD including SYN1 and MEF2C." @default.
• W2111011711 created "2016-06-24" @default.
• W2111011711 creator A5017435787 @default.
• W2111011711 creator A5017491554 @default.
• W2111011711 creator A5034296000 @default.
• W2111011711 creator A5040449943 @default.
• W2111011711 creator A5058842094 @default.
• W2111011711 creator A5063684198 @default.
• W2111011711 creator A5079094423 @default.
• W2111011711 creator A5091153597 @default.
• W2111011711 date "1998-04-01" @default.
• W2111011711 modified "2023-10-06" @default.
• W2111011711 title "Circumstances and causes of out-of-hospital cardiac arrest in sudden death survivors" @default.
• W2111011711 cites W1965048399 @default.
• W2111011711 cites W1965718784 @default.
• W2111011711 cites W1970445644 @default.
• W2111011711 cites W1980715583 @default.
• W2111011711 cites W1981144345 @default.
• W2111011711 cites W1992765958 @default.
• W2111011711 cites W1998609175 @default.
• W2111011711 cites W2000898801 @default.
• W2111011711 cites W2018229651 @default.
• W2111011711 cites W2036032848 @default.
• W2111011711 cites W2039937506 @default.
• W2111011711 cites W2042896781 @default.
• W2111011711 cites W2064654005 @default.
• W2111011711 cites W2071743537 @default.
• W2111011711 cites W2086465394 @default.
• W2111011711 cites W2092357214 @default.
• W2111011711 cites W2109740469 @default.
• W2111011711 cites W2319931350 @default.
• W2111011711 cites W2326800386 @default.
• W2111011711 doi "https://doi.org/10.1136/hrt.79.4.356" @default.
• W2111011711 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1728666" @default.
• W2111011711 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9616342" @default.
• W2111011711 hasPublicationYear "1998" @default.
• W2111011711 type Work @default.
• W2111011711 sameAs 2111011711 @default.
• W2111011711 citedByCount "74" @default.
• W2111011711 countsByYear W21110117112012 @default.
• W2111011711 countsByYear W21110117112013 @default.
• W2111011711 countsByYear W21110117112014 @default.
• W2111011711 countsByYear W21110117112015 @default.
• W2111011711 countsByYear W21110117112016 @default.
• W2111011711 countsByYear W21110117112017 @default.
• W2111011711 countsByYear W21110117112018 @default.
• W2111011711 countsByYear W21110117112019 @default.
• W2111011711 countsByYear W21110117112020 @default.
• W2111011711 countsByYear W21110117112021 @default.
• W2111011711 countsByYear W21110117112022 @default.
• W2111011711 countsByYear W21110117112023 @default.
• W2111011711 crossrefType "journal-article" @default.
• W2111011711 hasAuthorship W2111011711A5017435787 @default.
• W2111011711 hasAuthorship W2111011711A5017491554 @default.
• W2111011711 hasAuthorship W2111011711A5034296000 @default.
• W2111011711 hasAuthorship W2111011711A5040449943 @default.
• W2111011711 hasAuthorship W2111011711A5058842094 @default.
• W2111011711 hasAuthorship W2111011711A5063684198 @default.
• W2111011711 hasAuthorship W2111011711A5079094423 @default.
• W2111011711 hasAuthorship W2111011711A5091153597 @default.
• W2111011711 hasBestOaLocation W21110117111 @default.
• W2111011711 hasConcept C126322002 @default.
• W2111011711 hasConcept C129987498 @default.
• W2111011711 hasConcept C148762608 @default.
• W2111011711 hasConcept C169760540 @default.
• W2111011711 hasConcept C170493617 @default.
• W2111011711 hasConcept C203014093 @default.
• W2111011711 hasConcept C204232928 @default.
• W2111011711 hasConcept C2777209535 @default.
• W2111011711 hasConcept C2777542381 @default.
• W2111011711 hasConcept C2781161787 @default.
• W2111011711 hasConcept C47611674 @default.
• W2111011711 hasConcept C529278444 @default.
• W2111011711 hasConcept C71924100 @default.
• W2111011711 hasConcept C86803240 @default.
• W2111011711 hasConcept C95444343 @default.
• W2111011711 hasConcept C98229152 @default.
• W2111011711 hasConceptScore W2111011711C126322002 @default.
• W2111011711 hasConceptScore W2111011711C129987498 @default.
• W2111011711 hasConceptScore W2111011711C148762608 @default.
• W2111011711 hasConceptScore W2111011711C169760540 @default.
• W2111011711 hasConceptScore W2111011711C170493617 @default.
• W2111011711 hasConceptScore W2111011711C203014093 @default.
• W2111011711 hasConceptScore W2111011711C204232928 @default.
• W2111011711 hasConceptScore W2111011711C2777209535 @default.
• W2111011711 hasConceptScore W2111011711C2777542381 @default.
• W2111011711 hasConceptScore W2111011711C2781161787 @default.
• W2111011711 hasConceptScore W2111011711C47611674 @default.
• W2111011711 hasConceptScore W2111011711C529278444 @default.
• W2111011711 hasConceptScore W2111011711C71924100 @default.
• W2111011711 hasConceptScore W2111011711C86803240 @default.
• W2111011711 hasConceptScore W2111011711C95444343 @default.
• W2111011711 hasConceptScore W2111011711C98229152 @default.
• W2111011711 hasIssue "4" @default.
• W2111011711 hasLocation W21110117111 @default.
• W2111011711 hasLocation W21110117112 @default.
• W2111011711 hasLocation W21110117113 @default.
• W2111011711 hasLocation W21110117114 @default.

• next