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- W2111012912 abstract "Feasibility of soft tissue emulsification using shock wave heating and millisecond boiling induced by high intensity focused ultrasound was demonstrated recently. However, the mechanism by which the bubbles emulsify tissue is not well understood. High-speed photography of such exposures in transparent gel phantoms shows a milimeter-sized boiling bubble, and histological analysis in tissue samples reveals sub-micron-sized fragments. Here, a novel mechanism of tissue emulsification by the formation of a miniature acoustic fountain within the boiling bubble is tested experimentally using a 2 MHz transducer generating up to 70 MPa positive and 15 MPa negative peak pressures at the focus. The focus was positioned at or 1–2 mm off the plane interface between air and various materials including degassed water, transparent gel, thin sliced muscle tissue phantom, and ex-vivo tissue. Pulsing schemes with duty factors 0.001–0.1, and pulse durations 0.05–500 ms were used. Violent removal of micron-sized fragments and substantial displacement of the phantom surface were observed through high-speed filming. At the end of each exposure, the resulting erosion of the phantom surface and subsurface area was photographed and related to the exposure parameters. Work supported by NIH (DK43881, DK070618, EB007643, and DK007742) and NSBRI through NASA NCC 9-58." @default.
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- W2111012912 date "2011-04-01" @default.
- W2111012912 modified "2023-09-23" @default.
- W2111012912 title "Miniature acoustic fountain mechanism for tissue emulsification during millisecond boiling in high intensity focused ultrasound fields." @default.
- W2111012912 doi "https://doi.org/10.1121/1.3588151" @default.
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