Matches in SemOpenAlex for { <https://semopenalex.org/work/W2111018768> ?p ?o ?g. }
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- W2111018768 abstract "While the functions of hypoxia-inducible factor 1α (HIF1α)/aryl hydrocarbon receptor nuclear translocator (ARNT) and HIF2α/ARNT (HIF2) proteins in activating hypoxia-inducible genes are well established, the role of other transcription factors in the hypoxic transcriptional response is less clear. We report here for the first time that the basic helix-loop-helix-leucine-zip transcription factor upstream stimulatory factor 2 (USF2) is required for the hypoxic transcriptional response, specifically, for hypoxic activation of HIF2 target genes. We show that inhibiting USF2 activity greatly reduces hypoxic induction of HIF2 target genes in cell lines that have USF2 activity, while inducing USF2 activity in cells lacking USF2 activity restores hypoxic induction of HIF2 target genes. Mechanistically, USF2 activates HIF2 target genes by binding to HIF2 target gene promoters, interacting with HIF2α protein, and recruiting coactivators CBP and p300 to form enhanceosome complexes that contain HIF2α, USF2, CBP, p300, and RNA polymerase II on HIF2 target gene promoters. Functionally, the effect of USF2 knockdown on proliferation, motility, and clonogenic survival of HIF2-dependent tumor cells in vitro is phenocopied by HIF2α knockdown, indicating that USF2 works with HIF2 to activate HIF2 target genes and to drive HIF2-depedent tumorigenesis." @default.
- W2111018768 created "2016-06-24" @default.
- W2111018768 creator A5029372068 @default.
- W2111018768 creator A5048656863 @default.
- W2111018768 creator A5065768611 @default.
- W2111018768 creator A5075113133 @default.
- W2111018768 date "2012-11-01" @default.
- W2111018768 modified "2023-10-14" @default.
- W2111018768 title "Upstream Stimulatory Factor 2 and Hypoxia-Inducible Factor 2<i>α</i> (HIF2<i>α</i>) Cooperatively Activate HIF2 Target Genes during Hypoxia" @default.
- W2111018768 cites W1230664046 @default.
- W2111018768 cites W1522251904 @default.
- W2111018768 cites W1525334014 @default.
- W2111018768 cites W1528664004 @default.
- W2111018768 cites W1613477746 @default.
- W2111018768 cites W181093158 @default.
- W2111018768 cites W1966548405 @default.
- W2111018768 cites W1970951301 @default.
- W2111018768 cites W1975545468 @default.
- W2111018768 cites W1977128725 @default.
- W2111018768 cites W1978197555 @default.
- W2111018768 cites W1980475208 @default.
- W2111018768 cites W1982685209 @default.
- W2111018768 cites W1984214335 @default.
- W2111018768 cites W1986674952 @default.
- W2111018768 cites W1989375763 @default.
- W2111018768 cites W1990607537 @default.
- W2111018768 cites W1991185690 @default.
- W2111018768 cites W1993325199 @default.
- W2111018768 cites W1993487480 @default.
- W2111018768 cites W1997767982 @default.
- W2111018768 cites W1998664010 @default.
- W2111018768 cites W1999276461 @default.
- W2111018768 cites W2000576419 @default.
- W2111018768 cites W2001631143 @default.
- W2111018768 cites W2003114121 @default.
- W2111018768 cites W2006833515 @default.
- W2111018768 cites W2009522838 @default.
- W2111018768 cites W2010356452 @default.
- W2111018768 cites W2015145164 @default.
- W2111018768 cites W2017868517 @default.
- W2111018768 cites W2020940277 @default.
- W2111018768 cites W2021656373 @default.
- W2111018768 cites W2021914074 @default.
- W2111018768 cites W2022307144 @default.
- W2111018768 cites W2022922534 @default.
- W2111018768 cites W2025308945 @default.
- W2111018768 cites W2025828996 @default.
- W2111018768 cites W2027121745 @default.
- W2111018768 cites W2039579801 @default.
- W2111018768 cites W2042945618 @default.
- W2111018768 cites W2044257922 @default.
- W2111018768 cites W2044298789 @default.
- W2111018768 cites W2048555922 @default.
- W2111018768 cites W2048738064 @default.
- W2111018768 cites W2052410726 @default.
- W2111018768 cites W2052612011 @default.
- W2111018768 cites W2052694816 @default.
- W2111018768 cites W2055086957 @default.
- W2111018768 cites W2055453684 @default.
- W2111018768 cites W2058412949 @default.
- W2111018768 cites W2060525294 @default.
- W2111018768 cites W2062875409 @default.
- W2111018768 cites W2063076489 @default.
- W2111018768 cites W2065152225 @default.
- W2111018768 cites W2067173241 @default.
- W2111018768 cites W2067945873 @default.
- W2111018768 cites W2068555309 @default.
- W2111018768 cites W2069647037 @default.
- W2111018768 cites W2080299092 @default.
- W2111018768 cites W2081329333 @default.
- W2111018768 cites W2081635255 @default.
- W2111018768 cites W2082493554 @default.
- W2111018768 cites W2082584138 @default.
- W2111018768 cites W2082639976 @default.
- W2111018768 cites W2083411239 @default.
- W2111018768 cites W2087377825 @default.
- W2111018768 cites W2088577765 @default.
- W2111018768 cites W2089164365 @default.
- W2111018768 cites W2089200494 @default.
- W2111018768 cites W2089288678 @default.
- W2111018768 cites W2090165219 @default.
- W2111018768 cites W2094242056 @default.
- W2111018768 cites W2095160894 @default.
- W2111018768 cites W2098041070 @default.
- W2111018768 cites W2098427962 @default.
- W2111018768 cites W2101084498 @default.
- W2111018768 cites W2102179727 @default.
- W2111018768 cites W2102254046 @default.
- W2111018768 cites W2108186386 @default.
- W2111018768 cites W2110085982 @default.
- W2111018768 cites W2110319156 @default.
- W2111018768 cites W2111983416 @default.
- W2111018768 cites W2116763746 @default.
- W2111018768 cites W2117779825 @default.
- W2111018768 cites W2119869309 @default.
- W2111018768 cites W2122535638 @default.
- W2111018768 cites W2124287509 @default.
- W2111018768 cites W2124650807 @default.