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• W2111021188 abstract "BackgroundFew studies have addressed primary human immunodeficiency virus (HIV) type 1 infection in sub-Saharan Africa, where the epidemic is of a predominantly heterosexual character and is caused by different subtypes. The present study examines the dynamics of viral replication in subjects infected with various HIV-1 subtypes MethodsSeven hundred fifty-two HIV-negative Senegalese women at high risk for infection were monitored every 3 months for acute/early HIV infection; 26 infections were identified (23 HIV-1 and 3 HIV-2), with an HIV-1 incidence rate of 3.23 cases/person-years observation. Multiple viral-load measurements were taken for all seroconverters ResultsThe mean ± standard deviation viral load for all subjects during the early stage of infection was 4.13±0.66 log10 copies/mL, with an overall decrease of 0.22 log10 copies/mL after the early stage; the viral set point was reached after 12 months of infection. Most subjects had relatively low viral loads during the early stage of infection. HIV-1 CRF02_AG–infected women had a significantly higher mean viral load during the early stage of infection (mean ± SD, 4.45±0.60 log10 copies/mL) than did non–HIV-1 CRF02_AG–infected women (mean ± SD, 3.78±0.46 log10 copies/mL) (P=.008). None of the subjects reported symptoms consistent with primary HIV-1 infection ConclusionOur findings in Senegalese women differ from what have been described for primary HIV-1 infection. Further investigations of primary infections with non-B subtypes are warranted, to better characterize their differences with primary infections with subtype B" @default.
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• W2111021188 date "2005-05-01" @default.
• W2111021188 modified "2023-10-18" @default.
• W2111021188 title "Viral Dynamics of Primary HIV‐1 Infection in Senegal, West Africa" @default.
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• W2111021188 doi "https://doi.org/10.1086/429409" @default.
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