FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2111036001> ?p ?o ?g. }

• W2111036001 endingPage "151" @default.
• W2111036001 startingPage "149" @default.
• W2111036001 abstract "The protein tyrosine kinases (PTKs) are a group of enzyme proteins that can phosphorylate substrate protein tyrosine residues, and are involved in many signal transduction pathways. They also play an important role in the control of cell differentiation, proliferation, and spreading. A recent study has found that Syk, as a tumor suppressor of PTKs, is closely related to tumor invasion and metastasis [1]. Syk has been also showed to have potential inhibitory effect in breast, gastric, and pancreatic cancers [2–4]. Sung et al. [5] found that in the mouse mammary gland, loss of one Syk allele profoundly increased proliferation, ductal branching, and invasion of epithelial cells through the mammary fat pad during puberty, and that mammary carcinoma developed after 1 year. An increasing number of clinical studies have revealed a correlation between reduced Syk expression and increased risk of metastasis formation, and Syk is assigned as a potential new prognostic marker in different tumor types [6]. In this study, we examined the expression of Syk in non-small-cell lung cancer (NSCLC) and analyzed its association with the prognosis. The study approved by the Ethics Committee of the Second Hospital of Shandong University included 70 patients (54 males, 16 females; median age of 61 years, ranged from 41 to 76 years) with NSCLC that were diagnosed in the Department of Thoracic Surgery, the Second Hospital of Shandong University. In 70 cases, 28 were diagnosed as adenocarcinoma, 36 squamous-cell carcinoma and 6 large-cell carcinoma. According to Primary Lung Cancer Diagnostic and Treatment Practices (2001), 13 cases belonged to stage I, 33 stage II, 19 stage III, and 5 stage IV. None of the patients received radiation or chemotherapy before surgery. All patients were followed up from January 2007 to December 2010. Tumor tissues were taken from primary tumor area, avoiding necrosis and inflammatory areas. Adjacent tissues were from 2 cm next to the tumor material, and normal lung tissues from 5 cm next to tumor margin. Pathological examination showed no carcinoma cells. Syk expression was immunohistochemically examined using mouse anti-human Syk monoclonal antibody (NeoMarkerS, Fremont, USA) under a light microscope. Three fields of cells were counted, respectively at 400 magnification to determine whether the cells were positive for Syk, and the percentage of stained cells was averaged. Specimens were regarded as Syk negative if ,5% of the cells were stained, 5%–25% as ‘þ’, 25%– 50% as ‘þþ’, and .50% as ‘þþþ’ according to many previous reports [7,8]. The results showed that brown particles could be seen in the cytoplasm in Syk-positive cells under a light microscope (Fig. 1). Syk expression rates were 5.7%, 95.7%, and 100% in tumor, adjacent lung cells, and normal lung cells, respectively. The positive rates were 5.6% in squamous-cell carcinoma, 3.6% in adenocarcinoma, and 16.7% in largecell carcinoma (P 1⁄4 0.394). Syk expression rate in NSCLC tumor cells was significantly lower compared with those in normal lung tissue and adjacent lung tissue (P, 0.05), while there was no difference between adjacent lung tissue and normal lung tissue. These results are similar to previous reports about Syk expression in other types of malignant tumors [4]. However, unlike those reported in previous studies, the Syk expression rates among patients of different pathologic types, differentiation, and clinical stages did not reveal any statistically significant differences. A previous study showed [6] that Syk expression was negatively correlated with differentiation and clinical stages of malignant tumors such as pancreatic cancer, esophageal squamous cell carcinoma, and endometrial cancer. We also noticed that the positive rate of Syk expression in our study was much lower than those reported in previous literatures. This may be explained by the following factors: very low expression of Syk in NSCLC, small sample size, and experimental techniques. Large sample volume and other experimental methods are needed for further study. Other associations between Syk expression and lymph node metastasis, tumor size, and tumor node metastasis have been reported [9], and the results also need further validation. In our study, 47 patients survived .3 years, and Syk expression in this group (8.57%) was higher than that with Acta Biochim Biophys Sin 2013, 45: 149–151 | a The Author 2012. Published by ABBS Editorial Office in association with Oxford University Press on behalf of the Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences. DOI: 10.1093/abbs/gms102. Advance Access Publication 2 December 2012" @default.
• W2111036001 created "2016-06-24" @default.
• W2111036001 creator A5009857080 @default.
• W2111036001 creator A5021310386 @default.
• W2111036001 creator A5022654613 @default.
• W2111036001 creator A5049774694 @default.
• W2111036001 creator A5051939570 @default.
• W2111036001 creator A5083354127 @default.
• W2111036001 date "2013-02-01" @default.
• W2111036001 modified "2023-10-10" @default.
• W2111036001 title "Syk is low-expressed in non-small-cell lung cancer and inversely correlates with patient's survival" @default.
• W2111036001 cites W1995174138 @default.
• W2111036001 cites W2019771009 @default.
• W2111036001 cites W2020975490 @default.
• W2111036001 cites W2029806310 @default.
• W2111036001 cites W2038213084 @default.
• W2111036001 cites W2066639629 @default.
• W2111036001 cites W2069232697 @default.
• W2111036001 cites W2069301170 @default.
• W2111036001 cites W2083955716 @default.
• W2111036001 cites W2103018333 @default.
• W2111036001 cites W2135744522 @default.
• W2111036001 cites W2164971856 @default.
• W2111036001 doi "https://doi.org/10.1093/abbs/gms102" @default.
• W2111036001 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23204309" @default.
• W2111036001 hasPublicationYear "2013" @default.
• W2111036001 type Work @default.
• W2111036001 sameAs 2111036001 @default.
• W2111036001 citedByCount "9" @default.
• W2111036001 countsByYear W21110360012013 @default.
• W2111036001 countsByYear W21110360012015 @default.
• W2111036001 countsByYear W21110360012016 @default.
• W2111036001 countsByYear W21110360012018 @default.
• W2111036001 countsByYear W21110360012019 @default.
• W2111036001 countsByYear W21110360012020 @default.
• W2111036001 countsByYear W21110360012023 @default.
• W2111036001 crossrefType "journal-article" @default.
• W2111036001 hasAuthorship W2111036001A5009857080 @default.
• W2111036001 hasAuthorship W2111036001A5021310386 @default.
• W2111036001 hasAuthorship W2111036001A5022654613 @default.
• W2111036001 hasAuthorship W2111036001A5049774694 @default.
• W2111036001 hasAuthorship W2111036001A5051939570 @default.
• W2111036001 hasAuthorship W2111036001A5083354127 @default.
• W2111036001 hasConcept C126322002 @default.
• W2111036001 hasConcept C143998085 @default.
• W2111036001 hasConcept C170493617 @default.
• W2111036001 hasConcept C2776256026 @default.
• W2111036001 hasConcept C2777714996 @default.
• W2111036001 hasConcept C35174551 @default.
• W2111036001 hasConcept C42362537 @default.
• W2111036001 hasConcept C502942594 @default.
• W2111036001 hasConcept C71924100 @default.
• W2111036001 hasConcept C86803240 @default.
• W2111036001 hasConceptScore W2111036001C126322002 @default.
• W2111036001 hasConceptScore W2111036001C143998085 @default.
• W2111036001 hasConceptScore W2111036001C170493617 @default.
• W2111036001 hasConceptScore W2111036001C2776256026 @default.
• W2111036001 hasConceptScore W2111036001C2777714996 @default.
• W2111036001 hasConceptScore W2111036001C35174551 @default.
• W2111036001 hasConceptScore W2111036001C42362537 @default.
• W2111036001 hasConceptScore W2111036001C502942594 @default.
• W2111036001 hasConceptScore W2111036001C71924100 @default.
• W2111036001 hasConceptScore W2111036001C86803240 @default.
• W2111036001 hasIssue "2" @default.
• W2111036001 hasLocation W21110360011 @default.
• W2111036001 hasLocation W21110360012 @default.
• W2111036001 hasOpenAccess W2111036001 @default.
• W2111036001 hasPrimaryLocation W21110360011 @default.
• W2111036001 hasRelatedWork W1967103478 @default.
• W2111036001 hasRelatedWork W1999841187 @default.
• W2111036001 hasRelatedWork W2032912323 @default.
• W2111036001 hasRelatedWork W2372561159 @default.
• W2111036001 hasRelatedWork W2375344515 @default.
• W2111036001 hasRelatedWork W2390152934 @default.
• W2111036001 hasRelatedWork W2460278033 @default.
• W2111036001 hasRelatedWork W2495422952 @default.
• W2111036001 hasRelatedWork W2996445182 @default.
• W2111036001 hasRelatedWork W3003862081 @default.
• W2111036001 hasVolume "45" @default.
• W2111036001 isParatext "false" @default.
• W2111036001 isRetracted "false" @default.
• W2111036001 magId "2111036001" @default.
• W2111036001 workType "article" @default.