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- W2111040978 abstract "Background. Chronic liver disease has been shown to causebone osteometabolic disease giving rise to osteoporosis andosteomalacia.Aim of this study was to evaluate bone mineral density (BMD)and bone metabolism markers in a selected series of male patientsliving in the same geographical area of Southern Italy,affected only by viral, non-advanced chronic liver disease, ascompared to a randomly selected control group from thesame geographical area.Patients ans Methods. Twentyfive male patients affected bybiopsy-proven chronic hepatitis or liver cirrhosis only inChild’s A class, virus-related, were selected in a one year period.Thirthy healthy male volunteers, living in the same geographicalarea, age, and BMI-matched, were examined as controlgroup.Bone mineral density (BMD) was measured at lumbar spine(L1-L4) and at proximal femur of non dominant leg by Dual-EnergyX-ray Absorptiometry (DEXA) using a Hologic QDR 1000densitometer. Biochemical tests of liver function and bonemetabolism in patients and controls were carried out after anovernight fast.R e s u l t s . BMD was reduced in 16 (64%) out of 25 patients: 5patients (20%) could be classified as osteoporotic and 11 patients(44%) osteopenic on the basis of at least one measurement.Mean BMD values for lumbar spine and femoral neckwere significantly decreased in patients in comparison to thecontrols. Using multiple linear regression analysis, no correlationwas found between BMD and the biochemical and functionalvariables studied.Our patients did not show any difference, as compared to controls,in bone remodelling markers as serum PTH, 25-OHD,calcium and sexual hormones, as well as urinary hydroxyproline.Conclusions. Our data, obtained on the basis of severe inclusioncriteria, suggest that liver disease “per se” indipendentlyon its severity and lasting, can reduce the bone mass. Thereforemore attention has to be paid to bone metabolism in liverpatients." @default.
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- W2111040978 date "2005-01-01" @default.
- W2111040978 modified "2023-09-24" @default.
- W2111040978 title "Osteoporosis in men: a study in patients affected by chronic non-advanced liver disease" @default.
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