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• W2111058831 abstract "In recent times, the perception of functional gastrointestinal disorders such as irritable bowel syndrome (IBS) has shifted fundamentally. Such disorders are now thought of as serious diseases characterized by perturbations in the neuronal regulation of gastrointestinal function. The concept of visceral hypersensitivity, the characterization of neuronal networks in the 'brain-gut axis' and the identification of several novel 5-HT-mediated mechanisms have contributed to this shift. Here, we review how some of the more promising of these new mechanisms (e.g. those involving 5-HT transporters and the 5-HT(2B), 5-HT(7) and putative 5-HT(1p) receptors) might lead to a range of second-generation therapies that could revolutionize the treatment of functional gastrointestinal disorders, particularly IBS." @default.
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• W2111058831 date "2007-01-01" @default.
• W2111058831 modified "2023-10-14" @default.
• W2111058831 title "5-HT in the enteric nervous system: gut function and neuropharmacology" @default.
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• W2111058831 doi "https://doi.org/10.1016/j.tins.2006.11.002" @default.
• W2111058831 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17126921" @default.
• W2111058831 hasPublicationYear "2007" @default.
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