FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2111062014> ?p ?o ?g. }

• W2111062014 endingPage "604" @default.
• W2111062014 startingPage "599" @default.
• W2111062014 abstract "The tumour suppressor gene PTEN/MMAC1/TEP1 encodes a dual-specificity phosphatase that recognizes phosphatidylinositol-3,4,5-triphosphate and protein substrates. We have shown previously that over-expression of PTEN in a tetracycline-controlled inducible system blocks cell cycle progression and induces apoptosis in MCF-7 breast cancer cells. Here, we demonstrate that over-expression of wild-type PTEN leads to the suppression of cell growth through the blockade of cell cycle progression, an increase in the abundance of p27, a decrease in the protein levels of cyclin D1 and the inhibition of Akt phosphorylation. In contrast, expression of the phosphatase-dead mutant, C124S, promotes cell growth and has the opposite effect on the abundance of p27, cyclin D1 levels and the phosphorylation of Akt. The G129E mutant, which does not have lipid phosphatase activity but retains protein phosphatase activity, behaves like C124S except that the former causes decreases in cyclin D1 levels similar to wild-type PTEN. Therefore, PTEN exerts its growth suppression through lipid phosphatase-dependent and independent activities and most likely, via the coordinate effect of both protein phosphatase and lipid phosphatase activities. Addition of either estrogen or insulin abrogates PTEN-mediated up-regulation of p27 and partially blocks PTEN-mediated growth suppression, whereas the combination of estrogen and insulin eliminates the alterations of p27 and cyclin D1 and completely blocks PTEN-mediated growth suppression. Our findings demonstrate that PTEN blocks cell cycle progression differentially through down-regulating the positive cell cycle regulator, cyclin D1, by its protein phosphatase activity, and up-regulating the negative cell cycle regulator, p27, by its lipid phosphatase activity." @default.
• W2111062014 created "2016-06-24" @default.
• W2111062014 creator A5028360650 @default.
• W2111062014 creator A5038322204 @default.
• W2111062014 creator A5042443419 @default.
• W2111062014 date "2001-03-01" @default.
• W2111062014 modified "2023-10-01" @default.
• W2111062014 title "PTEN coordinates G1 arrest by down-regulating cyclin D1 via its protein phosphatase activity and up-regulating p27 via its lipid phosphatase activity in a breast cancer model" @default.
• W2111062014 cites W1551696649 @default.
• W2111062014 cites W1558515869 @default.
• W2111062014 cites W1561313993 @default.
• W2111062014 cites W1589359922 @default.
• W2111062014 cites W1637251086 @default.
• W2111062014 cites W1673025041 @default.
• W2111062014 cites W1675773434 @default.
• W2111062014 cites W1935114338 @default.
• W2111062014 cites W1939083266 @default.
• W2111062014 cites W1968091333 @default.
• W2111062014 cites W1974738516 @default.
• W2111062014 cites W1992104313 @default.
• W2111062014 cites W1998038367 @default.
• W2111062014 cites W2000780971 @default.
• W2111062014 cites W2001413092 @default.
• W2111062014 cites W2004123711 @default.
• W2111062014 cites W2006844704 @default.
• W2111062014 cites W2019017173 @default.
• W2111062014 cites W2024220711 @default.
• W2111062014 cites W2033783187 @default.
• W2111062014 cites W2044467623 @default.
• W2111062014 cites W2046867705 @default.
• W2111062014 cites W2062860025 @default.
• W2111062014 cites W2065982982 @default.
• W2111062014 cites W2068345721 @default.
• W2111062014 cites W2068427129 @default.
• W2111062014 cites W2076457965 @default.
• W2111062014 cites W2113255254 @default.
• W2111062014 cites W2118182234 @default.
• W2111062014 cites W2122230708 @default.
• W2111062014 cites W2127219942 @default.
• W2111062014 cites W2130661390 @default.
• W2111062014 cites W2150233389 @default.
• W2111062014 cites W2152988906 @default.
• W2111062014 cites W2157023326 @default.
• W2111062014 cites W2161810908 @default.
• W2111062014 cites W2316848840 @default.
• W2111062014 doi "https://doi.org/10.1093/hmg/10.6.599" @default.
• W2111062014 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11230179" @default.
• W2111062014 hasPublicationYear "2001" @default.
• W2111062014 type Work @default.
• W2111062014 sameAs 2111062014 @default.
• W2111062014 citedByCount "239" @default.
• W2111062014 countsByYear W21110620142012 @default.
• W2111062014 countsByYear W21110620142013 @default.
• W2111062014 countsByYear W21110620142014 @default.
• W2111062014 countsByYear W21110620142015 @default.
• W2111062014 countsByYear W21110620142016 @default.
• W2111062014 countsByYear W21110620142017 @default.
• W2111062014 countsByYear W21110620142018 @default.
• W2111062014 countsByYear W21110620142019 @default.
• W2111062014 countsByYear W21110620142020 @default.
• W2111062014 countsByYear W21110620142021 @default.
• W2111062014 countsByYear W21110620142022 @default.
• W2111062014 countsByYear W21110620142023 @default.
• W2111062014 crossrefType "journal-article" @default.
• W2111062014 hasAuthorship W2111062014A5028360650 @default.
• W2111062014 hasAuthorship W2111062014A5038322204 @default.
• W2111062014 hasAuthorship W2111062014A5042443419 @default.
• W2111062014 hasBestOaLocation W21110620141 @default.
• W2111062014 hasConcept C11882975 @default.
• W2111062014 hasConcept C11960822 @default.
• W2111062014 hasConcept C1491633281 @default.
• W2111062014 hasConcept C16438837 @default.
• W2111062014 hasConcept C178666793 @default.
• W2111062014 hasConcept C199835354 @default.
• W2111062014 hasConcept C2777609662 @default.
• W2111062014 hasConcept C29537977 @default.
• W2111062014 hasConcept C502942594 @default.
• W2111062014 hasConcept C55493867 @default.
• W2111062014 hasConcept C62112901 @default.
• W2111062014 hasConcept C62478195 @default.
• W2111062014 hasConcept C75217442 @default.
• W2111062014 hasConcept C86554907 @default.
• W2111062014 hasConcept C86803240 @default.
• W2111062014 hasConcept C94561458 @default.
• W2111062014 hasConcept C95444343 @default.
• W2111062014 hasConceptScore W2111062014C11882975 @default.
• W2111062014 hasConceptScore W2111062014C11960822 @default.
• W2111062014 hasConceptScore W2111062014C1491633281 @default.
• W2111062014 hasConceptScore W2111062014C16438837 @default.
• W2111062014 hasConceptScore W2111062014C178666793 @default.
• W2111062014 hasConceptScore W2111062014C199835354 @default.
• W2111062014 hasConceptScore W2111062014C2777609662 @default.
• W2111062014 hasConceptScore W2111062014C29537977 @default.
• W2111062014 hasConceptScore W2111062014C502942594 @default.
• W2111062014 hasConceptScore W2111062014C55493867 @default.
• W2111062014 hasConceptScore W2111062014C62112901 @default.
• W2111062014 hasConceptScore W2111062014C62478195 @default.
• W2111062014 hasConceptScore W2111062014C75217442 @default.

• next