FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2111085594> ?p ?o ?g. }

• W2111085594 endingPage "1106" @default.
• W2111085594 startingPage "1093" @default.
• W2111085594 abstract "We investigated the in vivo role of CD69 by analyzing the susceptibility of CD69-/- mice to tumors. CD69-/- mice challenged with MHC class I- tumors (RMA-S and RM-1) showed greatly reduced tumor growth and prolonged survival compared with wild-type (WT) mice. The enhanced anti-tumor response was NK cell and T lymphocyte-mediated, and was due, at least in part, to an increase in local lymphocytes. Resistance of CD69-/- mice to MHC class I- tumor growth was also associated with increased production of the chemokine MCP-1, diminished TGF-beta production, and decreased lymphocyte apoptosis. Moreover, the in vivo blockade of TGF-beta in WT mice resulted in enhanced anti-tumor response. In addition, CD69 engagement induced NK and T cell production of TGF-beta, directly linking CD69 signaling to TGF-beta regulation. Furthermore, anti-CD69 antibody treatment in WT mice induced a specific down-regulation in CD69 expression that resulted in augmented anti-tumor response. These data unmask a novel role for CD69 as a negative regulator of anti-tumor responses and show the possibility of a novel approach for the therapy of tumors." @default.
• W2111085594 created "2016-06-24" @default.
• W2111085594 creator A5016766683 @default.
• W2111085594 creator A5020476146 @default.
• W2111085594 creator A5042124020 @default.
• W2111085594 creator A5047641235 @default.
• W2111085594 creator A5048542314 @default.
• W2111085594 creator A5051411928 @default.
• W2111085594 creator A5073496723 @default.
• W2111085594 creator A5073866069 @default.
• W2111085594 creator A5088455217 @default.
• W2111085594 date "2003-05-05" @default.
• W2111085594 modified "2023-10-18" @default.
• W2111085594 title "Enhanced Antitumor Immunity in Mice Deficient in CD69" @default.
• W2111085594 cites W1503228526 @default.
• W2111085594 cites W1532187041 @default.
• W2111085594 cites W1539667460 @default.
• W2111085594 cites W1574210410 @default.
• W2111085594 cites W1610241671 @default.
• W2111085594 cites W1642763135 @default.
• W2111085594 cites W1665894543 @default.
• W2111085594 cites W1944400542 @default.
• W2111085594 cites W1957245242 @default.
• W2111085594 cites W1964168638 @default.
• W2111085594 cites W1976662451 @default.
• W2111085594 cites W1978217003 @default.
• W2111085594 cites W1982051091 @default.
• W2111085594 cites W1984285433 @default.
• W2111085594 cites W2000208875 @default.
• W2111085594 cites W2009629707 @default.
• W2111085594 cites W2014125399 @default.
• W2111085594 cites W2025082986 @default.
• W2111085594 cites W2026831884 @default.
• W2111085594 cites W2031450009 @default.
• W2111085594 cites W2037416158 @default.
• W2111085594 cites W2039347592 @default.
• W2111085594 cites W2040074251 @default.
• W2111085594 cites W2044069347 @default.
• W2111085594 cites W2054276504 @default.
• W2111085594 cites W2059467769 @default.
• W2111085594 cites W2060819744 @default.
• W2111085594 cites W2063536921 @default.
• W2111085594 cites W2072286439 @default.
• W2111085594 cites W2076067786 @default.
• W2111085594 cites W2079721061 @default.
• W2111085594 cites W2081282655 @default.
• W2111085594 cites W2087739817 @default.
• W2111085594 cites W2105396692 @default.
• W2111085594 cites W2112736971 @default.
• W2111085594 cites W2118857294 @default.
• W2111085594 cites W2121462531 @default.
• W2111085594 cites W2126176554 @default.
• W2111085594 cites W2128434381 @default.
• W2111085594 cites W2129379081 @default.
• W2111085594 cites W2134408415 @default.
• W2111085594 cites W2140413450 @default.
• W2111085594 cites W2144318671 @default.
• W2111085594 cites W2149366474 @default.
• W2111085594 cites W2152384688 @default.
• W2111085594 cites W2158376848 @default.
• W2111085594 cites W2159181151 @default.
• W2111085594 cites W2167885584 @default.
• W2111085594 cites W2188271172 @default.
• W2111085594 cites W2412491909 @default.
• W2111085594 cites W4248052112 @default.
• W2111085594 doi "https://doi.org/10.1084/jem.20021337" @default.
• W2111085594 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2193974" @default.
• W2111085594 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12732655" @default.
• W2111085594 hasPublicationYear "2003" @default.
• W2111085594 type Work @default.
• W2111085594 sameAs 2111085594 @default.
• W2111085594 citedByCount "162" @default.
• W2111085594 countsByYear W21110855942012 @default.
• W2111085594 countsByYear W21110855942013 @default.
• W2111085594 countsByYear W21110855942014 @default.
• W2111085594 countsByYear W21110855942015 @default.
• W2111085594 countsByYear W21110855942016 @default.
• W2111085594 countsByYear W21110855942017 @default.
• W2111085594 countsByYear W21110855942018 @default.
• W2111085594 countsByYear W21110855942019 @default.
• W2111085594 countsByYear W21110855942020 @default.
• W2111085594 countsByYear W21110855942021 @default.
• W2111085594 countsByYear W21110855942022 @default.
• W2111085594 countsByYear W21110855942023 @default.
• W2111085594 crossrefType "journal-article" @default.
• W2111085594 hasAuthorship W2111085594A5016766683 @default.
• W2111085594 hasAuthorship W2111085594A5020476146 @default.
• W2111085594 hasAuthorship W2111085594A5042124020 @default.
• W2111085594 hasAuthorship W2111085594A5047641235 @default.
• W2111085594 hasAuthorship W2111085594A5048542314 @default.
• W2111085594 hasAuthorship W2111085594A5051411928 @default.
• W2111085594 hasAuthorship W2111085594A5073496723 @default.
• W2111085594 hasAuthorship W2111085594A5073866069 @default.
• W2111085594 hasAuthorship W2111085594A5088455217 @default.
• W2111085594 hasBestOaLocation W21110855941 @default.
• W2111085594 hasConcept C118131993 @default.
• W2111085594 hasConcept C150903083 @default.
• W2111085594 hasConcept C170627219 @default.

• next