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- W2111096670 abstract "Background:Telomeres are protective DNA-protein complexes at the ends of each chromosome, maintained primarily by the enzyme telomerase. Shortening of the blood leukocyte telomeres is associated with aging, several chronic diseases, and stress, eg, major depression. Hippocampus is pivotal in the regulation of cognition and mood and the main brain region of telomerase activity. Whether there is telomere dysfunction in the hippocampus of depressed subjects is unknown. Lithium, used in the treatment and relapse prevention of mood disorders, was found to protect against leukocyte telomere shortening in humans, but the mechanism has not been elucidated. To answer the questions whether telomeres are shortened and the telomerase activity changed in the hippocampus and whether lithium could reverse the process, we used a genetic model of depression, the Flinders Sensitive Line rat, and treated the animals with lithium." @default.
- W2111096670 created "2016-06-24" @default.
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- W2111096670 date "2015-01-24" @default.
- W2111096670 modified "2023-10-10" @default.
- W2111096670 title "Telomerase Dysregulation in the Hippocampus of a Rat Model of Depression: Normalization by Lithium" @default.
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- W2111096670 doi "https://doi.org/10.1093/ijnp/pyv002" @default.
- W2111096670 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4540104" @default.
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