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- W2111101118 abstract "One major limitation in the use of mammalian cells for the production of a product such as interferon is the technology for obtaining cells in sufficient quantity to meet the demands of the product’s usage. For the growth of surface-dependent mammalian cells, this problem translates into one of providing sufficient total surface area, and providing that surface in a configuration convenient for large scale process. The standard growth procedures using dishes and roller bottles are sufficient to meet the small scale demands of laboratory work, however, the scale up process for these systems presents many difficulties. Since each roller bottle has limited production capability, scale up is achieved by increasing the number of bottles used. This multiplicity of low productivity reactors is physically difficult to manipulate (e.g. for medium changes, or cell harvest) and virtually impossible to maintain in a homogeneous state." @default.
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- W2111101118 date "1978-01-01" @default.
- W2111101118 modified "2023-10-03" @default.
- W2111101118 title "New Microcarriers for the Large Scale Production of Anchorage-Dependent Mammalian Cells" @default.
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- W2111101118 doi "https://doi.org/10.1007/978-1-4615-9080-4_2" @default.
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