FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2111105486> ?p ?o ?g. }

• W2111105486 endingPage "8134" @default.
• W2111105486 startingPage "8124" @default.
• W2111105486 abstract "Tlx belongs to a class of orphan nuclear receptors that underlies many aspects of neural development in the CNS. However, the fundamental roles played by Tlx in the control of eye developmental programs remain elusive. By using Tlx knock-out (KO) mice, we show here that Tlx is expressed by retinal progenitor cells in the neuroblastic layer during the period of retinal layer formation, and it is critical for controlling the generation of appropriate numbers of retinal progenies through the activities of cell cycle-related molecules, cyclin D1 and p27Kip1. Tlx expression is restricted to Müller cells in the mature retina and appears to control their proper development. Furthermore, we show that Tlx is expressed by immature astrocytes that migrate from the optic nerve onto the inner surface of the retina and is required for their generation and maturation, as assessed by honeycomb network formation and expression of R-cadherin, a critical component for vasculogenesis. The impaired astrocyte network formation on the inner retinal surface is accompanied by the loss of vasculogenesis in Tlx KO retinas. Our studies thus indicate that Tlx underlies a fundamental developmental program of retinal organization and controls the generation of the proper numbers of retinal progenies and development of glial cells during the protracted period of retinogenesis." @default.
• W2111105486 created "2016-06-24" @default.
• W2111105486 creator A5025974163 @default.
• W2111105486 creator A5033683122 @default.
• W2111105486 creator A5037407184 @default.
• W2111105486 creator A5042188782 @default.
• W2111105486 creator A5049865258 @default.
• W2111105486 creator A5054512097 @default.
• W2111105486 creator A5056064034 @default.
• W2111105486 creator A5069518217 @default.
• W2111105486 creator A5076213811 @default.
• W2111105486 date "2004-09-15" @default.
• W2111105486 modified "2023-09-25" @default.
• W2111105486 title "Tlx, an Orphan Nuclear Receptor, Regulates Cell Numbers and Astrocyte Development in the Developing Retina" @default.
• W2111105486 cites W1488792046 @default.
• W2111105486 cites W1518744140 @default.
• W2111105486 cites W1533487943 @default.
• W2111105486 cites W1548002168 @default.
• W2111105486 cites W1676958442 @default.
• W2111105486 cites W1825846406 @default.
• W2111105486 cites W1833099573 @default.
• W2111105486 cites W1968703962 @default.
• W2111105486 cites W1970941733 @default.
• W2111105486 cites W1975477048 @default.
• W2111105486 cites W1976042069 @default.
• W2111105486 cites W1979762984 @default.
• W2111105486 cites W1993616699 @default.
• W2111105486 cites W2000700429 @default.
• W2111105486 cites W2004391147 @default.
• W2111105486 cites W2009708096 @default.
• W2111105486 cites W2012970553 @default.
• W2111105486 cites W2013949542 @default.
• W2111105486 cites W2019071873 @default.
• W2111105486 cites W2022734550 @default.
• W2111105486 cites W2022768206 @default.
• W2111105486 cites W2027150345 @default.
• W2111105486 cites W2028648973 @default.
• W2111105486 cites W2035819383 @default.
• W2111105486 cites W2040965438 @default.
• W2111105486 cites W2041598409 @default.
• W2111105486 cites W2052063322 @default.
• W2111105486 cites W2055985491 @default.
• W2111105486 cites W2058705034 @default.
• W2111105486 cites W2073295341 @default.
• W2111105486 cites W2077428235 @default.
• W2111105486 cites W2080937698 @default.
• W2111105486 cites W2091496842 @default.
• W2111105486 cites W2098526108 @default.
• W2111105486 cites W2103030751 @default.
• W2111105486 cites W2106271145 @default.
• W2111105486 cites W2107766440 @default.
• W2111105486 cites W2109652663 @default.
• W2111105486 cites W2115154324 @default.
• W2111105486 cites W2125578099 @default.
• W2111105486 cites W2141816015 @default.
• W2111105486 cites W2147352258 @default.
• W2111105486 cites W2147630434 @default.
• W2111105486 cites W2158654877 @default.
• W2111105486 cites W2162548132 @default.
• W2111105486 cites W2163016285 @default.
• W2111105486 cites W2167659174 @default.
• W2111105486 cites W2169813593 @default.
• W2111105486 cites W2172256092 @default.
• W2111105486 cites W2345333028 @default.
• W2111105486 cites W4256423782 @default.
• W2111105486 cites W8522198 @default.
• W2111105486 cites W87161001 @default.
• W2111105486 doi "https://doi.org/10.1523/jneurosci.2235-04.2004" @default.
• W2111105486 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6729803" @default.
• W2111105486 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15371513" @default.
• W2111105486 hasPublicationYear "2004" @default.
• W2111105486 type Work @default.
• W2111105486 sameAs 2111105486 @default.
• W2111105486 citedByCount "96" @default.
• W2111105486 countsByYear W21111054862012 @default.
• W2111105486 countsByYear W21111054862013 @default.
• W2111105486 countsByYear W21111054862014 @default.
• W2111105486 countsByYear W21111054862015 @default.
• W2111105486 countsByYear W21111054862016 @default.
• W2111105486 countsByYear W21111054862017 @default.
• W2111105486 countsByYear W21111054862018 @default.
• W2111105486 countsByYear W21111054862019 @default.
• W2111105486 countsByYear W21111054862020 @default.
• W2111105486 countsByYear W21111054862021 @default.
• W2111105486 countsByYear W21111054862022 @default.
• W2111105486 countsByYear W21111054862023 @default.
• W2111105486 crossrefType "journal-article" @default.
• W2111105486 hasAuthorship W2111105486A5025974163 @default.
• W2111105486 hasAuthorship W2111105486A5033683122 @default.
• W2111105486 hasAuthorship W2111105486A5037407184 @default.
• W2111105486 hasAuthorship W2111105486A5042188782 @default.
• W2111105486 hasAuthorship W2111105486A5049865258 @default.
• W2111105486 hasAuthorship W2111105486A5054512097 @default.
• W2111105486 hasAuthorship W2111105486A5056064034 @default.
• W2111105486 hasAuthorship W2111105486A5069518217 @default.
• W2111105486 hasAuthorship W2111105486A5076213811 @default.
• W2111105486 hasBestOaLocation W21111054861 @default.
• W2111105486 hasConcept C104317684 @default.

• next