Matches in SemOpenAlex for { <https://semopenalex.org/work/W2111107568> ?p ?o ?g. }
- W2111107568 endingPage "1441" @default.
- W2111107568 startingPage "1429" @default.
- W2111107568 abstract "RNA interference (RNAi) screening for cancer drug target identification has been growing, in both the number of laboratories carrying out screens and in the scale of the screens themselves, from the first screens that were published a few years ago. This growth is directly related to the significant new insights into cancer cell biology that have been defined by relatively few studies. Recently, such screens have moved from general studies of cancer cell function (finding new mechanisms of malignancy and tumor suppression), to screens that explain the clinical problems, such as resistance to chemotherapeutics. In light of the progression observed in these published studies, it is now possible to consider how RNAi screening can be used to characterize other areas of cancer research that have been proposed to explain the development of clinical cancers. Examples include: oncogene addiction/oncogenic shock, cancer stem cells, lineage dependency and the epithelial–mesenchymal transition. RNAi screening can enable critical evaluations of both the roles of these concepts in tumor development and provide starting points for new therapeutic programs targeting emerging areas of cancer cell biology." @default.
- W2111107568 created "2016-06-24" @default.
- W2111107568 creator A5064432529 @default.
- W2111107568 date "2007-10-26" @default.
- W2111107568 modified "2023-10-18" @default.
- W2111107568 title "Expanding the repertoire of RNA interference screens for developing new anticancer drug targets" @default.
- W2111107568 cites W1522234506 @default.
- W2111107568 cites W1565166977 @default.
- W2111107568 cites W1836834096 @default.
- W2111107568 cites W1891860149 @default.
- W2111107568 cites W1967641913 @default.
- W2111107568 cites W1968410036 @default.
- W2111107568 cites W1968916311 @default.
- W2111107568 cites W1974482866 @default.
- W2111107568 cites W1976046288 @default.
- W2111107568 cites W1977203585 @default.
- W2111107568 cites W1985136204 @default.
- W2111107568 cites W1985317603 @default.
- W2111107568 cites W1986191757 @default.
- W2111107568 cites W1993501781 @default.
- W2111107568 cites W1993669821 @default.
- W2111107568 cites W1995236496 @default.
- W2111107568 cites W1996810856 @default.
- W2111107568 cites W1998028009 @default.
- W2111107568 cites W1998990808 @default.
- W2111107568 cites W2000017794 @default.
- W2111107568 cites W2000342578 @default.
- W2111107568 cites W2002263141 @default.
- W2111107568 cites W2005219014 @default.
- W2111107568 cites W2006402174 @default.
- W2111107568 cites W2007978156 @default.
- W2111107568 cites W2008162612 @default.
- W2111107568 cites W2012124753 @default.
- W2111107568 cites W2015070217 @default.
- W2111107568 cites W2016246269 @default.
- W2111107568 cites W2016576850 @default.
- W2111107568 cites W2018556537 @default.
- W2111107568 cites W2019264784 @default.
- W2111107568 cites W2020333197 @default.
- W2111107568 cites W2023568503 @default.
- W2111107568 cites W2025216788 @default.
- W2111107568 cites W2025567758 @default.
- W2111107568 cites W2028368645 @default.
- W2111107568 cites W2033287248 @default.
- W2111107568 cites W2033797646 @default.
- W2111107568 cites W2034569328 @default.
- W2111107568 cites W2038863154 @default.
- W2111107568 cites W2040640949 @default.
- W2111107568 cites W2041141014 @default.
- W2111107568 cites W2041783360 @default.
- W2111107568 cites W2046387461 @default.
- W2111107568 cites W2048607934 @default.
- W2111107568 cites W2051000382 @default.
- W2111107568 cites W2052664143 @default.
- W2111107568 cites W2053741276 @default.
- W2111107568 cites W2055396579 @default.
- W2111107568 cites W2056561005 @default.
- W2111107568 cites W2057638670 @default.
- W2111107568 cites W2061050600 @default.
- W2111107568 cites W2064497478 @default.
- W2111107568 cites W2065285374 @default.
- W2111107568 cites W2067206898 @default.
- W2111107568 cites W2067838259 @default.
- W2111107568 cites W2068010171 @default.
- W2111107568 cites W2069379973 @default.
- W2111107568 cites W2069506489 @default.
- W2111107568 cites W2071853918 @default.
- W2111107568 cites W2075278057 @default.
- W2111107568 cites W2075744820 @default.
- W2111107568 cites W2080860848 @default.
- W2111107568 cites W2081028905 @default.
- W2111107568 cites W2083750996 @default.
- W2111107568 cites W2086401845 @default.
- W2111107568 cites W2087099947 @default.
- W2111107568 cites W2088199553 @default.
- W2111107568 cites W2089048280 @default.
- W2111107568 cites W2091161920 @default.
- W2111107568 cites W2092828528 @default.
- W2111107568 cites W2096387803 @default.
- W2111107568 cites W2097933346 @default.
- W2111107568 cites W2101355808 @default.
- W2111107568 cites W2105540740 @default.
- W2111107568 cites W2107409046 @default.
- W2111107568 cites W2107554012 @default.
- W2111107568 cites W2108303909 @default.
- W2111107568 cites W2117733300 @default.
- W2111107568 cites W2120059431 @default.
- W2111107568 cites W2121665844 @default.
- W2111107568 cites W2125053924 @default.
- W2111107568 cites W2129626105 @default.
- W2111107568 cites W2130208641 @default.
- W2111107568 cites W2131170195 @default.
- W2111107568 cites W2133898735 @default.
- W2111107568 cites W2139802966 @default.
- W2111107568 cites W2140551998 @default.
- W2111107568 cites W2143418697 @default.
- W2111107568 cites W2144654038 @default.
- W2111107568 cites W2147960762 @default.