FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2111111382> ?p ?o ?g. }

• W2111111382 endingPage "429" @default.
• W2111111382 startingPage "423" @default.
• W2111111382 abstract "Tobacco smoke causes lung cancer in smokers and in never-smokers exposed to second-hand tobacco smoke (SHS). Nonetheless, molecular mechanisms of lung cancer in SHS-exposed never-smokers are still elusive. We studied lung cancers from current smokers (n = 109), former smokers (n = 56) and never-smokers (n = 47) for promoter hypermethylation of five tumour suppressor genes—p16, RARB, RASSF1, MGMT and DAPK1—using methylation-specific polymerase chain reaction. Lung tumours from ever-smokers suggested an increased risk of p16 hypermethylation as compared to never-smokers (P = 0.073), with former smokers having the highest frequency of p16 hypermethylation (P = 0.044 versus current smokers and P = 0.009 versus never-smokers). In the never-smoking group, p16 hypermethylation was seen in lung tumours from SHS-exposed individuals (4/33; 12%) but in none of the non-exposed individuals (0/9). The overall occurrence of hypermethylation (measured both as methylation index and as number of genes affected) was similar in those ever exposed to tobacco smoke (smokers, SHS-exposed never-smokers) and differed from non-exposed never-smokers. In multivariate analysis, p16 hypermethylation was more prevalent in lung tumours from male than female patients (P = 0.018) and in squamous cell carcinomas than in adenocarcinomas (P = 0.025). Occurrence of TP53 mutation in the tumour was associated with hypermethylation of at least one gene (P = 0.027). In all, our data suggest that promoter hypermethylation pattern in SHS-exposed never-smokers resembles that observed in smokers. Association between TP53 mutation, a hallmark of smokers’ lung cancer, and methylation of one or more of the lung cancer-related genes studied, provides further evidence for common tobacco smoke-related origin for both types of molecular alterations." @default.
• W2111111382 created "2016-06-24" @default.
• W2111111382 creator A5017487533 @default.
• W2111111382 creator A5021007602 @default.
• W2111111382 creator A5041111796 @default.
• W2111111382 creator A5052503146 @default.
• W2111111382 creator A5052949222 @default.
• W2111111382 creator A5083154215 @default.
• W2111111382 creator A5085485237 @default.
• W2111111382 creator A5088847129 @default.
• W2111111382 date "2012-01-04" @default.
• W2111111382 modified "2023-10-06" @default.
• W2111111382 title "Similar DNA methylation pattern in lung tumours from smokers and never-smokers with second-hand tobacco smoke exposure" @default.
• W2111111382 cites W1836836079 @default.
• W2111111382 cites W1916639144 @default.
• W2111111382 cites W1973485587 @default.
• W2111111382 cites W1979109110 @default.
• W2111111382 cites W1987854385 @default.
• W2111111382 cites W1992409001 @default.
• W2111111382 cites W1994465394 @default.
• W2111111382 cites W2008696287 @default.
• W2111111382 cites W2020529787 @default.
• W2111111382 cites W2021678724 @default.
• W2111111382 cites W2025004154 @default.
• W2111111382 cites W2038181620 @default.
• W2111111382 cites W2041992600 @default.
• W2111111382 cites W2050619503 @default.
• W2111111382 cites W2059579018 @default.
• W2111111382 cites W2068394634 @default.
• W2111111382 cites W2077030176 @default.
• W2111111382 cites W2082776131 @default.
• W2111111382 cites W2092671982 @default.
• W2111111382 cites W2092761963 @default.
• W2111111382 cites W2110697049 @default.
• W2111111382 cites W2113459016 @default.
• W2111111382 cites W2113841146 @default.
• W2111111382 cites W2115860500 @default.
• W2111111382 cites W2117819670 @default.
• W2111111382 cites W2121701583 @default.
• W2111111382 cites W2129774558 @default.
• W2111111382 cites W2138145250 @default.
• W2111111382 cites W2140212173 @default.
• W2111111382 cites W2153354021 @default.
• W2111111382 cites W2159657105 @default.
• W2111111382 cites W2170956542 @default.
• W2111111382 cites W4229952372 @default.
• W2111111382 doi "https://doi.org/10.1093/mutage/ger092" @default.
• W2111111382 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22217548" @default.
• W2111111382 hasPublicationYear "2012" @default.
• W2111111382 type Work @default.
• W2111111382 sameAs 2111111382 @default.
• W2111111382 citedByCount "35" @default.
• W2111111382 countsByYear W21111113822012 @default.
• W2111111382 countsByYear W21111113822013 @default.
• W2111111382 countsByYear W21111113822014 @default.
• W2111111382 countsByYear W21111113822015 @default.
• W2111111382 countsByYear W21111113822016 @default.
• W2111111382 countsByYear W21111113822017 @default.
• W2111111382 countsByYear W21111113822018 @default.
• W2111111382 countsByYear W21111113822019 @default.
• W2111111382 countsByYear W21111113822020 @default.
• W2111111382 crossrefType "journal-article" @default.
• W2111111382 hasAuthorship W2111111382A5017487533 @default.
• W2111111382 hasAuthorship W2111111382A5021007602 @default.
• W2111111382 hasAuthorship W2111111382A5041111796 @default.
• W2111111382 hasAuthorship W2111111382A5052503146 @default.
• W2111111382 hasAuthorship W2111111382A5052949222 @default.
• W2111111382 hasAuthorship W2111111382A5083154215 @default.
• W2111111382 hasAuthorship W2111111382A5085485237 @default.
• W2111111382 hasAuthorship W2111111382A5088847129 @default.
• W2111111382 hasBestOaLocation W21111113821 @default.
• W2111111382 hasConcept C104317684 @default.
• W2111111382 hasConcept C126322002 @default.
• W2111111382 hasConcept C142724271 @default.
• W2111111382 hasConcept C143998085 @default.
• W2111111382 hasConcept C150194340 @default.
• W2111111382 hasConcept C190727270 @default.
• W2111111382 hasConcept C2776256026 @default.
• W2111111382 hasConcept C2777714996 @default.
• W2111111382 hasConcept C2778355491 @default.
• W2111111382 hasConcept C33288867 @default.
• W2111111382 hasConcept C502942594 @default.
• W2111111382 hasConcept C54355233 @default.
• W2111111382 hasConcept C71924100 @default.
• W2111111382 hasConcept C86803240 @default.
• W2111111382 hasConcept C99454951 @default.
• W2111111382 hasConceptScore W2111111382C104317684 @default.
• W2111111382 hasConceptScore W2111111382C126322002 @default.
• W2111111382 hasConceptScore W2111111382C142724271 @default.
• W2111111382 hasConceptScore W2111111382C143998085 @default.
• W2111111382 hasConceptScore W2111111382C150194340 @default.
• W2111111382 hasConceptScore W2111111382C190727270 @default.
• W2111111382 hasConceptScore W2111111382C2776256026 @default.
• W2111111382 hasConceptScore W2111111382C2777714996 @default.
• W2111111382 hasConceptScore W2111111382C2778355491 @default.
• W2111111382 hasConceptScore W2111111382C33288867 @default.
• W2111111382 hasConceptScore W2111111382C502942594 @default.
• W2111111382 hasConceptScore W2111111382C54355233 @default.

• next