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• W2111123102 abstract "Memory deficits produced by marijuana arise partly via interaction of the psychoactive component, Δ 9 -tetrahydrocannabinol (Δ 9 -THC), with cannabinoid receptors in the hippocampus. Although cannabinoids acutely reduce glutamate release and block hippocampal long-term potentiation (LTP), a potential substrate for learning and memory, the consequences of prolonged exposure to Δ 9 -THC for hippocampal function are poorly understood. Rats were injected with Δ 9 -THC (10 mg/kg, i.p., q.d.) for 1, 3, or 7 d, and electrophysiological recordings were performed in hippocampal slices 1d after the final injection. At this time, Δ 9 -THC was undetectable in hippocampus using liquid chromatography–mass spectrometry (LC-MS). Hippocampal LTP generated using high-frequency (HFS) or theta burst stimulation was not observed in brain slices from the 7-d Δ 9 -THC-treated animals. Δ 9 -THC also blocked HFS-LTP after 3 d, but not 1 d of treatment. The complete blockade of LTP persisted for 3 d after the last Δ 9 -THC injection, and full reversal of the LTP deficit was not observed up to 14 d following Δ 9 -THC withdrawal. The cannabinoid antagonist AM251 (2 mg/kg), administered before each Δ 9 -THC injection prevented the blockade of LTP, and 7-d treatment with AM251 alone significantly increased the level of LTP. Chronic Δ 9 -THC also produced tolerance to the inhibition of synaptic GABA, but not glutamate release by the agonist WIN55,212-2. These data define consequences of repeated Δ 9 -THC exposure for synaptic plasticity in the hippocampus that may help explain memory impairments in humans following chronic marijuana use." @default.
• W2111123102 created "2016-06-24" @default.
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• W2111123102 date "2007-01-01" @default.
• W2111123102 modified "2023-10-12" @default.
• W2111123102 title "Opposing actions of chronic Δ⁹-tetrahydrocannabinol and cannabinoid antagonists on hippocampal long-term potentiation" @default.
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• W2111123102 doi "https://doi.org/10.1101/lm.439007" @default.
• W2111123102 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1828281" @default.
• W2111123102 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17202425" @default.
• W2111123102 hasPublicationYear "2007" @default.
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