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- W2111124230 abstract "The association of preformed anti-donor Abs with the hyperacute rejection of bone marrow and solid organ allografts and the persistence of the anti-donor immune response secondary to immunologic memory make allosensitization an absolute contraindication to transplantation. Mixed allogeneic (A + B-->A) bone marrow chimerism has been demonstrated to confer donor-specific tolerance in nonsensitized recipients, but has not been evaluated in the setting of allosensitization. The current study documents that despite significant anti-donor sensitization, mixed allogeneic engraftment is possible and provides a marked advantage over fully allogeneic (B-->A) models. Moreover, the acceptance of donor skin grafts and loss of circulating anti-donor Abs suggest that allosensitization can be abrogated with the induction of stable mixed allogeneic chimerism." @default.
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- W2111124230 date "2000-07-15" @default.
- W2111124230 modified "2023-10-16" @default.
- W2111124230 title "The Abrogation of Allosensitization Following the Induction of Mixed Allogeneic Chimerism" @default.
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- W2111124230 doi "https://doi.org/10.4049/jimmunol.165.2.637" @default.
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