Matches in SemOpenAlex for { <https://semopenalex.org/work/W2111163370> ?p ?o ?g. }
- W2111163370 endingPage "822" @default.
- W2111163370 startingPage "813" @default.
- W2111163370 abstract "Localised hyperthermia in rodent studies is challenging due to the small target size. This study describes the development and characterisation of an MRI-compatible high-intensity focused ultrasound (HIFU) system to perform localised mild hyperthermia treatments in rodent models.The hyperthermia platform consisted of an MRI-compatible small animal HIFU system, focused transducers with sector-vortex lenses, a custom-made receive coil, and means to maintain systemic temperatures of rodents. The system was integrated into a 3T MR imager. Control software was developed to acquire images, process temperature maps, and adjust output power using a proportional-integral-derivative feedback control algorithm. Hyperthermia exposures were performed in tissue-mimicking phantoms and in a rodent model (n = 9). During heating, an ROI was assigned in the heated region for temperature control and the target temperature was 42 °C; 30 min mild hyperthermia treatment followed by a 10-min cooling procedure was performed on each animal.3D-printed sector-vortex lenses were successful at creating annular focal regions which enables customisation of the heating volume. Localised mild hyperthermia performed in rats produced a mean ROI temperature of 42.1 ± 0.3 °C. The T10 and T90 percentiles were 43.2 ± 0.4 °C and 41.0 ± 0.3 °C, respectively. For a 30-min treatment, the mean time duration between 41-45 °C was 31.1 min within the ROI.The MRI-compatible HIFU system was successfully adapted to perform localised mild hyperthermia treatment in rodent models. A target temperature of 42 °C was well-maintained in a rat thigh model for 30 min." @default.
- W2111163370 created "2016-06-24" @default.
- W2111163370 creator A5000162053 @default.
- W2111163370 creator A5009662027 @default.
- W2111163370 creator A5016094734 @default.
- W2111163370 creator A5058817270 @default.
- W2111163370 creator A5059302058 @default.
- W2111163370 creator A5065727479 @default.
- W2111163370 creator A5079851122 @default.
- W2111163370 date "2015-11-05" @default.
- W2111163370 modified "2023-10-11" @default.
- W2111163370 title "Localised hyperthermia in rodent models using an MRI-compatible high-intensity focused ultrasound system" @default.
- W2111163370 cites W1486075838 @default.
- W2111163370 cites W1513231719 @default.
- W2111163370 cites W1524400896 @default.
- W2111163370 cites W1532187345 @default.
- W2111163370 cites W1796027951 @default.
- W2111163370 cites W1964482344 @default.
- W2111163370 cites W1972683821 @default.
- W2111163370 cites W1972736234 @default.
- W2111163370 cites W1984780645 @default.
- W2111163370 cites W1991359745 @default.
- W2111163370 cites W1995435018 @default.
- W2111163370 cites W1996246843 @default.
- W2111163370 cites W1996745931 @default.
- W2111163370 cites W2003331591 @default.
- W2111163370 cites W2006742444 @default.
- W2111163370 cites W2011253107 @default.
- W2111163370 cites W2011896278 @default.
- W2111163370 cites W2016204586 @default.
- W2111163370 cites W2019090414 @default.
- W2111163370 cites W2020735811 @default.
- W2111163370 cites W2023910357 @default.
- W2111163370 cites W2025134678 @default.
- W2111163370 cites W2027458673 @default.
- W2111163370 cites W2033270735 @default.
- W2111163370 cites W2042405201 @default.
- W2111163370 cites W2043224691 @default.
- W2111163370 cites W2045151743 @default.
- W2111163370 cites W2045198632 @default.
- W2111163370 cites W2053821245 @default.
- W2111163370 cites W2054884916 @default.
- W2111163370 cites W2055471498 @default.
- W2111163370 cites W2065095088 @default.
- W2111163370 cites W2067076740 @default.
- W2111163370 cites W2074402330 @default.
- W2111163370 cites W2075325382 @default.
- W2111163370 cites W2087830691 @default.
- W2111163370 cites W2092650543 @default.
- W2111163370 cites W2095143577 @default.
- W2111163370 cites W2098816456 @default.
- W2111163370 cites W2101780183 @default.
- W2111163370 cites W2106055948 @default.
- W2111163370 cites W2108253062 @default.
- W2111163370 cites W2110171702 @default.
- W2111163370 cites W2119721348 @default.
- W2111163370 cites W2121924455 @default.
- W2111163370 cites W2123165631 @default.
- W2111163370 cites W2133220884 @default.
- W2111163370 cites W2134614210 @default.
- W2111163370 cites W2135272289 @default.
- W2111163370 cites W2160343486 @default.
- W2111163370 cites W2161038017 @default.
- W2111163370 cites W2418332641 @default.
- W2111163370 cites W4214939671 @default.
- W2111163370 cites W4236206700 @default.
- W2111163370 cites W4239673627 @default.
- W2111163370 cites W4240461768 @default.
- W2111163370 cites W4321429287 @default.
- W2111163370 doi "https://doi.org/10.3109/02656736.2015.1094833" @default.
- W2111163370 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4701604" @default.
- W2111163370 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26540488" @default.
- W2111163370 hasPublicationYear "2015" @default.
- W2111163370 type Work @default.
- W2111163370 sameAs 2111163370 @default.
- W2111163370 citedByCount "28" @default.
- W2111163370 countsByYear W21111633702016 @default.
- W2111163370 countsByYear W21111633702017 @default.
- W2111163370 countsByYear W21111633702018 @default.
- W2111163370 countsByYear W21111633702019 @default.
- W2111163370 countsByYear W21111633702020 @default.
- W2111163370 countsByYear W21111633702021 @default.
- W2111163370 countsByYear W21111633702022 @default.
- W2111163370 crossrefType "journal-article" @default.
- W2111163370 hasAuthorship W2111163370A5000162053 @default.
- W2111163370 hasAuthorship W2111163370A5009662027 @default.
- W2111163370 hasAuthorship W2111163370A5016094734 @default.
- W2111163370 hasAuthorship W2111163370A5058817270 @default.
- W2111163370 hasAuthorship W2111163370A5059302058 @default.
- W2111163370 hasAuthorship W2111163370A5065727479 @default.
- W2111163370 hasAuthorship W2111163370A5079851122 @default.
- W2111163370 hasBestOaLocation W21111633701 @default.
- W2111163370 hasConcept C126322002 @default.
- W2111163370 hasConcept C126838900 @default.
- W2111163370 hasConcept C136229726 @default.
- W2111163370 hasConcept C143753070 @default.
- W2111163370 hasConcept C192562407 @default.
- W2111163370 hasConcept C2777365067 @default.