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• W2111202021 endingPage "751" @default.
• W2111202021 startingPage "721" @default.
• W2111202021 abstract "Replication of the two template strands at eukaryotic cell DNA replication forks is a highly coordinated process that ensures accurate and efficient genome duplication. Biochemical studies, principally of plasmid DNAs containing the Simian Virus 40 origin of DNA replication, and yeast genetic studies have uncovered the fundamental mechanisms of replication fork progression. At least two different DNA polymerases, a single-stranded DNA-binding protein, a clamp-loading complex, and a polymerase clamp combine to replicate DNA. Okazaki fragment synthesis involves a DNA polymerase-switching mechanism, and maturation occurs by the recruitment of specific nucleases, a helicase, and a ligase. The process of DNA replication is also coupled to cell-cycle progression and to DNA repair to maintain genome integrity." @default.
• W2111202021 created "2016-06-24" @default.
• W2111202021 creator A5071437258 @default.
• W2111202021 creator A5080734532 @default.
• W2111202021 date "1998-06-01" @default.
• W2111202021 modified "2023-10-14" @default.
• W2111202021 title "THE DNA REPLICATION FORK IN EUKARYOTIC CELLS" @default.
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