FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2111215081> ?p ?o ?g. }

• W2111215081 endingPage "654" @default.
• W2111215081 startingPage "647" @default.
• W2111215081 abstract "The emergence of the swine-origin 2009 influenza pandemic illustrates the need for improved vaccine production and delivery strategies. Skin-based immunization represents an attractive alternative to traditional hypodermic needle vaccination routes. Microneedles (MNs) can deliver vaccine to the epidermis and dermis, which are rich in antigen-presenting cells (APC) such as Langerhans cells and dermal dendritic cells. Previous studies using coated or dissolvable microneedles emphasized the use of inactivated influenza virus or virus-like particles as skin-based vaccines. However, most currently available influenza vaccines consist of solubilized viral protein antigens. Here we test the hypothesis that a recombinant subunit influenza vaccine can be delivered to the skin by coated microneedles and can induce protective immunity. We found that mice vaccinated via MN delivery with a stabilized recombinant trimeric soluble hemagglutinin (sHA) derived from A/Aichi/2/68 (H3) virus had significantly higher immune responses than did mice vaccinated with unmodified sHA. These mice were fully protected against a lethal challenge with influenza virus. Analysis of postchallenge lung titers showed that MN-immunized mice had completely cleared the virus from their lungs, in contrast to mice given the same vaccine by a standard subcutaneous route. In addition, we observed a higher ratio of antigen-specific Th1 cells in trimeric sHA-vaccinated mice and a greater mucosal antibody response. Our data therefore demonstrate the improved efficacy of a skin-based recombinant subunit influenza vaccine and emphasize the advantage of this route of vaccination for a protein subunit vaccine." @default.
• W2111215081 created "2016-06-24" @default.
• W2111215081 creator A5005133857 @default.
• W2111215081 creator A5013167258 @default.
• W2111215081 creator A5030894404 @default.
• W2111215081 creator A5061434422 @default.
• W2111215081 creator A5062945460 @default.
• W2111215081 creator A5064720448 @default.
• W2111215081 creator A5065547249 @default.
• W2111215081 creator A5066669501 @default.
• W2111215081 date "2011-02-02" @default.
• W2111215081 modified "2023-09-27" @default.
• W2111215081 title "Microneedle Vaccination with Stabilized Recombinant Influenza Virus Hemagglutinin Induces Improved Protective Immunity" @default.
• W2111215081 cites W1493822493 @default.
• W2111215081 cites W1599778534 @default.
• W2111215081 cites W1840633113 @default.
• W2111215081 cites W1971630539 @default.
• W2111215081 cites W1972940026 @default.
• W2111215081 cites W1975223125 @default.
• W2111215081 cites W2009059447 @default.
• W2111215081 cites W2021970178 @default.
• W2111215081 cites W2027023890 @default.
• W2111215081 cites W2042194530 @default.
• W2111215081 cites W2049037588 @default.
• W2111215081 cites W2054370814 @default.
• W2111215081 cites W2060022949 @default.
• W2111215081 cites W2065579329 @default.
• W2111215081 cites W2071629929 @default.
• W2111215081 cites W2080430067 @default.
• W2111215081 cites W2084732117 @default.
• W2111215081 cites W2088354558 @default.
• W2111215081 cites W2089143024 @default.
• W2111215081 cites W2090299109 @default.
• W2111215081 cites W2090889765 @default.
• W2111215081 cites W2092637873 @default.
• W2111215081 cites W2107587363 @default.
• W2111215081 cites W2109757991 @default.
• W2111215081 cites W2111919101 @default.
• W2111215081 cites W2116085039 @default.
• W2111215081 cites W2120599736 @default.
• W2111215081 cites W2129208268 @default.
• W2111215081 cites W2134599862 @default.
• W2111215081 cites W2146357692 @default.
• W2111215081 cites W2147450297 @default.
• W2111215081 cites W2155467153 @default.
• W2111215081 cites W2157585612 @default.
• W2111215081 cites W2166851592 @default.
• W2111215081 cites W2167017590 @default.
• W2111215081 cites W2409984077 @default.
• W2111215081 cites W4248366088 @default.
• W2111215081 doi "https://doi.org/10.1128/cvi.00435-10" @default.
• W2111215081 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3122571" @default.
• W2111215081 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21288996" @default.
• W2111215081 hasPublicationYear "2011" @default.
• W2111215081 type Work @default.
• W2111215081 sameAs 2111215081 @default.
• W2111215081 citedByCount "65" @default.
• W2111215081 countsByYear W21112150812012 @default.
• W2111215081 countsByYear W21112150812013 @default.
• W2111215081 countsByYear W21112150812014 @default.
• W2111215081 countsByYear W21112150812015 @default.
• W2111215081 countsByYear W21112150812016 @default.
• W2111215081 countsByYear W21112150812017 @default.
• W2111215081 countsByYear W21112150812018 @default.
• W2111215081 countsByYear W21112150812019 @default.
• W2111215081 countsByYear W21112150812020 @default.
• W2111215081 countsByYear W21112150812021 @default.
• W2111215081 countsByYear W21112150812022 @default.
• W2111215081 countsByYear W21112150812023 @default.
• W2111215081 crossrefType "journal-article" @default.
• W2111215081 hasAuthorship W2111215081A5005133857 @default.
• W2111215081 hasAuthorship W2111215081A5013167258 @default.
• W2111215081 hasAuthorship W2111215081A5030894404 @default.
• W2111215081 hasAuthorship W2111215081A5061434422 @default.
• W2111215081 hasAuthorship W2111215081A5062945460 @default.
• W2111215081 hasAuthorship W2111215081A5064720448 @default.
• W2111215081 hasAuthorship W2111215081A5065547249 @default.
• W2111215081 hasAuthorship W2111215081A5066669501 @default.
• W2111215081 hasBestOaLocation W21112150812 @default.
• W2111215081 hasConcept C105702510 @default.
• W2111215081 hasConcept C147483822 @default.
• W2111215081 hasConcept C159047783 @default.
• W2111215081 hasConcept C203014093 @default.
• W2111215081 hasConcept C22070199 @default.
• W2111215081 hasConcept C2522874641 @default.
• W2111215081 hasConcept C2777546802 @default.
• W2111215081 hasConcept C2777624698 @default.
• W2111215081 hasConcept C2778692840 @default.
• W2111215081 hasConcept C2779341262 @default.
• W2111215081 hasConcept C2780689484 @default.
• W2111215081 hasConcept C2780801004 @default.
• W2111215081 hasConcept C86803240 @default.
• W2111215081 hasConcept C8891405 @default.
• W2111215081 hasConceptScore W2111215081C105702510 @default.
• W2111215081 hasConceptScore W2111215081C147483822 @default.
• W2111215081 hasConceptScore W2111215081C159047783 @default.
• W2111215081 hasConceptScore W2111215081C203014093 @default.
• W2111215081 hasConceptScore W2111215081C22070199 @default.

• next