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• W2111230107 abstract "The activation of maturation-promoting factor (MPF) is required for G(2)/M progression in eukaryotic cells. Xenopus oocytes are arrested in G(2) and are induced to enter M phase of meiosis by progesterone stimulation. This process is known as meiotic maturation and requires the translation of specific maternal mRNAs stored in the oocytes. We have used an expression cloning strategy to functionally identify proteins involved in G(2)/M progression in Xenopus oocytes. Here we report the cloning of two novel cDNAs that when expressed in oocytes induce meiotic maturation efficiently. The two cDNAs encode proteins of 33 kD that are 88% identical and have no significant homologies to other sequences in databases. These proteins, which we refer to as p33(ringo) (rapid inducer of G(2)/M progression in oocytes), induce very rapid MPF activation in cycloheximide-treated oocytes. Conversely, ablation of endogenous p33(ringo) mRNAs using antisense oligonucleotides inhibits progesterone-induced maturation, suggesting that synthesis of p33(ringo) is required for this process. We also show that p33(ringo) binds to and activates the kinase activity of p34(cdc2) but does not associate with p34(cdc2)/cyclin B complexes. Our results identify a novel p34(cdc2) binding and activating protein that regulates the G(2)/M transition during oocyte maturation." @default.
• W2111230107 created "2016-06-24" @default.
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• W2111230107 date "1999-08-15" @default.
• W2111230107 modified "2023-10-17" @default.
• W2111230107 title "A novel p34cdc2-binding and activating protein that is necessary and sufficient to trigger G2/M progression in Xenopus oocytes" @default.
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• W2111230107 doi "https://doi.org/10.1101/gad.13.16.2177" @default.
• W2111230107 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/316955" @default.
• W2111230107 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10465793" @default.
• W2111230107 hasPublicationYear "1999" @default.
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