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- W2111230462 abstract "Strohl, Kingman P., Agnes J. Thomas, Pamela St. Jean, Evelyn H. Schlenker, Richard J. Koletsky, and Nicholas J. Schork.Ventilation and metabolism among rat strains. J. Appl. Physiol. 82(1): 317–323, 1997.—We examined ventilation and metabolism in four rat strains with variation in traits for body weight and/or blood pressure regulation. Sprague-Dawley [SD; 8 males (M), 8 females (F)], Brown Norway (BN; 10 M, 11 F), and Zucker (Z; 11 M, 12 F) rats were compared with Koletsky (K; 11 M, 11 F) rats. With the use of noninvasive plethysmography, frequency, tidal volume, minute ventilation (V˙e), O 2 consumption, and CO 2 production were derived at rest during normoxia (room air) and during the 5th minute of exposure to each of the following: hyperoxia (100% O 2 ), hypoxia (10% O 2 -balance N 2 ), and hypercapnia (7% CO 2 -balance O 2 ). Statistical methods probed for strain and sex effects, with covariant analysis by body weight, length, and body mass. During resting breathing, strain effects were found with respect to both frequency (BN, Z > K, SD) and tidal volume (SD > BN, Z) but not to V˙e. Sex influenced frequency (F > M) alone. Z rats had higher values for O 2 consumption, CO 2 production, and respiratory quotient than the other three strains, with no independent effect by sex. During hyperoxia, frequency was greater in BN and Z than in SD or K rats; SD rats had a larger tidal volume than BN or Z rats; Z rats had a greater V˙e than K rats; and M had a larger tidal volume than F. Strain differences persisted during hypercapnia, with Z rats exhibiting the highest frequency andV˙e values. During hypoxic exposure, strain effects were found to influenceV˙e (SD > K, Z), frequency (BN > K), and tidal volume (SD > BN, K, Z). Body mass was only a modest predictor of V˙e during normoxia, of both V˙e and tidal volume with hypoxia, hypercapnia, or hyperoxia, and of frequency during hypercapnia. We conclude that strain of rats, more than their body mass or sex, has major and different influences on metabolism, the pattern and level of ventilation during air breathing, and ventilation during acute exposure to hypercapnia or hypoxia." @default.
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- W2111230462 date "1997-01-01" @default.
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- W2111230462 title "Ventilation and metabolism among rat strains" @default.
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- W2111230462 doi "https://doi.org/10.1152/jappl.1997.82.1.317" @default.
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