FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2111232291> ?p ?o ?g. }

• W2111232291 endingPage "565" @default.
• W2111232291 startingPage "558" @default.
• W2111232291 abstract "Purpose of review Antibodies to muscle-specific tyrosine kinase (MuSK) characterize up to 5% of myasthenia gravis patients. This review focuses on the differences to clinical antiacetylcholine receptor-myasthenia gravis, and on the physiology and animal studies that elucidate the role of MuSK and help explain the clinical disease. Recent findings MuSK forms the core of a protein complex in the postsynaptic membrane at the neuromuscular junction. During development, MuSK tyrosine kinase signaling is vital for the formation and stabilization of the postsynaptic endplate; it is now clear that long-term homeostasis of mature neuromuscular junctions requires MuSK function. Patient MuSK-antibodies are largely of the IgG4 type and in cell culture block the assembly and activation of MuSK kinase. Active immunization and passive transfer mouse models show reduced postsynaptic acetylcholine receptors and disturbed synaptic alignment, diminished synaptic potentials and impaired muscle activation. MuSK myasthenia gravis patients display particular bulbar and respiratory muscle involvement, with a high rate of myasthenic crises. Plasma exchange and immunosuppression with corticosteroids and rituximab appear to be most effective in treating MuSK myasthenia gravis. In contrast, the cholinesterase inhibitors, such as pyridostigmine, appear less suitable for this form of myasthenia gravis. Summary MuSK myasthenia gravis has distinct clinical and pathophysiological features. https://links.lww.com/CONR/A29" @default.
• W2111232291 created "2016-06-24" @default.
• W2111232291 creator A5022454523 @default.
• W2111232291 creator A5023921458 @default.
• W2111232291 creator A5082301295 @default.
• W2111232291 date "2014-10-01" @default.
• W2111232291 modified "2023-10-16" @default.
• W2111232291 title "Clinical and scientific aspects of muscle-specific tyrosine kinase-related myasthenia gravis" @default.
• W2111232291 cites W1503767635 @default.
• W2111232291 cites W1540450162 @default.
• W2111232291 cites W1568142966 @default.
• W2111232291 cites W1582195095 @default.
• W2111232291 cites W1952071932 @default.
• W2111232291 cites W1977090363 @default.
• W2111232291 cites W1984405077 @default.
• W2111232291 cites W1985640284 @default.
• W2111232291 cites W1988570220 @default.
• W2111232291 cites W1990099133 @default.
• W2111232291 cites W1993458746 @default.
• W2111232291 cites W1993663077 @default.
• W2111232291 cites W1994793581 @default.
• W2111232291 cites W1999553070 @default.
• W2111232291 cites W2000937305 @default.
• W2111232291 cites W2007294766 @default.
• W2111232291 cites W2019361437 @default.
• W2111232291 cites W2028595146 @default.
• W2111232291 cites W2038810897 @default.
• W2111232291 cites W2042829451 @default.
• W2111232291 cites W2043698418 @default.
• W2111232291 cites W2044008059 @default.
• W2111232291 cites W2045388885 @default.
• W2111232291 cites W2047379519 @default.
• W2111232291 cites W2051055466 @default.
• W2111232291 cites W2052823664 @default.
• W2111232291 cites W2053386121 @default.
• W2111232291 cites W2065820678 @default.
• W2111232291 cites W2066239289 @default.
• W2111232291 cites W2066462296 @default.
• W2111232291 cites W2072414646 @default.
• W2111232291 cites W2072475795 @default.
• W2111232291 cites W2078654174 @default.
• W2111232291 cites W2079566005 @default.
• W2111232291 cites W2091359415 @default.
• W2111232291 cites W2102593255 @default.
• W2111232291 cites W2104640599 @default.
• W2111232291 cites W2107024251 @default.
• W2111232291 cites W2108207836 @default.
• W2111232291 cites W2111470622 @default.
• W2111232291 cites W2113602915 @default.
• W2111232291 cites W2114428731 @default.
• W2111232291 cites W2118177888 @default.
• W2111232291 cites W2133957385 @default.
• W2111232291 cites W2144090483 @default.
• W2111232291 cites W2150947283 @default.
• W2111232291 cites W2155823199 @default.
• W2111232291 cites W2158208349 @default.
• W2111232291 cites W2160330118 @default.
• W2111232291 cites W2162856159 @default.
• W2111232291 cites W2170822425 @default.
• W2111232291 cites W2171563433 @default.
• W2111232291 cites W2171746034 @default.
• W2111232291 cites W2325360414 @default.
• W2111232291 cites W4248406156 @default.
• W2111232291 doi "https://doi.org/10.1097/wco.0000000000000136" @default.
• W2111232291 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25159928" @default.
• W2111232291 hasPublicationYear "2014" @default.
• W2111232291 type Work @default.
• W2111232291 sameAs 2111232291 @default.
• W2111232291 citedByCount "25" @default.
• W2111232291 countsByYear W21112322912015 @default.
• W2111232291 countsByYear W21112322912016 @default.
• W2111232291 countsByYear W21112322912017 @default.
• W2111232291 countsByYear W21112322912018 @default.
• W2111232291 countsByYear W21112322912019 @default.
• W2111232291 countsByYear W21112322912020 @default.
• W2111232291 countsByYear W21112322912021 @default.
• W2111232291 countsByYear W21112322912022 @default.
• W2111232291 countsByYear W21112322912023 @default.
• W2111232291 crossrefType "journal-article" @default.
• W2111232291 hasAuthorship W2111232291A5022454523 @default.
• W2111232291 hasAuthorship W2111232291A5023921458 @default.
• W2111232291 hasAuthorship W2111232291A5082301295 @default.
• W2111232291 hasConcept C126322002 @default.
• W2111232291 hasConcept C134018914 @default.
• W2111232291 hasConcept C169760540 @default.
• W2111232291 hasConcept C170493617 @default.
• W2111232291 hasConcept C197341189 @default.
• W2111232291 hasConcept C203014093 @default.
• W2111232291 hasConcept C2777240379 @default.
• W2111232291 hasConcept C2778105408 @default.
• W2111232291 hasConcept C2779024559 @default.
• W2111232291 hasConcept C2779901103 @default.
• W2111232291 hasConcept C2910532367 @default.
• W2111232291 hasConcept C3020341438 @default.
• W2111232291 hasConcept C42362537 @default.
• W2111232291 hasConcept C71924100 @default.
• W2111232291 hasConcept C80161118 @default.
• W2111232291 hasConcept C86803240 @default.

• next