FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2111241623> ?p ?o ?g. }

• W2111241623 endingPage "149" @default.
• W2111241623 startingPage "144" @default.
• W2111241623 abstract "This study investigated the association between polymorphisms in vascular endothelial growth factor (VEGF) gene (‐1558C‐T, ‐1190A‐G and ‐1154A‐G) and age at onset of amyotrophic lateral sclerosis (ALS). Between July 2000 and June 2004 we conducted a clinical genetic study at Peking University Third Hospital, China. The analyses included a total of 93 ALS patients. Genotyping was performed by using the 5′‐nuclease assay technology (Applied Biosystems) with TaqMan® allele‐specific fluorogenic oligonucleotide probes. We used multivariate linear regression modelling and haplotype‐based association test to analyse the association of VEGF gene polymorphisms with the age of onset, adjusting for initial symptoms and sex. The results indicated that patients with the ‐1190A/G and ‐1190G/G genotypes exhibited about a 4.1‐ and 9.4‐years earlier onset of ALS than the patients with the ‐1190A/A genotype. A similar pattern emerged when the VEGF ‐1154A‐G gene was considered: the β was −7.9(p<0.001) years and −11.7(p<0.001) years for ‐1154A/G and ‐1154G/G genotypes, respectively. The VEGF ‐1558C‐T had a positive effect in the ‐1558C/T group (p = 0.007, β = 7.0) and ‐1558T/T (p<0.001, β = 9.6) compared to the ‐1558C/C group. We neither observed an interaction nor haplotype association with age onset among ‐1558C‐T, ‐1190A‐G and ‐1154A‐G. In conclusion, our results indicate, for the first time, that there was an important association between the polymorphism of the VEGF gene and age of ALS onset. This suggests a possible role for VEGF variability in the aetiology of individual differences in ALS onset." @default.
• W2111241623 created "2016-06-24" @default.
• W2111241623 creator A5002769825 @default.
• W2111241623 creator A5003331841 @default.
• W2111241623 creator A5029954793 @default.
• W2111241623 creator A5041131094 @default.
• W2111241623 creator A5048894919 @default.
• W2111241623 creator A5052787170 @default.
• W2111241623 creator A5054212578 @default.
• W2111241623 creator A5063897374 @default.
• W2111241623 creator A5067435138 @default.
• W2111241623 creator A5076594495 @default.
• W2111241623 creator A5083093957 @default.
• W2111241623 date "2007-01-01" @default.
• W2111241623 modified "2023-10-18" @default.
• W2111241623 title "Association of polymorphisms in vascular endothelial growth factor gene with the age of onset of amyotrophic lateral sclerosis" @default.
• W2111241623 cites W1495287184 @default.
• W2111241623 cites W1513780852 @default.
• W2111241623 cites W1537712767 @default.
• W2111241623 cites W1894493322 @default.
• W2111241623 cites W1962154683 @default.
• W2111241623 cites W1967542752 @default.
• W2111241623 cites W1971763706 @default.
• W2111241623 cites W1972760525 @default.
• W2111241623 cites W1974036700 @default.
• W2111241623 cites W1977403167 @default.
• W2111241623 cites W1987522740 @default.
• W2111241623 cites W2005808616 @default.
• W2111241623 cites W2010595485 @default.
• W2111241623 cites W2014386715 @default.
• W2111241623 cites W2016471106 @default.
• W2111241623 cites W2021856689 @default.
• W2111241623 cites W2022008510 @default.
• W2111241623 cites W2024009556 @default.
• W2111241623 cites W2030176537 @default.
• W2111241623 cites W2033643451 @default.
• W2111241623 cites W2033831066 @default.
• W2111241623 cites W2034842853 @default.
• W2111241623 cites W2052818103 @default.
• W2111241623 cites W2053272214 @default.
• W2111241623 cites W2064640860 @default.
• W2111241623 cites W2077688090 @default.
• W2111241623 cites W2116079297 @default.
• W2111241623 cites W2123779560 @default.
• W2111241623 cites W2133811999 @default.
• W2111241623 cites W2147706488 @default.
• W2111241623 cites W2043047716 @default.
• W2111241623 doi "https://doi.org/10.1080/17482960601179373" @default.
• W2111241623 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17538775" @default.
• W2111241623 hasPublicationYear "2007" @default.
• W2111241623 type Work @default.
• W2111241623 sameAs 2111241623 @default.
• W2111241623 citedByCount "9" @default.
• W2111241623 countsByYear W21112416232014 @default.
• W2111241623 countsByYear W21112416232015 @default.
• W2111241623 countsByYear W21112416232016 @default.
• W2111241623 countsByYear W21112416232018 @default.
• W2111241623 crossrefType "journal-article" @default.
• W2111241623 hasAuthorship W2111241623A5002769825 @default.
• W2111241623 hasAuthorship W2111241623A5003331841 @default.
• W2111241623 hasAuthorship W2111241623A5029954793 @default.
• W2111241623 hasAuthorship W2111241623A5041131094 @default.
• W2111241623 hasAuthorship W2111241623A5048894919 @default.
• W2111241623 hasAuthorship W2111241623A5052787170 @default.
• W2111241623 hasAuthorship W2111241623A5054212578 @default.
• W2111241623 hasAuthorship W2111241623A5063897374 @default.
• W2111241623 hasAuthorship W2111241623A5067435138 @default.
• W2111241623 hasAuthorship W2111241623A5076594495 @default.
• W2111241623 hasAuthorship W2111241623A5083093957 @default.
• W2111241623 hasConcept C104317684 @default.
• W2111241623 hasConcept C126322002 @default.
• W2111241623 hasConcept C135763542 @default.
• W2111241623 hasConcept C143998085 @default.
• W2111241623 hasConcept C153209595 @default.
• W2111241623 hasConcept C167734588 @default.
• W2111241623 hasConcept C180754005 @default.
• W2111241623 hasConcept C197754878 @default.
• W2111241623 hasConcept C2777025900 @default.
• W2111241623 hasConcept C2779134260 @default.
• W2111241623 hasConcept C2780596555 @default.
• W2111241623 hasConcept C31467283 @default.
• W2111241623 hasConcept C54355233 @default.
• W2111241623 hasConcept C71924100 @default.
• W2111241623 hasConcept C86803240 @default.
• W2111241623 hasConcept C90924648 @default.
• W2111241623 hasConceptScore W2111241623C104317684 @default.
• W2111241623 hasConceptScore W2111241623C126322002 @default.
• W2111241623 hasConceptScore W2111241623C135763542 @default.
• W2111241623 hasConceptScore W2111241623C143998085 @default.
• W2111241623 hasConceptScore W2111241623C153209595 @default.
• W2111241623 hasConceptScore W2111241623C167734588 @default.
• W2111241623 hasConceptScore W2111241623C180754005 @default.
• W2111241623 hasConceptScore W2111241623C197754878 @default.
• W2111241623 hasConceptScore W2111241623C2777025900 @default.
• W2111241623 hasConceptScore W2111241623C2779134260 @default.
• W2111241623 hasConceptScore W2111241623C2780596555 @default.
• W2111241623 hasConceptScore W2111241623C31467283 @default.
• W2111241623 hasConceptScore W2111241623C54355233 @default.

• next