Matches in SemOpenAlex for { <https://semopenalex.org/work/W2111266833> ?p ?o ?g. }
- W2111266833 endingPage "e27480" @default.
- W2111266833 startingPage "e27480" @default.
- W2111266833 abstract "Plants provide a rich source of lead compounds for a variety of diseases. A novel approach combining phytochemistry and chemotaxis assays was developed and used to identify and study the mechanisms of action of the active compounds in F. japonica, a medicinal herb traditionally used to treat inflammation. Based on a bioactivity-guided purification strategy, two anthranoids, emodin and physcion, were identified from F. japonica. Spectroscopic techniques were used to characterize its crude extract, fractions and phytochemicals. The crude extract, chloroform fraction, and anthranoids of F. japonica significantly inhibited CXCR4-mediated chemotaxis. Mechanistic studies showed that emodin and physcion inhibited chemotaxis via inactivating the MEK/ERK pathway. Moreover, the crude extract and emodin could prevent or treat type 1 diabetes in non-obese diabetic (NOD) mice. This study illustrates the applicability of a combinational approach for the study of anti-inflammatory medicine and shows the potential of F. japonica and its anthranoids for anti-inflammatory therapy." @default.
- W2111266833 created "2016-06-24" @default.
- W2111266833 creator A5000624030 @default.
- W2111266833 creator A5002487375 @default.
- W2111266833 creator A5004474883 @default.
- W2111266833 creator A5032805806 @default.
- W2111266833 creator A5034284503 @default.
- W2111266833 creator A5040930956 @default.
- W2111266833 creator A5043281977 @default.
- W2111266833 creator A5050661792 @default.
- W2111266833 creator A5053972239 @default.
- W2111266833 creator A5073813958 @default.
- W2111266833 creator A5076677322 @default.
- W2111266833 creator A5084793955 @default.
- W2111266833 creator A5088665887 @default.
- W2111266833 creator A5090220753 @default.
- W2111266833 date "2011-11-08" @default.
- W2111266833 modified "2023-10-13" @default.
- W2111266833 title "Combined Phytochemistry and Chemotaxis Assays for Identification and Mechanistic Analysis of Anti-Inflammatory Phytochemicals in Fallopia japonica" @default.
- W2111266833 cites W1501778305 @default.
- W2111266833 cites W1875008703 @default.
- W2111266833 cites W1881147845 @default.
- W2111266833 cites W1963957869 @default.
- W2111266833 cites W1964628210 @default.
- W2111266833 cites W1964986597 @default.
- W2111266833 cites W1984361639 @default.
- W2111266833 cites W1985185410 @default.
- W2111266833 cites W1986544445 @default.
- W2111266833 cites W1986550733 @default.
- W2111266833 cites W1987062124 @default.
- W2111266833 cites W1988912859 @default.
- W2111266833 cites W1997327340 @default.
- W2111266833 cites W2005975965 @default.
- W2111266833 cites W2013899416 @default.
- W2111266833 cites W2015200132 @default.
- W2111266833 cites W2027967215 @default.
- W2111266833 cites W2039220450 @default.
- W2111266833 cites W2040123299 @default.
- W2111266833 cites W2053714584 @default.
- W2111266833 cites W2066070305 @default.
- W2111266833 cites W2075782505 @default.
- W2111266833 cites W2081275257 @default.
- W2111266833 cites W2083339182 @default.
- W2111266833 cites W2084784717 @default.
- W2111266833 cites W2088730492 @default.
- W2111266833 cites W2089821948 @default.
- W2111266833 cites W2096211018 @default.
- W2111266833 cites W2103608836 @default.
- W2111266833 cites W2114784330 @default.
- W2111266833 cites W2114968425 @default.
- W2111266833 cites W2121199088 @default.
- W2111266833 cites W2130839195 @default.
- W2111266833 cites W2134296389 @default.
- W2111266833 cites W2145005766 @default.
- W2111266833 cites W2151089147 @default.
- W2111266833 cites W2154229564 @default.
- W2111266833 cites W2160217859 @default.
- W2111266833 cites W2164858484 @default.
- W2111266833 cites W2168186940 @default.
- W2111266833 cites W2174038709 @default.
- W2111266833 cites W2399631586 @default.
- W2111266833 cites W2412052054 @default.
- W2111266833 cites W5016645 @default.
- W2111266833 cites W2883871681 @default.
- W2111266833 doi "https://doi.org/10.1371/journal.pone.0027480" @default.
- W2111266833 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3210798" @default.
- W2111266833 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22087325" @default.
- W2111266833 hasPublicationYear "2011" @default.
- W2111266833 type Work @default.
- W2111266833 sameAs 2111266833 @default.
- W2111266833 citedByCount "22" @default.
- W2111266833 countsByYear W21112668332013 @default.
- W2111266833 countsByYear W21112668332014 @default.
- W2111266833 countsByYear W21112668332015 @default.
- W2111266833 countsByYear W21112668332016 @default.
- W2111266833 countsByYear W21112668332017 @default.
- W2111266833 countsByYear W21112668332019 @default.
- W2111266833 countsByYear W21112668332020 @default.
- W2111266833 countsByYear W21112668332021 @default.
- W2111266833 countsByYear W21112668332022 @default.
- W2111266833 countsByYear W21112668332023 @default.
- W2111266833 crossrefType "journal-article" @default.
- W2111266833 hasAuthorship W2111266833A5000624030 @default.
- W2111266833 hasAuthorship W2111266833A5002487375 @default.
- W2111266833 hasAuthorship W2111266833A5004474883 @default.
- W2111266833 hasAuthorship W2111266833A5032805806 @default.
- W2111266833 hasAuthorship W2111266833A5034284503 @default.
- W2111266833 hasAuthorship W2111266833A5040930956 @default.
- W2111266833 hasAuthorship W2111266833A5043281977 @default.
- W2111266833 hasAuthorship W2111266833A5050661792 @default.
- W2111266833 hasAuthorship W2111266833A5053972239 @default.
- W2111266833 hasAuthorship W2111266833A5073813958 @default.
- W2111266833 hasAuthorship W2111266833A5076677322 @default.
- W2111266833 hasAuthorship W2111266833A5084793955 @default.
- W2111266833 hasAuthorship W2111266833A5088665887 @default.
- W2111266833 hasAuthorship W2111266833A5090220753 @default.
- W2111266833 hasBestOaLocation W21112668331 @default.
- W2111266833 hasConcept C170493617 @default.