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- W2111270260 abstract "SUMMARY Chagas' disease is a debilitating but comparatively neglected illness that affects about 15 million people. There is an urgent need to develop new, more effective, and less-toxic compounds. In this study, we assessed the in vitro anti-trypanosomal activity of the sesquiterpene elatol from the Brazilian red seaweed Laurencia dendroidea . We used electron microscopy to evaluate the effect of elatol on the morphology and ultrastructure of the parasite. Elatol showed a dose-dependent effect against the epimastigote, trypomastigote, and amastigote forms, with IC 50 values of 45·4, 1·38, and 1·01 μ m , respectively. Observation of treated intracellular amastigotes by light microscopy demonstrated a total elimination of the infection at a dose of 3·0 μ m . In addition, the compound did not affect the red blood cells, and the CC 50 value for LLCMK 2 cells was 27·0 μ m . Transmission and scanning electron micrographs showed aberrant-shaped cells and breaks in the plasma membrane, prominent swollen mitochondria, and extensive formation of cytoplasmic vacuoles in all the forms. This is the first report of the anti-trypanosomal effect of the sesquiterpene elatol." @default.
- W2111270260 created "2016-06-24" @default.
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- W2111270260 date "2010-06-14" @default.
- W2111270260 modified "2023-10-18" @default.
- W2111270260 title "<i>In vitro</i> anti-trypanosomal activity of elatol isolated from red seaweed <i>Laurencia dendroidea</i>" @default.
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- W2111270260 doi "https://doi.org/10.1017/s003118201000034x" @default.
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