Matches in SemOpenAlex for { <https://semopenalex.org/work/W2111282720> ?p ?o ?g. }
- W2111282720 endingPage "2607" @default.
- W2111282720 startingPage "2597" @default.
- W2111282720 abstract "The etiology of inflammatory bowel disease is not completely known, but it is influenced by the presence of normal gut microflora as well as yet-unrecognized pathogens. The anaerobic, Gram-negative bacterial species Fusobacterium nucleatum is a common resident of the human mouth and gut and varies in its pathogenic potential. In this study, we demonstrate that highly invasive F. nucleatum isolates derived from the inflamed guts of Crohn's disease patients evoked significantly greater MUC2 and tumor necrosis factor alpha (TNF-α) gene expression than minimally invasive strains isolated from the noninflamed gut in human colonic epithelial cells and in a rat ligated colonic loop model of infection. Only live F. nucleatum induced mucin secretion and TNF-α expression in direct contact with and/or during invasion of colonic cells. In rat colons, mucin secretion was augmented in response to a highly invasive F. nucleatum isolate but was unaffected by treatment with a minimally invasive strain. Taken together, these studies reveal that F. nucleatum may represent a challenging pathogen in the etiology of gut inflammatory diseases and highlight the importance of different pathotypes of candidate bacterial species in disease pathogenesis." @default.
- W2111282720 created "2016-06-24" @default.
- W2111282720 creator A5006098450 @default.
- W2111282720 creator A5029134053 @default.
- W2111282720 creator A5046210507 @default.
- W2111282720 creator A5078279956 @default.
- W2111282720 creator A5090644308 @default.
- W2111282720 date "2011-07-01" @default.
- W2111282720 modified "2023-10-11" @default.
- W2111282720 title "Fusobacterium nucleatum Infection of Colonic Cells Stimulates MUC2 Mucin and Tumor Necrosis Factor Alpha" @default.
- W2111282720 cites W1596657374 @default.
- W2111282720 cites W1926879430 @default.
- W2111282720 cites W1947786813 @default.
- W2111282720 cites W1966764926 @default.
- W2111282720 cites W1976870418 @default.
- W2111282720 cites W1981327571 @default.
- W2111282720 cites W1984341514 @default.
- W2111282720 cites W1986962193 @default.
- W2111282720 cites W2007948448 @default.
- W2111282720 cites W2026028158 @default.
- W2111282720 cites W2031228153 @default.
- W2111282720 cites W2032346799 @default.
- W2111282720 cites W2033811563 @default.
- W2111282720 cites W2039395305 @default.
- W2111282720 cites W2043620021 @default.
- W2111282720 cites W2049051908 @default.
- W2111282720 cites W2055592929 @default.
- W2111282720 cites W2065232553 @default.
- W2111282720 cites W2070861067 @default.
- W2111282720 cites W2075313774 @default.
- W2111282720 cites W2087556585 @default.
- W2111282720 cites W2089288381 @default.
- W2111282720 cites W2094402172 @default.
- W2111282720 cites W2107162587 @default.
- W2111282720 cites W2107277218 @default.
- W2111282720 cites W2117570635 @default.
- W2111282720 cites W2123957334 @default.
- W2111282720 cites W2127102828 @default.
- W2111282720 cites W2127860645 @default.
- W2111282720 cites W2128343971 @default.
- W2111282720 cites W2136419595 @default.
- W2111282720 cites W2138642538 @default.
- W2111282720 cites W2140678207 @default.
- W2111282720 cites W2155044429 @default.
- W2111282720 cites W2155286505 @default.
- W2111282720 cites W2162971726 @default.
- W2111282720 cites W2165528446 @default.
- W2111282720 cites W2166104982 @default.
- W2111282720 cites W2169351489 @default.
- W2111282720 cites W3141586554 @default.
- W2111282720 cites W4244626580 @default.
- W2111282720 cites W4245498610 @default.
- W2111282720 doi "https://doi.org/10.1128/iai.05118-11" @default.
- W2111282720 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3191979" @default.
- W2111282720 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21536792" @default.
- W2111282720 hasPublicationYear "2011" @default.
- W2111282720 type Work @default.
- W2111282720 sameAs 2111282720 @default.
- W2111282720 citedByCount "111" @default.
- W2111282720 countsByYear W21112827202012 @default.
- W2111282720 countsByYear W21112827202013 @default.
- W2111282720 countsByYear W21112827202014 @default.
- W2111282720 countsByYear W21112827202015 @default.
- W2111282720 countsByYear W21112827202016 @default.
- W2111282720 countsByYear W21112827202017 @default.
- W2111282720 countsByYear W21112827202018 @default.
- W2111282720 countsByYear W21112827202019 @default.
- W2111282720 countsByYear W21112827202020 @default.
- W2111282720 countsByYear W21112827202021 @default.
- W2111282720 countsByYear W21112827202022 @default.
- W2111282720 countsByYear W21112827202023 @default.
- W2111282720 crossrefType "journal-article" @default.
- W2111282720 hasAuthorship W2111282720A5006098450 @default.
- W2111282720 hasAuthorship W2111282720A5029134053 @default.
- W2111282720 hasAuthorship W2111282720A5046210507 @default.
- W2111282720 hasAuthorship W2111282720A5078279956 @default.
- W2111282720 hasAuthorship W2111282720A5090644308 @default.
- W2111282720 hasBestOaLocation W21112827202 @default.
- W2111282720 hasConcept C104317684 @default.
- W2111282720 hasConcept C142724271 @default.
- W2111282720 hasConcept C150194340 @default.
- W2111282720 hasConcept C179264091 @default.
- W2111282720 hasConcept C17991360 @default.
- W2111282720 hasConcept C203014093 @default.
- W2111282720 hasConcept C2776460866 @default.
- W2111282720 hasConcept C2777116383 @default.
- W2111282720 hasConcept C2777349128 @default.
- W2111282720 hasConcept C2778260677 @default.
- W2111282720 hasConcept C2779134260 @default.
- W2111282720 hasConcept C2780183776 @default.
- W2111282720 hasConcept C2780942790 @default.
- W2111282720 hasConcept C49039625 @default.
- W2111282720 hasConcept C523546767 @default.
- W2111282720 hasConcept C54355233 @default.
- W2111282720 hasConcept C55493867 @default.
- W2111282720 hasConcept C71924100 @default.
- W2111282720 hasConcept C86803240 @default.
- W2111282720 hasConcept C89423630 @default.