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- W2111291753 endingPage "1624" @default.
- W2111291753 startingPage "1613" @default.
- W2111291753 abstract "Mouse coat colour genes have long been studied as a paradigm for genetic interactions in development. A number of these genes have been cloned and most correspond to human genetic disease loci. The proteins encoded by these genes include transcription factors, receptor tyrosine kinases and growth factors, G-protein coupled receptors and their ligands, membrane proteins, structural proteins and enzymes. Many of the mutations have pleiotropic effects, indicating that these proteins play a wider role in developmental or cellular processes. In this review I tabulate the available data on all pigmentation genes cloned from mouse or human, and I focus on three particular systems. One family of genes, including LYST and HPS/ep, shows the relationship between melanosomes and lysosomes. The G-protein coupled receptor, endothelin receptor-B, and its ligand, endothelin-3, are required for the development of both melanocytes and enteric neurons. The melanocortin-1 receptor is expressed only on melanocytes, but mutations that cause overexpression of agouti protein, an antagonist of the receptor, result in obesity, and highlight a role of melanocortins in weight homoeostasis." @default.
- W2111291753 created "2016-06-24" @default.
- W2111291753 creator A5070906741 @default.
- W2111291753 date "1997-09-01" @default.
- W2111291753 modified "2023-10-14" @default.
- W2111291753 title "Homologous pigmentation mutations in human, mouse and other model organisms" @default.
- W2111291753 cites W110122724 @default.
- W2111291753 cites W14083555 @default.
- W2111291753 cites W1492379905 @default.
- W2111291753 cites W1494422541 @default.
- W2111291753 cites W1512958442 @default.
- W2111291753 cites W1577268287 @default.
- W2111291753 cites W1580209680 @default.
- W2111291753 cites W1588057732 @default.
- W2111291753 cites W1844798178 @default.
- W2111291753 cites W1951705554 @default.
- W2111291753 cites W1964701931 @default.
- W2111291753 cites W1965628553 @default.
- W2111291753 cites W1975606633 @default.
- W2111291753 cites W1976321898 @default.
- W2111291753 cites W1979420492 @default.
- W2111291753 cites W1980462022 @default.
- W2111291753 cites W1981605211 @default.
- W2111291753 cites W1981974890 @default.
- W2111291753 cites W1982527304 @default.
- W2111291753 cites W1984839756 @default.
- W2111291753 cites W1985475480 @default.
- W2111291753 cites W1986594478 @default.
- W2111291753 cites W1987264065 @default.
- W2111291753 cites W1989180038 @default.
- W2111291753 cites W1995363107 @default.
- W2111291753 cites W1999435075 @default.
- W2111291753 cites W2003999230 @default.
- W2111291753 cites W2005843398 @default.
- W2111291753 cites W2010142606 @default.
- W2111291753 cites W2013944173 @default.
- W2111291753 cites W2014626078 @default.
- W2111291753 cites W2017690914 @default.
- W2111291753 cites W2017784204 @default.
- W2111291753 cites W2018139276 @default.
- W2111291753 cites W2021912968 @default.
- W2111291753 cites W2022670725 @default.
- W2111291753 cites W2024058819 @default.
- W2111291753 cites W2027810940 @default.
- W2111291753 cites W2029009599 @default.
- W2111291753 cites W2031916690 @default.
- W2111291753 cites W2037588819 @default.
- W2111291753 cites W2037695813 @default.
- W2111291753 cites W2038619206 @default.
- W2111291753 cites W2038935117 @default.
- W2111291753 cites W2045593483 @default.
- W2111291753 cites W2046273758 @default.
- W2111291753 cites W2048554203 @default.
- W2111291753 cites W2049849193 @default.
- W2111291753 cites W2051372495 @default.
- W2111291753 cites W2051463940 @default.
- W2111291753 cites W2060035117 @default.
- W2111291753 cites W2060408705 @default.
- W2111291753 cites W2062423918 @default.
- W2111291753 cites W2062847609 @default.
- W2111291753 cites W2065389660 @default.
- W2111291753 cites W2074170762 @default.
- W2111291753 cites W2075990052 @default.
- W2111291753 cites W2077064092 @default.
- W2111291753 cites W2077388067 @default.
- W2111291753 cites W2077909568 @default.
- W2111291753 cites W2078772015 @default.
- W2111291753 cites W2078972442 @default.
- W2111291753 cites W2079266222 @default.
- W2111291753 cites W2083116048 @default.
- W2111291753 cites W2083715717 @default.
- W2111291753 cites W2085626543 @default.
- W2111291753 cites W2089951482 @default.
- W2111291753 cites W2090602010 @default.
- W2111291753 cites W2093642234 @default.
- W2111291753 cites W2097303099 @default.
- W2111291753 cites W2099410622 @default.
- W2111291753 cites W2104058217 @default.
- W2111291753 cites W2107482604 @default.
- W2111291753 cites W2107601465 @default.
- W2111291753 cites W2116306988 @default.
- W2111291753 cites W2119521084 @default.
- W2111291753 cites W2120500181 @default.
- W2111291753 cites W2122302939 @default.
- W2111291753 cites W2125040596 @default.
- W2111291753 cites W2127593794 @default.
- W2111291753 cites W2129884189 @default.
- W2111291753 cites W2131550182 @default.
- W2111291753 cites W2134254169 @default.
- W2111291753 cites W2137370771 @default.
- W2111291753 cites W2140577722 @default.
- W2111291753 cites W2143051878 @default.
- W2111291753 cites W2145297890 @default.
- W2111291753 cites W2148060680 @default.
- W2111291753 cites W2149405805 @default.
- W2111291753 cites W2153867200 @default.
- W2111291753 cites W2154336224 @default.
- W2111291753 cites W2155493652 @default.