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- W2111330221 endingPage "80" @default.
- W2111330221 startingPage "75" @default.
- W2111330221 abstract "The cyclic environmental conditions brought about by the 24 h rotation of the earth have allowed the evolution of endogenous circadian clocks that control the temporal alignment of behaviour and physiology, including the uptake and processing of nutrients. Both metabolic and circadian regulatory systems are built upon a complex feedback network connecting centres of the central nervous system and different peripheral tissues. Emerging evidence suggests that circadian clock function is closely linked to metabolic homeostasis and that rhythm disruption can contribute to the development of metabolic disease. At the same time, metabolic processes feed back into the circadian clock, affecting clock gene expression and timing of behaviour. In this review, we summarize the experimental evidence for this bimodal interaction, with a focus on the molecular mechanisms mediating this exchange, and outline the implications for clock-based and metabolic diseases." @default.
- W2111330221 created "2016-06-24" @default.
- W2111330221 creator A5039124761 @default.
- W2111330221 creator A5043280554 @default.
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- W2111330221 date "2009-08-01" @default.
- W2111330221 modified "2023-09-25" @default.
- W2111330221 title "A time to fast, a time to feast: The crosstalk between metabolism and the circadian clock" @default.
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- W2111330221 doi "https://doi.org/10.1007/s10059-009-0113-0" @default.
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