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• W2111331308 endingPage "1294" @default.
• W2111331308 startingPage "1287" @default.
• W2111331308 abstract "Previous studies suggest that carotid body responses to long-term changes in environmental oxygen differ between neonates and adults. In the present study we tested the hypothesis that the effects of chronic intermittent hypoxia (CIH) on the carotid body differ between neonates and adult rats. Experiments were performed on neonatal (1–10 days) and adult (6–8 wk) males exposed either to CIH (9 episodes/h; 8 h/day) or to normoxia. Sensory activity was recorded from ex vivo carotid bodies. CIH augmented the hypoxic sensory response (HSR) in both groups. The magnitude of CIH-evoked hypoxic sensitization was significantly greater in neonates than in adults. Seventy-two episodes of CIH were sufficient to evoke hypoxic sensitization in neonates, whereas as many as 720 CIH episodes were required in adults, suggesting that neonatal carotid bodies are more sensitive to CIH than adult carotid bodies. CIH-induced hypoxic sensitization was reversed in adult rats after reexposure to 10 days of normoxia, whereas the effects of neonatal CIH persisted into adult life (2 mo). Acute intermittent hypoxia (IH) evoked sensory long-term facilitation of the carotid body activity (sensory LTF, i.e., increased baseline neural activity following acute IH) in CIH-exposed adults but not in neonates. The effects of CIH were associated with hyperplasia of glomus cells in neonatal but not in adult carotid bodies. These observations demonstrate that responses to CIH differ between neonates and adults with regard to the magnitude of sensitization of HSR, susceptibility to CIH, induction of sensory LTF, reversibility of the responses, and morphological remodeling of the chemoreceptor tissue." @default.
• W2111331308 created "2016-06-24" @default.
• W2111331308 creator A5004128762 @default.
• W2111331308 creator A5064414704 @default.
• W2111331308 creator A5081208876 @default.
• W2111331308 creator A5091872663 @default.
• W2111331308 date "2008-05-01" @default.
• W2111331308 modified "2023-10-15" @default.
• W2111331308 title "Comparative analysis of neonatal and adult rat carotid body responses to chronic intermittent hypoxia" @default.
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• W2111331308 doi "https://doi.org/10.1152/japplphysiol.00644.2007" @default.
• W2111331308 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3893879" @default.
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